Reciprocal Interactions between Lactoferrin and Bacterial Endotoxins and Their Role in the Regulation of the Immune Response

Lactoferrin (Lf), an iron-binding glycoprotein expressed in most biological fluids, represents a major component of the mammalian innate immune system. Lf’s multiple activities rely not only on its capacity to bind iron, but also to interact with molecular and cellular components of both host and pathogens. Lf can bind and sequester lipopolysaccharide (LPS), thus preventing pro-inflammatory pathway activation, sepsis and tissue damage. However, Lf-bound LPS may retain the capacity to induce cell activation via Toll-like receptor 4-dependent and -independent mechanisms. This review discusses the complex interplay between Lf and LPS and its relevance in the regulation of the immune response

Correction to: Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation.

Narcolepsy is a rare chronic neurological disorder characterized by an irresistible excessive daytime sleepiness and cataplexy. The disease is considered to be the result of the selective disruption of neuronal cells in the lateral hypothalamus expressing the neuropeptide hypocretin, which controls the sleep-wake cycle. Diagnosis and management of narcolepsy represent still a substantial medical challenge due to the large heterogeneity in the clinical manifestation of the disease as well as to the lack of understanding of the underlying pathophysiological mechanisms. However, significant advances have been made in the last years, thus opening new perspective in the field. This review describes the current knowledge of clinical presentation and pathology of narcolepsy as well as the existing diagnostic criteria and therapeutic intervention for the disease management. Recent evidence on the potential immune-mediated mechanisms that may underpin the disease establishment and progression are also highlighted.ISSN:1863-2297ISSN:1863-230

Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation.

Narcolepsy is a rare chronic neurological disorder characterized by an irresistible excessive daytime sleepiness and cataplexy. The disease is considered to be the result of the selective disruption of neuronal cells in the lateral hypothalamus expressing the neuropeptide hypocretin, which controls the sleep-wake cycle. Diagnosis and management of narcolepsy represent still a substantial medical challenge due to the large heterogeneity in the clinical manifestation of the disease as well as to the lack of understanding of the underlying pathophysiological mechanisms. However, significant advances have been made in the last years, thus opening new perspective in the field. This review describes the current knowledge of clinical presentation and pathology of narcolepsy as well as the existing diagnostic criteria and therapeutic intervention for the disease management. Recent evidence on the potential immune-mediated mechanisms that may underpin the disease establishment and progression are also highlighted

Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation.

Narcolepsy is a rare chronic neurological disorder characterized by an irresistible excessive daytime sleepiness and cataplexy. The disease is considered to be the result of the selective disruption of neuronal cells in the lateral hypothalamus expressing the neuropeptide hypocretin, which controls the sleep-wake cycle. Diagnosis and management of narcolepsy represent still a substantial medical challenge due to the large heterogeneity in the clinical manifestation of the disease as well as to the lack of understanding of the underlying pathophysiological mechanisms. However, significant advances have been made in the last years, thus opening new perspective in the field. This review describes the current knowledge of clinical presentation and pathology of narcolepsy as well as the existing diagnostic criteria and therapeutic intervention for the disease management. Recent evidence on the potential immune-mediated mechanisms that may underpin the disease establishment and progression are also highlighted

Editorial: Knocking on neuroimmunology’s doors: an entrechat concerning the immune system balance and its cell metabolism orchestration

ISSN:1664-322

Soluble Variants of Human Recombinant Glutaminyl Cyclase

Soluble variants QPC

Diseño del sistema de gestión de Seguridad y Salud en el Trabajo para la empresa "Comercializadora Danser" de la ciudad de Pereira

El propósito de este trabajo ha sido diseñar un sistema de seguridad y salud en el trabajo para la empresa DISTRIBUIDORA DANSER que fue creada en el año 2016 por Sergio Manuel Nieto Parra, uno de los integrantes de esta tesis; ya que todas las empresas deben cumplir con este requisito..

El reconocimiento del daño moral en las personas jurídicas: un estudio normativo y jurisprudencial en Colombia sobre la aceptación de daño moral en las comunidades indígenas.

Desde la promulgación de la Constitución Política los derechos de las comunidades indígenas tomaron un rol más protagónico en el ámbito de las políticas públicas y en las decisiones judiciales. Por otra parte, el Consejo de Estado, viene modificando sus pronunciamientos judiciales frente al reconocimiento del daño moral en las personas jurídicas, admitiendo en algunos casos la posibilidad de ser reparado a pesar de que se esté frente personas ficticias que no pueden sentir afectaciones morales. Dicho esto, el presente trabajo tiene como objeto de estudio identificar la forma como se reconoce los morales en personas jurídicas respecto de las comunidades indígenas de acuerdo a la jurisprudencia en Colombia.Since the promulgation of the Political Constitution, the rights of indigenous communities took a more leading role in the field of public policies and in judicial decisions. On the other hand, the State Council has been modifying its judicial pronouncements against the recognition of moral damage in legal persons, admitting in some cases the possibility of being repaired despite the fact that it is facing fictitious persons who cannot feel moral damages. Having said that, this paper aims to study how morals are recognized in legal persons with respect to indigenous communities according to the jurisprudence in Colombia

Análisis de fracturas y caracterización de diaclasas de la formación Villeta, sector occidental de la subcuenca de Neiva

To evaluate naturally fractured reservoirs, there are different sources of information and methods that may be of limited access or high costs, especially for formations in which their level of productivity is unknown, or that have not yet been studied to determine their viability as hydrocarbon producer. Therefore, this article presents the application of an outcrop analysis method, as a source of indirect information, to characterize and determine the possible migration routes of the Hondita and Lomagorda carbonate formations belonging to the Villeta group. In the development of this characterization, the use of rectangular window-type fracture sampling strategies was implemented, through the exercise of taking structural measures, such as direction, dip, separation and spacing, over delimited areas in the outcrops of the formations of interest. With the help of the results, were identified 7 zones of joints, with a trend in low-angle courses with ranges in the northeast direction, establishing that this would be the predominance of fluid migration; giving an expectation that these data positively improve the development of the reservoirs.Para evaluar los yacimientos naturalmente fracturados se tienen diferentes fuentes de información y métodos que pueden ser de limitado acceso o de altos costos, especialmente para formaciones en las que se desconoce su nivel de productividad, o que aún no se ha estudiado para determinar su viabilidad como productora de hidrocarburos. Por lo que en este artículo se presenta la aplicación de un método de análisis de afloramiento, como fuente de información indirecta, para caracterizar y determinar las posibles vías de migración de las formaciones carbonatadas Hondita y Lomagorda pertenecientes al grupo Villeta. En el desarrollo de esta caracterización se implementó el uso de estrategias de muestreo de fracturas de tipo ventana rectangular, mediante el ejercicio de tomar medidas estructurales, como rumbo, buzamiento, separación y espaciamiento, sobre zonas delimitadas en los afloramientos de las formaciones de interés. Con ayuda de los resultados se identificaron 7 zonas de diaclasas, con una tendencia en rumbos de bajo ángulo con rangos en dirección noreste, estableciendo que esta sería la predominancia de migración de fluidos; dando una expectativa para que estos datos mejoren positivamente el desarrollo de los yacimientos