Primjene teorije grafova: topologijski modeli za predvi|anje CDK-1 inhibicijske aktivnosti aloizina

Relationship between the topological indices and cyclin-dependent kinase-1 (CDK-1/cyclin B) inhibitory activity of 6-phenyl[5H]pyrrolo[2,3-b]pyrazines (aloisines) was investigated. Three topological indices – the Wiener Index, a distance-based topological descriptor, the Zagreb group parameter, an adjacency based topological descriptor, and the eccentric connectivity index, an adjacency-cum-distance based topological descriptor were used in the study. A data set comprising 51 analogues of aloisine was selected for the present study. Values of the Wiener index, the Zagreb group parameter and the eccentric connectivity index for each of the 51 analogues included in the data set were computed using an in-house computer program. Resultant data was analyzed and suitable models were developed after identification of active ranges. A biological activity was then assigned to each compound using these models, which was then compared with the reported CDK-1 inhibitory activity. Accuracy of prediction using these models was found to vary from a minimum of ≈82 % to a maximum of 84 %. .Istraživan je odnos izmđ|u topologijskih indeksa i CDK-1 inhibicijske aktivnosti 5-fenil[5H]pirolo[2,3-b]- pirazina (aloizina). Upotrebljena su tri topologijska indeksa: Wienerov indeks, zagrebački indeks i ekscentrični indeks povezanosti, koji su izračunani za 51 aloizin. Dobiveni modeli predviđaju inhibijsku aktivnosti aloizina s točnošću od 82–84 %

Multi Area Load Frequency Control Using Particle Swarm Optimization and Fuzzy Rules

AbstractThis paper present heuristics based study of multi area power network. Heuristic procedures involving Particle Swarm Intelligence and Fuzzy based inferences have been employed to effectively obtain the optimized gains of PID controller. Any change in the load demand causes generator's shaft speed lower than the pre-set value and the system frequency deviates from the standard value results in malfunctioning of frequency relays. A five area load frequency model is constructed in Matlab/simulink by implementing the PID (Proportional, Integral and Differential) controllers to control the frequency deviations. The effect of interconnection of multi area power system as ring connection has been discussed. Simulations performed show the effectiveness of the current approach over simple fuzzy inferences in terms of performance as well as execution efficiency

What We Talk about When We Talk about Love: A Duoethnographic Exploration of the Dissertation Relationship

In the aftermath and mop-up following a successful dissertation defense, an unintended and unexpected data source remained unexplored and unanalyzed: 32 audio-recorded discussions and work sessions documenting the processes, approaches, and decisions made by a dissertation director and his doctoral candidate. What might those conversations reveal about the dissertation relationship? Taking a page from Raymond Carver’s short story, “What We Talk about When We Talk about Love,” we wondered what we might have been talking about when we were talking about dissertation writing. Inspired and shaped by Norris, Sawyer, and Lund’s (2012. Duoethnography: Dialogic methods for social, health, and educational research. Walnut Creek, CA: Left Coast Press.) duoethnographic methods, this study provides opportunity for us to not just look back on the journey, but pushes us into the messiness of “recalling and reconceptualizing” (p. 10). As we each “become the foil for the Other, challenging the Other to reflect on their own life in a deeper, more relational, and authentic manner” (Norris et al., 2012, p. 10) we also interrogate and trouble our own simplistic categories of analysis

When does the action start and finish? Making the case for an ethnographic action research in educational research

This paper explores how ethnographic and action research methodologies can be justifiably combined to create a new methodological approach in educational research. It draws on existing examples in both educational research and development studies that have discussed the use of ethnography and action research in specific projects. Interpretations of ethnography and action research are developed that aim to minimise the epistemological differences between them. The paper also contextualises an ‘ethnographic action research’ approach with reference to an example of the author’s research into participation in three ‘reception’ (first year of schooling) classes in the United Kingdom. It is argued that research into the theme of participation in early years education, using participative methods, was particularly suitable for this new methodological approach

The purpose of mess in action research: building rigour though a messy turn

Mess and rigour might appear to be strange bedfellows. This paper argues that the purpose of mess is to facilitate a turn towards new constructions of knowing that lead to transformation in practice (an action turn). Engaging in action research - research that can disturb both individual and communally held notions of knowledge for practice - will be messy. Investigations into the 'messy area', the interface between the known and the nearly known, between knowledge in use and tacit knowledge as yet to be useful, reveal the 'messy area' as a vital element for seeing, disrupting, analysing, learning, knowing and changing. It is the place where long-held views shaped by professional knowledge, practical judgement, experience and intuition are seen through other lenses. It is here that reframing takes place and new knowing, which has both theoretical and practical significance, arises: a 'messy turn' takes place

Embodied Discourses of Literacy in the Lives of Two Preservice Teachers

This study examines the emerging teacher literacy identities of Ian and A.J., two preservice teachers in a graduate teacher education program in the United States. Using a poststructural feminisms theoretical framework, the study illustrates the embodiment of literacy pedagogy discourses in relation to the literacy courses’ discourse of comprehensive literacy and the literacy biographical discourses of Ian and A.J. The results of this study indicate the need to deconstruct how the discourse of comprehensive literacy limits how we, as literacy teacher educators, position, hear and respond to our preservice teachers and suggests the need for differentiation in our teacher education literacy courses

Improving Patient Throughput in Akron General Cleveland Clinic Postpartum Unit

Exceeding hospital limitations can impair safety and induce unnecessary health risks for patients and staff. At Akron General Cleveland Clinic (AGCC), current birth rates are double the amount the facility is designed to handle. In order to accommodate increasing numbers, it must be seen that birthing mothers and their infants are not withholding space more than what is deemed required. Patients are permitted to stay 48 to 96 hours proceeding birth, given the type of delivery. However, many are unaware that they can be discharged between 24 and 48 hours post-delivery, so long as a physician has signed off on the matter. Techniques have been implemented to help improve patient throughput in postpartum units. These techniques have proven to significantly decrease both the number of length of stay (LOS) hours and recovery time versus preliminary studies

Brazen Charm: The Vitality of Homeric Armor

https://egrove.olemiss.edu/classics_lectures/1010/thumbnail.jp