Studies On The Lagoons Of East Centeral Florida

Detailed examination of the water quality parameters of the lagoons of East Central Florida were begun in 1969. This investigation was subsequently expanded to include other aspects of these waters. General trends and a statistical model are beginning to emerge for the water quality parameters. Man-made and natural effects have resulted in substantial alteration of water parameters since the study was initiated

An Ecological Study of the Lagoons Surrounding the John F. Kennedy Space Center, Brevard County, Florida

The studies reported here are the result of a three year effort to define the major biological, microbiological, chemical and geological characteristics of the water of the Indian River lagoon around the Kennedy Space Center and to determine the movements of those waters within and between the various basins. This work was the result of a jointly funded agreement between the Florida Institute of Technology and John F. Kennedy Space Center, NASA under NASA Grant NGR 10-015-008, dated April 11, 1972. This cost sharing grant was renewed for each of two successive years. Sampling operations were terminated August 31, 1975

An analysis of project high water data

Optical and radio frequency electromagnetic observations of high water release in ionosphere and atmospheric turbulence following liquid release in spac

An ecological study of the KSC Turning Basin and adjacent waters

The conditions existing in the waters and bottoms of the Turning Basin, the borrow pit near Pad 39A, and the Barge Canal connecting them were investigated to determine the ecological significance of the chemical, biological, and microbiological parameters. The water quality, biological, microbiological findings are discussed. It is recommended that future dredging activities be limited in depth, and that fill materials should not be removed down to the clay strata

Transitioning to Multiple-use Polyculture Grassland-derived Bioenergy Feedstock Systems

We argue that research and development of grassland-derived bioenergy feedstock (GBF) has focused unduly on dedicated monospecific biomass systems to the detriment of more stable multiple-use multispecies grasslands. This has retarded GBF adoption as a viable, sustainable contribution to renewable energy production in North America. We hypothesize that focusing on multiple-use GBFs will foster greater feedstock availability for nascent renewable energy generation while minimizing financial risk to grassland husbandry during market transitions from current grazing systems to more flexible business models. Our hypothesis is that source and demand are more likely to develop simultaneously under less risky multiple-use grassland management. We review what little research exists detailing such multiple-use systems that include GBF as a major component. We propose that more federal and private sector research funding should focus on perennial forage legumes and bunchgrasses for multiple uses including forage, bioenergy, grassland restoration, wildlife, and ecosystems services such as hydrology, carbon capture and biodiversity. These data cover both native and introduced species in cultivated pastures as well as managed rangeland and native grassland. We conclude that more research effort should be focused on multiple-use GBF in order to identify individual species, mixtures and ecosystems that provide flexibility in the face of unpredictable grassland environments and volatile energy markets

Snapshots of interprofessional education to enhance clinical team work and self-efficacy

Complex care needs of patients in health services means that multi-disciplinary treatments are required. To work productively as a team member in this environment requires education and training. Inter-professional Education (IPE) research shows that health practitioners who are educated and trained to work together promote patient safety (ACQSHC, 2005; Morrissey et al, 2010). However, the literature and observation from practice shows that training is either absent or ad hoc. Thus, practitioners are not adequately prepared for the differences world-views and in practices that may occur as a result of diverse discipline-based theories and skills. Tensions inevitably arise and the very basis for multidisciplinary teams – to embrace diverse views - is undermined because clinicians feel threatened and unhappy. Across the world there are many innovative educators who have embraced the challenge of developing IPE and from which we all can learn. This paper provides snapshots of practice from five countries. We discuss situations in need of improvement, educational interventions and evaluation data illustrating positive outcomes. Expected outcomes of the presentation are that educators are inspired to draw on and adapt these ideas so that inter-professional learning in health is integrated into curricula and utilised to improve patient safety and clinicians’ self-efficacy

The use of contextualised standardised client simulation to develop clinical reasoning in final year veterinary students

Clinical reasoning is an important skill for veterinary students to develop before graduation. Simulation has been studied in medical education as a method for developing clinical reasoning in students, but evidence supporting it is limited. This study involved the creation of a contextualized, standardized client simulation session that aimed to improve the clinical reasoning ability and confidence of final-year veterinary students. Sixty-eight participants completed three simulated primary-care consultations, with the client played by an actor and the pet by a healthy animal. Survey data showed that all participants felt that the session improved their clinical decision-making ability. Quantitative clinical reasoning self-assessment, performed using a validated rubric, triangulated this finding, showing an improvement in students’ perception of several components of their clinical reasoning skill level from before the simulation to after it. Blinded researcher analysis of the consultation video recordings found that students showed a significant increase in ability on the history-taking and making-sense-of-data (including formation of a differential diagnosis) components of the assessment rubric. Thirty students took part in focus groups investigating their experience with the simulation. Two themes arose from thematic analysis of these data: variety of reasoning methods and “It’s a different way of thinking.” The latter highlights differences between the decision making students practice during their time in education and the decision making they will use once they are in practice. Our findings suggest that simulation can be used to develop clinical reasoning in veterinary students, and they demonstrate the need for further research in this area

Case studies of interprofessional education initiatives from five countries

Background Although teamwork and interprofessional collaboration are critical to patient safety, healthcare graduates frequently report that they often feel ill-prepared to confidently communicate and collaborate with other team members. While interprofessional education has been advocated as a way of addressing this issue, there are multiple barriers to its systematic and sustained integration in undergraduate healthcare programs. Despite these challenges, examples of effective IPE initiatives have emerged. Purpose This paper profiles seven case studies of innovative interprofessional education activities that have been successfully implemented across five countries, for a variety of learners and using different delivery modalities. The evaluation results from these interprofessional education activities attest to their impact and positive outcomes. Conclusion These case studies demonstrate that the barriers to interprofessional education can be overcome when creative and targeted approaches are used. This paper provides a wealth of ideas for the successful design and implementation of interprofessional education initiatives and will be of benefit to educators wishing to expand their repertoire of teaching approaches. Clinical Relevance: A body of research attests to the relationship between interprofessional communication, teamwork and patient outcomes. Interprofessional education is imperative for facilitating the development of graduates’ communication and teamwork skills, however, innovative approaches are needed to overcome the perceived and actual impediments to its implementation

A Positive Feedback Synapse from Retinal Horizontal Cells to Cone Photoreceptors

Cone photoreceptors and horizontal cells (HCs) have a reciprocal synapse that underlies lateral inhibition and establishes the antagonistic center-surround organization of the visual system. Cones transmit to HCs through an excitatory synapse and HCs feed back to cones through an inhibitory synapse. Here we report that HCs also transmit to cone terminals a positive feedback signal that elevates intracellular Ca2+ and accelerates neurotransmitter release. Positive and negative feedback are both initiated by AMPA receptors on HCs, but positive feedback appears to be mediated by a change in HC Ca2+, whereas negative feedback is mediated by a change in HC membrane potential. Local uncaging of AMPA receptor agonists suggests that positive feedback is spatially constrained to active HC-cone synapses, whereas the negative feedback signal spreads through HCs to affect release from surrounding cones. By locally offsetting the effects of negative feedback, positive feedback may amplify photoreceptor synaptic release without sacrificing HC-mediated contrast enhancement

Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma

The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-κB, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. Fifteen genetically diverse models developed bone marrow (BM) tumors fulfilling MM pathogenesis. Integrative analyses of ∼500 mice and ∼1,000 patients revealed a common MAPK-MYC genetic pathway that accelerated time to progression from precursor states across genetically heterogeneous MM. MYC-dependent time to progression conditioned immune evasion mechanisms that remodeled the BM microenvironment differently. Rapid MYC-driven progressors exhibited a high number of activated/exhausted CD8+ T cells with reduced immunosuppressive regulatory T (Treg) cells, while late MYC acquisition in slow progressors was associated with lower CD8+ T cell infiltration and more abundant Treg cells. Single-cell transcriptomics and functional assays defined a high ratio of CD8+ T cells versus Treg cells as a predictor of response to immune checkpoint blockade (ICB). In clinical series, high CD8+ T/Treg cell ratios underlie early progression in untreated smoldering MM, and correlated with early relapse in newly diagnosed patients with MM under Len/Dex therapy. In ICB-refractory MM models, increasing CD8+ T cell cytotoxicity or depleting Treg cells reversed immunotherapy resistance and yielded prolonged MM control. Our experimental models enable the correlation of MM genetic and immunological traits with preclinical therapy responses, which may inform the next-generation immunotherapy trials