563 research outputs found
Semiempirical airframe noise prediction model and evaluation with flight data
A semiempirical maximum overall sound pressure level (OASPL) airframe noise model was derived. Noise radiated from aircraft wings was modeled on the trailing edge diffractes quadrupole sound theory. The acoustic dipole sound theory was used to model noise from the landing gear. The model was correlated with maximum OASPL flyover noise measurements obtained for three jet aircraft. One third octave band sound pressure level flyover data was correlated and interpreted
The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy
Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. Currently, there is no clear understanding of the mechanisms underlying the contribution of CAA to neurodegeneration. Despite the fact that CAA is highly associated with the accumulation of Aβ, other types of amyloids have been shown to associate with the vasculature. Interestingly, in many cases, vascular amyloidosis has been associated with an active immune response and perivascular deposition of hyperphosphorylated tau. Despite the fact that in Alzheimer’s disease (AD) a major focus of research has been the understanding of the connection between parenchymal amyloid plaques, tau aggregates in the form of neurofibrillary tangles (NFTs), and immune activation, the contribution of tau and neuroinflammation to neurodegeneration associated with CAA remains understudied. In this review, we discussed the existing evidence regarding the amyloid diversity in CAA and its relation to tau pathology and immune response, as well as the possible contribution of molecular and cellular mechanisms, previously associated with parenchymal amyloid in AD and AD-related dementias, to the pathogenesis of CAA. The detailed understanding of the “amyloid-tau-neuroinflammation” axis in the context of CAA could open the opportunity to develop therapeutic interventions for dementias associated with CAA that are currently being proposed for AD and AD-related dementias
Geophysical methods to support correct water sampling locations for salt dilution gauging
To improve water management design, particularly
in irrigation areas, it is important to evaluate the baseline
state of the water resources, including canal discharge.
Salt dilution gauging is a traditional and well-documented
technique in this respect. The complete mixing of salt used
for dilution gauging is required; this condition is difficult to
test or verify and, if not fulfilled, is the largest source of uncertainty
in the discharge calculation. In this paper, a geophysical
technique (FERT, fast electrical resistivity tomography)
is proposed for imaging the distribution of the salt
plume used for dilution gauging at every point along a sampling
cross section. With this imaging, complete mixing can
be verified. If the mixing is not complete, the image created
by FERT can also provide a possible guidance for selecting
water-sampling locations in the sampling cross section. A
water multi-sampling system prototype aimed to potentially
take into account concentration variability is also proposed
and tested.
The results reported in the paper show that FERT provides
a three-dimensional image of the dissolved salt plume and
that this can potentially help in the selection of water sampling
points
Hydrochemical and isotopic applications in the western aosta valley (Italy) for sustainable groundwater management
Groundwater resources in the main ethiopian rift valley: An overview for a sustainable development
In arid and semi-arid areas, human health and economic development depend on water availability, which can be greatly compromised by droughts. In some cases, the presence of natural contaminants may additionally reduce the availability of good quality water. This research analyzed the water resources and hydrochemical characteristics in a rural area of the central Main Ethiopian Rift Valley, particularly in the districts of Shashemene, Arsi Negelle, and Siraro. The study was developed using a census of the main water points (springs and wells) in the area and the sampling and physico-chemical analysis of the water, with particular regard to the fluoride concentration. In many cases, fluoride content exceeded the drinking water limits set by the World Health Organization, even in the absence of anthropogenic contamination. Two different aquifers were recognized: A shallow aquifer related to the eastern escarpment and highlands, and a deep aquifer in the lowland areas of the rift valley on the basis of compositional changes from Ca–Mg/HCO3 to Na–HCO3. The distribution of fluoride, as well as pH and EC values, showed a decrease from the center of the lowlands to the eastern highlands, with similar values closely aligned along an NNE/SSW trend. All these data contribute to creating awareness among and sharing information on the risks with rural communities and local governments to support the adequate use of the available water resources and to plan appropriate interventions to increase access to fresh water, aimed at the sustainable human and rural local development of the region
Temperature and discharge variations in natural mineral water springs due to climate variability: a case study in the Piedmont Alps (NW Italy)
Meteorological variability and groundwater quality: Examples in different hydrogeological settings
Rainfall and temperature variability causes changes in groundwater recharge that can also influence groundwater quality by different processes. The aim of this study is the analysis of the hydrogeochemical variations over time due to meteorological variability in two different study areas in Italy: an alluvial aquifer in the Piedmont Po plain and an alluvial-pyroclastic aquifer in the Campanian plain. The examined plains show groundwater with natural quality not satisfying the European drinking water standards, or anthropogenic contamination. The peculiar natural quality is due, in the Campanian plain, to the closeness of volcanic areas, and to the presence of reducing conditions. In Piedmont plain a test site is characterized by a point-source contamination by heavy metals, due to the presence of past industrial activities. In all the examined areas there is a diffuse nitrate contamination. The fluctuations of the ions As, F, Fe, Mn, Cr VI, NO3, and Cl were analyzed and compared, using statistical methods, with the variations over time in precipitation, temperature, and piezometric levels, sometimes significant. Results highlight the importance of the groundwater and meteorological monitoring and the key role of the recharge variation in the hydrogeochemical processes. The linking degree between rainfall/temperature variability and hydrogeochemistry is variable, in function of the typology of chemical species, their origin, and of the aquifer characteristics. The fluctuation of climate variables determines sudden changes in the geochemistry of shallow unconfined aquifers (e.g., in the Piedmont plain), while semiconfined or confined aquifers (e.g., in the Volturno-Regi Lagni plain) react with a greater delay to these variations. Moreover, natural quality is more affected by climatic variations than anthropogenic contamination, which is the result of multiple environmental and anthropic factors
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