32 research outputs found
Reconstruction of annular bi-layered media in cylindrical waveguide section
A radial transverse resonance model for two cylindrical concentric layers
with different complex dielectric constants is presented. An inverse problem
with four unknowns - 3 physical material parameters and one dimensional
dielectric layer thickness parameter- is solved by employing TE110 and TE210
modes with different radial field distribution. First a Newton-Raphson
algorithm is used to solve a least square problem with a Lorentzian function
(as resonance model and "measured" data generator). Then found resonance
frequencies and quality factors are used in a second inverse Newton-Raphson
algorithm that solves four transverse resonance equations in order to get four
unknown parameters. The use of TE110 and TE210 models offers one dimensional
radial tomographic capability. An open ended coax quarter-wave resonator is
added to the sensor topology, and the effect on the convergence is
investigated
Transverse Momentum Spectra in Au+Au and d+Au Collisions at =200 GeV and the Pseudorapidity Dependence of High p Suppression
We present spectra of charged hadrons from Au+Au and d+Au collisions at
GeV measured with the BRAHMS experiment at RHIC. The
spectra for different collision centralities are compared to spectra from collisions at the same energy scaled by the number of binary
collisions. The resulting ratios (nuclear modification factors) for central
Au+Au collisions at and evidence a strong suppression in
the high region (2 GeV/c). In contrast, the d+Au nuclear
modification factor (at ) exhibits an enhancement of the high
yields. These measurements indicate a high energy loss of the high
particles in the medium created in the central Au+Au collisions. The lack of
suppression in d+Au collisions makes it unlikely that initial state effects can
explain the suppression in the central Au+Au collisions.Comment: 4 pages, 4 figures, submitted to Phys. Rev. Let
Rapidity Dependence of Charged Antiparticle-to-Particle Ratios in Au+Au Collisions at GeV
We present ratios of the numbers of charged antiparticles to particles
(pions, kaons and protons) in Au + Au collisions at GeV as
a function of rapidity in the range =0-3. While the particle ratios at
midrapidity are approaching unity, the and ratios
decrease significantly at forward rapidities. An interpretation of the results
within the statistical model indicates a reduction of the baryon chemical
potential from MeV at =3 to MeV at
=0.Comment: 4 pages, 4 figure
The Physical Activity and Fitness in Childhood Cancer Survivors (PACCS) Study: Protocol for an International Mixed Methods Study
BACKGROUND
Survivors of childhood cancer represent a growing population with a long life expectancy but high risks of treatment-induced morbidity and premature mortality. Regular physical activity (PA) may improve their long-term health; however, high-quality empirical knowledge is sparse.
OBJECTIVE
The Physical Activity and Fitness in Childhood Cancer Survivors (PACCS) study comprises 4 work packages (WPs) aiming for the objective determination of PA and self-reported health behavior, fatigue, and quality of life (WP 1); physical fitness determination (WP 2); the evaluation of barriers to and facilitators of PA (WP 1 and 3); and the feasibility testing of an intervention to increase PA and physical fitness (WP 4).
METHODS
The PACCS study will use a mixed methods design, combining patient-reported outcome measures and objective clinical and physiological assessments with qualitative data gathering methods. A total of 500 survivors of childhood cancer aged 9 to 18 years with ≥1 year after treatment completion will be recruited in follow-up care clinics in Norway, Denmark, Finland, Germany, and Switzerland. All participants will participate in WP 1, of which approximately 150, 40, and 30 will be recruited to WP 2, WP3, and WP 4, respectively. The reference material for WP 1 is available from existing studies, whereas WP 2 will recruit healthy controls. PA levels will be measured using ActiGraph accelerometers and self-reports. Validated questionnaires will be used to assess health behaviors, fatigue, and quality of life. Physical fitness will be measured by a cardiopulmonary exercise test, isometric muscle strength tests, and muscle power and endurance tests. Limiting factors will be identified via neurological, pulmonary, and cardiac evaluations and the assessment of body composition and muscle size. Semistructured, qualitative interviews, analyzed using systematic text condensation, will identify the perceived barriers to and facilitators of PA for survivors of childhood cancer. In WP 4, we will evaluate the feasibility of a 6-month personalized PA intervention with the involvement of local structures.
RESULTS
Ethical approvals have been secured at all participating sites (Norwegian Regional Committee for Medical Research Ethics [2016/953 and 2018/739]; the Oslo University Hospital Data Protection Officer; equivalent institutions in Finland, Denmark [file H-19032270], Germany, and Switzerland [Ethics Committee of Northwestern and Central Switzerland, project ID: 2019-00410]). Data collection for WP 1 to 3 is complete. This will be completed by July 2022 for WP 4. Several publications are already in preparation, and 2 have been published.
CONCLUSIONS
The PACCS study will generate high-quality knowledge that will contribute to the development of an evidence-based PA intervention for young survivors of childhood cancer to improve their long-term care and health. We will identify physiological, psychological, and social barriers to PA that can be targeted in interventions with immediate benefits for young survivors of childhood cancer in need of rehabilitation.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)
DERR1-10.2196/35838
Quark Gluon Plasma an Color Glass Condensate at RHIC? The perspective from the BRAHMS experiment
We review the main results obtained by the BRAHMS collaboration on the
properties of hot and dense hadronic and partonic matter produced in
ultrarelativistic heavy ion collisions at RHIC. A particular focus of this
paper is to discuss to what extent the results collected so far by BRAHMS, and
by the other three experiments at RHIC, can be taken as evidence for the
formation of a state of deconfined partonic matter, the so called
quark-gluon-plasma (QGP). We also discuss evidence for a possible precursor
state to the QGP, i.e. the proposed Color Glass Condensate.Comment: 32 pages, 18 figure
Nuclear modification factors at forward rapidity in Au-Au and Cu-Cu collisions at root s(NN)=62.4 GeV
The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations
The mechanisms contributing to multiorgan dysfunction during cardiogenic shock are poorly understood. Our goal was to characterize the microcirculatory and mitochondrial responses following ≥ 10 hours of severe left ventricular failure and cardiogenic shock. We employed a closed-chest porcine model of cardiogenic shock induced by left coronary microembolization (n = 12) and a time-matched control group (n = 6). Hemodynamics and metabolism were measured hourly by intravascular pressure catheters, thermodilution, arterial and organ specific blood gases. Echocardiography and assessment of the sublingual microcirculation by sidestream darkfield imaging were performed at baseline, 2 ± 1 and 13 ± 3 (mean ± SD) hours after coronary microembolization. Upon hemodynamic decompensation, cardiac, renal and hepatic mitochondria were isolated and evaluated by high-resolution respirometry. Low cardiac output, hypotension, oliguria and severe reductions in mixed-venous and hepatic O2 saturations were evident in cardiogenic shock. The sublingual total and perfused vessel densities were fully preserved throughout the experiments. Cardiac mitochondrial respiration was unaltered, whereas state 2, 3 and 4 respiration of renal and hepatic mitochondria were increased in cardiogenic shock. Mitochondrial viability (RCR; state 3/state 4) and efficiency (ADP/O ratio) were unaffected. Our study demonstrates that the microcirculation is preserved in a porcine model of untreated cardiogenic shock despite vital organ hypoperfusion. Renal and hepatic mitochondrial respiration is upregulated, possibly through demand-related adaptations, and the endogenous shock response is thus compensatory and protective, even after several hours of global hypoperfusion