G93-1182 Best Management Practices for Agricultural Pesticides to Protect Water Resources

This NebGuide discusses what happens to pesticides after application, factors affecting pesticide movement, and best management practices to minimize the potential for pesticide contamination of ground and surface water. Users of pesticides and other agricultural chemicals must take appropriate precautions to reduce the risks of moving these materials into ground or surface water. The primary consideration should be whether the chemical is needed. If pesticides are needed, then the characteristics of the chemical, the sensitivity of the application site and the method of application should be considered

Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo

Arrays of electrodes for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, yet are unable to sample large areas of the brain while maintaining high spatial resolution because of the need to individually wire each passive sensor at the electrode-tissue interface. To overcome this constraint, we have developed new devices integrating ultrathin and flexible silicon nanomembrane transistors into the electrode array, enabling new dense arrays of thousands of amplified and multiplexed sensors connected using many fewer wires. We used this system to record novel spatial properties of brain activity in vivo, including sleep spindles, single-trial visual evoked responses, and electrographic seizures. Our electrode array allowed us to discover that seizures may manifest as recurrent spiral waves which propagate in the neocortex. The developments reported here herald a new generation of diagnostic and therapeutic brain-machine interface (BMI) devices