Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Standing Up and Speaking Out Against Prejudice Toward Gay Men in the Workplace

In this research, we examine prejudice based on sexual orientation in the workplace and strategies employees can use to confront it. First, in a qualitative investigation designed to examine some of the major assumptions of this research, lesbian, gay, and bisexual (LGB) employees and heterosexual “allies” highlighted the importance of confronting prejudice and reported hesitation in knowing how to do so effectively. Second, we then experimentally tested various previously-identified confrontation styles to (a) determine the implications of confronting (compared to not confronting) for the confronter and the perpetrator from a third-party perspective and (b) examine which style may be optimal. The results of this study suggest how observers of prejudice might intervene to (a) reduce the amount of backlash confronters receive, (b) maximize the perceived culpability of the perpetrator, and (c) elicit future confrontation behaviors among other observers: by engaging in calm confrontations that directly implicate the perpetrator of prejudice as being at fault

Gray Wolf Restoration in the Northwestern United States

Gray wolf (Canis lupus) populations were eliminated from Montana, Idaho, and Wyoming, as well as adjacent southwestern Canada by the 1930s. After human-caused mortality of wolves in southwestern Canada began to be regulated in the 1960s, populations began expanding southward. Dispersing individuals occasionally reached the northern Rocky Mountains of the United States, but lacked legal protection there until 1974, after passage of the Endangered Species Act of 1973. In 1986, wolves from Canada successfully raised a litter of pups in Glacier National Park, Montana, and a small population was soon established. In 1995 and 1996, wolves from western Canada were reintroduced to remote public lands in central Idaho and Yellowstone National Park. These wolves were designated as nonessential experimental populations to increase management flexibility and address local and state concerns. Wolf restoration is rapidly occurring in Montana, Idaho, and Wyoming, and there were at least 28 breeding pairs in December 2000. There are now about 63 adult wolves in northwestern Montana, 192 in central Idaho, and 177 in the Greater Yellowstone area. Dispersal of wolves between Canada, Montana, Idaho, and Wyoming has been documented. Occasional lone wolves may disperse into adjacent states, but population establishment outside of Montana, Idaho, and Wyoming is probably not imminent. The gray wolf population in the northwestern U.S. should be recovered and, depending on the completion of state and tribal wolf conservation plans, could be proposed to be removed from Act protection within three years. Wolf restoration has proceeded more quickly and with more benefits, such as public viewing than predicted. Problems, including confirmed livestock depredations, have been lower than estimated. The Service led interagency recovery program focuses its efforts on achieving wolf recovery while addressing the concerns of people who live near wolves. Wolves have restored an important ecological process to several large wild areas in the northern Rocky Mountains of the U.S. The program has been widely publicized and is generally viewed as highly successful

Restructuring

This report is available in alternative forms upon reques

The Nairobi Declaration—Reducing the burden of dementia in low‐ and middle‐income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs

[No abstract available