329 research outputs found
THE IMPACT OF EMPLOYMENT EXPANSION ON RURAL COMMUNITY SERVICE EXPENDITURES: A SMALL AREA MODEL
Labor and Human Capital, Public Economics,
Psychic costs and factor price equalization
There has been some perplexity among economists over the failure of interregional wage differentials to approach zero over time in an economy characterized by labor mobility. Johnson [7], and Sjaastad [14] , among others, have hypothesized declining wage differentials among regions and have puzzled over contrary empirical results. It has generally been assumed that labor will flow toward regions paying the highest wage rate. This equilibrating framework has dominated economic thought on this problem area and has directed research along narrow market-oriented lines. The hypothesis of this paper is that nonmarket considerations, specifically psychic costs, are a major force in preventing a market-directed flow of human resources. Moreover, "nonoptimal" allocation of human resources results from differences in workers' perceptions of utility between various regions. We will first review the literature in this area and then present an empirical analysis of demographic characteristics suggesting the magnitude of the psychic factor
Conserved syntenic clusters of protein coding genes are missing in birds
BACKGROUND: Birds are one of the most highly successful and diverse groups of vertebrates, having evolved a number of distinct characteristics, including feathers and wings, a sturdy lightweight skeleton and unique respiratory and urinary/excretion systems. However, the genetic basis of these traits is poorly understood. RESULTS: Using comparative genomics based on extensive searches of 60 avian genomes, we have found that birds lack approximately 274 protein coding genes that are present in the genomes of most vertebrate lineages and are for the most part organized in conserved syntenic clusters in non-avian sauropsids and in humans. These genes are located in regions associated with chromosomal rearrangements, and are largely present in crocodiles, suggesting that their loss occurred subsequent to the split of dinosaurs/birds from crocodilians. Many of these genes are associated with lethality in rodents, human genetic disorders, or biological functions targeting various tissues. Functional enrichment analysis combined with orthogroup analysis and paralog searches revealed enrichments that were shared by non-avian species, present only in birds, or shared between all species. CONCLUSIONS: Together these results provide a clearer definition of the genetic background of extant birds, extend the findings of previous studies on missing avian genes, and provide clues about molecular events that shaped avian evolution. They also have implications for fields that largely benefit from avian studies, including development, immune system, oncogenesis, and brain function and cognition. With regards to the missing genes, birds can be considered ‘natural knockouts’ that may become invaluable model organisms for several human diseases. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-014-0565-1) contains supplementary material, which is available to authorized users
Observational Constraints on the Catastrophic Disruption Rate of Small Main Belt Asteroids
We have calculated 90% confidence limits on the steady-state rate of
catastrophic disruptions of main belt asteroids in terms of the absolute
magnitude at which one catastrophic disruption occurs per year (HCL) as a
function of the post-disruption increase in brightness (delta m) and subsequent
brightness decay rate (tau). The confidence limits were calculated using the
brightest unknown main belt asteroid (V = 18.5) detected with the Pan-STARRS1
(Pan-STARRS1) telescope. We measured the Pan-STARRS1's catastrophic disruption
detection efficiency over a 453-day interval using the Pan-STARRS moving object
processing system (MOPS) and a simple model for the catastrophic disruption
event's photometric behavior in a small aperture centered on the catastrophic
disruption event. Our simplistic catastrophic disruption model suggests that
delta m = 20 mag and 0.01 mag d-1 < tau < 0.1 mag d-1 which would imply that H0
= 28 -- strongly inconsistent with H0,B2005 = 23.26 +/- 0.02 predicted by
Bottke et al. (2005) using purely collisional models. We postulate that the
solution to the discrepancy is that > 99% of main belt catastrophic disruptions
in the size range to which this study was sensitive (100 m) are not
impact-generated, but are instead due to fainter rotational breakups, of which
the recent discoveries of disrupted asteroids P/2013 P5 and P/2013 R3 are
probable examples. We estimate that current and upcoming asteroid surveys may
discover up to 10 catastrophic disruptions/year brighter than V = 18.5.Comment: 61 Pages, 10 Figures, 3 Table
Main-Belt Comet P/2012 T1 (PANSTARRS)
We present initial results from observations and numerical analyses aimed at
characterizing main-belt comet P/2012 T1 (PANSTARRS). Optical monitoring
observations were made between October 2012 and February 2013 using the
University of Hawaii 2.2 m telescope, the Keck I telescope, the Baade and Clay
Magellan telescopes, Faulkes Telescope South, the Perkins Telescope at Lowell
Observatory, and the Southern Astrophysical Research (SOAR) telescope. The
object's intrinsic brightness approximately doubles from the time of its
discovery in early October until mid-November and then decreases by ~60%
between late December and early February, similar to photometric behavior
exhibited by several other main-belt comets and unlike that exhibited by
disrupted asteroid (596) Scheila. We also used Keck to conduct spectroscopic
searches for CN emission as well as absorption at 0.7 microns that could
indicate the presence of hydrated minerals, finding an upper limit CN
production rate of QCN<1.5x10^23 mol/s, from which we infer a water production
rate of QH2O<5x10^25 mol/s, and no evidence of the presence of hydrated
minerals. Numerical simulations indicate that P/2012 T1 is largely dynamically
stable for >100 Myr and is unlikely to be a recently implanted interloper from
the outer solar system, while a search for potential asteroid family
associations reveal that it is dynamically linked to the ~155 Myr-old Lixiaohua
asteroid family.Comment: 15 pages, 4 figures, accepted for publication in ApJ Letter
Prediction of preterm birth with and without preeclampsia using mid-pregnancy immune and growth-related molecular factors and maternal characteristics.
OBJECTIVE:To evaluate if mid-pregnancy immune and growth-related molecular factors predict preterm birth (PTB) with and without (±) preeclampsia. STUDY DESIGN:Included were 400 women with singleton deliveries in California in 2009-2010 (200 PTB and 200 term) divided into training and testing samples at a 2:1 ratio. Sixty-three markers were tested in 15-20 serum samples using multiplex technology. Linear discriminate analysis was used to create a discriminate function. Model performance was assessed using area under the receiver operating characteristic curve (AUC). RESULTS:Twenty-five serum biomarkers along with maternal age <34 years and poverty status identified >80% of women with PTB ± preeclampsia with best performance in women with preterm preeclampsia (AUC = 0.889, 95% confidence interval (0.822-0.959) training; 0.883 (0.804-0.963) testing). CONCLUSION:Together with maternal age and poverty status, mid-pregnancy immune and growth factors reliably identified most women who went on to have a PTB ± preeclampsia
Identification of known and novel long non-coding RNAs potentially responsible for the effects of BMD GWAS loci
Osteoporosis, characterized by low bone mineral density (BMD), is the most common complex disease affecting bone and constitutes a major societal health problem. Genome-wide association studies (GWASs) have identified over 1100 associations influencing BMD. It has been shown that perturbations to long non-coding RNAs (lncRNAs) influence BMD and the activities of bone cells; however, the extent to which lncRNAs are involved in the genetic regulation of BMD is unknown. Here, we combined the analysis of allelic imbalance (AI) in human acetabular bone fragments with a transcriptome-wide association study (TWAS) and expression quantitative trait loci (eQTL) colocalization analysis using data from the Genotype-Tissue Expression (GTEx) project to identify lncRNAs potentially responsible for GWAS associations. We identified 27 lncRNAs in bone that are located in proximity to a BMD GWAS association and harbor SNPs demonstrating AI. Using GTEx data we identified an additional 31 lncRNAs whose expression was associated (FDR correction0.1). The 58 lncRNAs are located in 43 BMD associations. To further support a causal role for the identified lncRNAs, we show that 23 of the 58 lncRNAs are differentially expressed as a function of osteoblast differentiation. Our approach identifies lncRNAs that are potentially responsible for BMD GWAS associations and suggest that lncRNAs play a role in the genetics of osteoporosis.First author draf
The Pan-STARRS Moving Object Processing System
We describe the Pan-STARRS Moving Object Processing System (MOPS), a modern
software package that produces automatic asteroid discoveries and
identifications from catalogs of transient detections from next-generation
astronomical survey telescopes. MOPS achieves > 99.5% efficiency in producing
orbits from a synthetic but realistic population of asteroids whose
measurements were simulated for a Pan-STARRS4-class telescope. Additionally,
using a non-physical grid population, we demonstrate that MOPS can detect
populations of currently unknown objects such as interstellar asteroids.
MOPS has been adapted successfully to the prototype Pan-STARRS1 telescope
despite differences in expected false detection rates, fill-factor loss and
relatively sparse observing cadence compared to a hypothetical Pan-STARRS4
telescope and survey. MOPS remains >99.5% efficient at detecting objects on a
single night but drops to 80% efficiency at producing orbits for objects
detected on multiple nights. This loss is primarily due to configurable MOPS
processing limits that are not yet tuned for the Pan-STARRS1 mission.
The core MOPS software package is the product of more than 15 person-years of
software development and incorporates countless additional years of effort in
third-party software to perform lower-level functions such as spatial searching
or orbit determination. We describe the high-level design of MOPS and essential
subcomponents, the suitability of MOPS for other survey programs, and suggest a
road map for future MOPS development.Comment: 57 Pages, 26 Figures, 13 Table
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