Effects of stimulus size and luminance on oscillopsia in congenital nystagmus

AbstractAlthough the absence of oscillopsia is a common feature of congenital nystagmus (CN), it is occasionally noted by patients under poor viewing conditions and has been provoked in laboratory settings with stabilised images. In the present study, the effects of reductions in background stimulus size and luminance on perceptual stability in CN were examined. Sixteen CN subjects were first interviewed using a structured questionnaire about whether they ever experienced oscillopsia and, if so, under what circumstances and with what perceptions. They next fixated an LED centred in projected images of three sizes (21×14°, 10×6° and 7×4°) and four luminance levels (115.5, 24.5, 2.7 and 0.1 cd/m2, with contrasts from 96 down to 20%). Eye movements were recorded with a limbal tracker. They were asked after viewing each image “whether anything happened to the image while they watched it.”Occasional oscillopsia was reported by 12/16 of the CN subjects on the questionnaire. In the laboratory, 13/16 subjects experienced oscillopsia in some manner for at least one of the stimuli. 8/13 CN subjects experienced it for the dimmest and smallest slides. 11/13 perceived certain parts (either the LED or background) of the visual stimuli as moving, with the perception of LED movement most pronounced at low background luminance. Foveation did not differ when trials with and without reported oscillopsia were compared (independent samples t-test, p>0.05).Oscillopsia may occur in CN with normal viewing of bright fixation targets against dim backgrounds. Under these conditions, the oscillopsia may be spatially inhomogeneous. Luminance differences between the fixation point and surround may have caused transmission time differences as the image moved across the retina, therefore leading to the perception of motion in one portion of the scene and not the other

Longitudinal assessment of reflexive and volitional saccades in Niemann-Pick Type C disease during treatment with miglustat

Peer reviewedPublisher PD

Optokinetic Nystagmus Suppression as an Index of the Allocation of Visual Attention

PURPOSE. To use the suppression of optokinetic nystagmus (OKN) as an objective measure of subjects' ability to distribute their visual attention to different elements-static or dynamic, simple or complex-in their visual environment. METHODS. Large-field, constant-velocity projected images, along with a stationary central fixation target were presented to 25 young participants (13 women). Images were either black O's with a few X's or red C's, blue T's, and a few red T's, with the X's and red T's as the search targets. Stationary targets at either 0°or Ϯ12.5°were either blinking squares or a rapid succession of colored shapes-blinks or green stars were the target events. Central fixation was maintained at all times. OKN gain was calculated for all tasks and analyzed in a mixed 4-way ANOVA, with the sex of the subjects as the group variable and dynamism, location, and complexity as within-subject effects. RESULTS. There was no effect of sex; all three main withinsubject effects were significant, as were the two-way interactions between them and an interaction between dynamism and sex. The most striking result was that there was little difference across static tasks but that dynamic tasks showed significantly more OKN breakthrough, particularly for the complex search presented centrally. CONCLUSIONS. In this group of normal-sighted young subjects, OKN breakthrough was sensitive to a range of stimulus characteristics. This finding allows a single outcome measure to be used across a wide range of possible tasks and may be useful in assessing the effects of age and disease. (Invest Ophthalmol Vis Sci. 2011;52:462-467

Saccadic Eye Movement Characteristics in Adult Niemann-Pick Type C Disease: Relationships with Disease Severity and Brain Structural Measures

Niemann-Pick Type C disease (NPC) is a rare genetic disorder of lipid metabolism. A parameter related to horizontal saccadic peak velocity was one of the primary outcome measures in the clinical trial assessing miglustat as a treatment for NPC. Neuropathology is widespread in NPC, however, and could be expected to affect other saccadic parameters. We compared horizontal saccadic velocity, latency, gain, antisaccade error percentage and self-paced saccade generation in 9 adult NPC patients to data from 10 age-matched controls. These saccadic measures were correlated with appropriate MRI-derived brain structural measures (e.g., dorsolateral prefrontal cortex, frontal eye fields, supplemental eye fields, parietal eye fields, pons, midbrain and cerebellar vermis) and with measures of disease severity and duration. The best discriminators between groups were reflexive saccade gain and the two volitional saccade measures. Gain was also the strongest correlate with disease severity and duration. Most of the saccadic measures showed strongly significant correlations with neurophysiologically appropriate brain regions. While our patient sample is small, the apparent specificity of these relationships suggests that as new diagnostic methods and treatments become available for NPC, a broader range of saccadic measures may be useful tools for the assessment of disease progression and treatment efficacy.No external funding was received for this study. JCLL self-funded computational, travel and accommodation costs to conduct his component of this research in Melbourne

A cross‐sectional, prospective ocular motor study in 72 patients with Niemann‐Pick disease type C

Objective: To characterize ocular motor function in patients with Niemann-Pick disease type C (NPC). Methods: In a multicontinental, cross-sectional study we characterized ocular-motor function in 72 patients from 12 countries by video-oculography. Interlinking with disease severity, we also searched for ocular motor biomarkers. Our study protocol comprised reflexive and self-paced saccades, smooth pursuit, and gaze-holding in horizontal and vertical planes. Data were compared with those of 158 healthy controls (HC). Results: Some 98.2% of patients generated vertical saccades below the 95% CI of the controls' peak velocity. Only 46.9% of patients had smooth pursuit gain lower than that of 95% CI of HC. The involvement in both downward and upward directions was similar (51°/s (68.9, [32.7-69.3]) downward versus 78.8°/s (65.9, [60.8-96.8]) upward). Horizontal saccadic peak velocity and latency, vertical saccadic duration and amplitude, and horizontal position smooth pursuit correlated best to disease severity. Compensating strategies such as blinks to elicit saccades, and head and upper body movements to overcome the gaze palsy, were observed. Vertical reflexive saccades were more impaired and slower than self-paced ones. Gaze-holding was normal. Ocular-motor performance depended on the age of onset and disease duration. Conclusions: This is the largest cohort of NPC patients investigated for ocular-motor function. Vertical supranuclear saccade palsy is the hallmark of NPC. Vertical upward and downward saccades are equally impaired. Horizontal saccadic peak velocity and latency, vertical saccadic duration and amplitude, and horizontal position smooth pursuit can be used as surrogate parameters for clinical trials. Compensating strategies can contribute to establishing a diagnosis

A meta-analysis of the investment-uncertainty relationship

In this article we use meta-analysis to investigate the investment-uncertainty relationship. We focus on the direction and statistical significance of empirical estimates. Specifically, we estimate an ordered probit model and transform the estimated coefficients into marginal effects to reflect the changes in the probability of finding a significantly negative estimate, an insignificant estimate, or a significantly positive estimate. Exploratory data analysis shows that there is little empirical evidence for a positive relationship. The regression results suggest that the source of uncertainty, the level of data aggregation, the underlying model specification, and differences between short- and long-run effects are important sources of variation in study outcomes. These findings are, by and large, robust to the introduction of a trend variable to capture publication trends in the literature. The probability of finding a significantly negative relationship is higher in more recently published studies. JEL Classification: D21, D80, E22 1

Attention Enhances the Retrieval and Stability of Visuospatial and Olfactory Representations in the Dorsal Hippocampus

Attention enhances the encoding and retrieval of olfactory and visuospatial representations by modulating place field stability, firing rate, and neuronal synchronization of pyramidal cells in the hippocampus