CBLAST 2003 field work report

The long-range scientific objective of the Coupled Boundary Layer Air Sea Transfer (CBLAST) project is to observe and understand the temporal and spatial variability of the upper ocean, to identify the processes that determine that variability, and to examine its predictability. Air-sea interaction is of particular interest, but attention is also paid to the coupling of the sub-thermocline ocean to the mixed layer and to both the open ocean and littoral regimes. We seek to do this over a wide range of environmental conditions with the intent of improving our understanding of upper ocean dynamics and of the physical processes that determine the vertical and horizontal structure of the upper ocean. Field work for CBLAST was conducted during the summers of 2001, 2002, and 2003 off the south shore of Martha’s Vineyard, Massachusetts. The 2003 field work was conducted from the following platforms: heavy moorings, light moorings, drifters, F/V Nobska, CIRPAS Pelican aircraft, and an IR Cessna Aircraft. This report documents the 2003 field work and includes field notes, platform descriptions, discussion of data returns, and mooring logs. The 2003 Intensive Operating Period (IOP) was very successful and a high data return was seen.Funding was provided by the Office of Naval Research under contract numbers N00014-01-1-0029 and N00014-05-10090

Are you handling genital oedema confidently?

Men, women or children can suffer from oedema (swelling) of the genitalia. When differential diagnosis has excluded acute trauma or pathology and swelling remains, the condition may be diagnosed as genital lymphoedema, a chronic condition that increases the relative risk of cellulitis. Diagnosis of genital oedema is often delayed due to problems with patient and health professional behaviour, in terms of embarrassment, lack of confidence or lack of knowledge. Awareness of this condition and knowledge on how to manage it will go a long way in helping both patients and clinicians overcome the challenges of addressing genital oedema. This article describes the authors' experiences in managing genital oedema. It also briefly discusses a new international project that seeks to identify the knowledge and training that health professionals need to manage this condition more confidently

Mannose binding lectin is required for alphavirus-induced arthritis/myositis

Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis. The pathology of RRV-induced disease in both humans and mice is associated with induction of the host inflammatory response within the muscle and joints, and prior studies have demonstrated that the host complement system contributes to development of disease. In this study, we have used a mouse model of RRV-induced disease to identify and characterize which complement activation pathways mediate disease progression after infection, and we have identified the mannose binding lectin (MBL) pathway, but not the classical or alternative complement activation pathways, as essential for development of RRV-induced disease. MBL deposition was enhanced in RRV infected muscle tissue from wild type mice and RRV infected MBL deficient mice exhibited reduced disease, tissue damage, and complement deposition compared to wild-type mice. In contrast, mice deficient for key components of the classical or alternative complement activation pathways still developed severe RRV-induced disease. Further characterization of MBL deficient mice demonstrated that similar to C3(-/-) mice, viral replication and inflammatory cell recruitment were equivalent to wild type animals, suggesting that RRV-mediated induction of complement dependent immune pathology is largely MBL dependent. Consistent with these findings, human patients diagnosed with RRV disease had elevated serum MBL levels compared to healthy controls, and MBL levels in the serum and synovial fluid correlated with severity of disease. These findings demonstrate a role for MBL in promoting RRV-induced disease in both mice and humans and suggest that the MBL pathway of complement activation may be an effective target for therapeutic intervention for humans suffering from RRV-induced arthritis and myositis.This work was supported by NIH/NIAMS R01 AR 047190 awarded to MTH

Additions to the marine decapod (Crustacea: Decapoda) fauna of South Africa

This report adds five previously unreported species to the decapod crustacean fauna of South Africa, as well as removing one species previously listed in error. It also documents locality (and/or reference specimen) data for 12 other species, most of which had been depicted in regional field guides, but without reporting when and where they had been collected. Almost all the species added were already known from adjacent African countries and their ranges are here extended into South Africa. Although some of these records are based on photographs, rather than collected specimens, it is argued that such records should be accepted as adequate evidence for inclusion of at least visually-distinctive crustacean species into the regional fauna

Study protocol for improving asthma outcomes through cross-cultural communication training for physicians: a randomized trial of physician training

Abstract Background Massive resources are expended every year on cross-cultural communication training for physicians. Such training is a focus of continuing medical education nationwide and is part of the curriculum of virtually every medical school in America. There is a pressing need for evidence regarding the effects on patients of cross-cultural communication training for physicians. There is a need to understand the added benefit of such training compared to more general communication. We know of no rigorous study that has assessed whether cross-cultural communication training for physicians results in better health outcomes for their patients. The current study aims to answer this question by enhancing the Physician Asthma Care Education (PACE) program to cross cultural communication (PACE Plus), and comparing the effect of the enhanced program to PACE on the health outcomes of African American and Latino/Hispanic children with asthma. Methods/Design A three-arm randomized control trial is used to compare PACE Plus, PACE, and usual care. Both PACE and PACE Plus are delivered in two, two-hour sessions over a period of two weeks to 5–10 primary care physicians who treat African American and Latino/Hispanic children with asthma. One hundred twelve physicians and 1060 of their pediatric patients were recruited who self-identify as African American or Latino/Hispanic and experience persistent asthma. Physicians were randomized into receiving either the PACE Plus or PACE intervention or into the control group. The comparative effectiveness of PACE and PACE Plus on clinician’s therapeutic and communication practices with the family/patient, children’s urgent care use for asthma, asthma control, and quality of life, and parent/caretaker satisfaction with physician performance will be assessed. Data are collected via telephone survey and medical record review at baseline, 9 months following the intervention, and 21 months following the intervention. Discussion This study aims to reduce disparities in asthma outcomes among African American and Latino/Hispanic children through cross-cultural communication training of their physicians and assessing the added value of this training compared to general communication. The results of this study will provide important information about the value of cross-cultural training in helping to address persistent racial disparities in outcomes. Trial registration ClinicalTrials.gov: NCT01251523 December 1, 2010http://deepblue.lib.umich.edu/bitstream/2027.42/109533/1/12909_2014_Article_948.pd

Mid-Infrared Observations of Class I/Flat-Spectrum Systems in Six Nearby Molecular Clouds

We have obtained new mid-infrared observations of 65 Class I/Flat-Spectrum (F.S.) objects in the Perseus, Taurus, Chamaeleon I/II, Rho Ophiuchi, and Serpens dark clouds. We detected 45/48 (94%) of the single sources, 16/16 (100%) of the primary components, and 12/16 (75%) of the secondary/triple components of the binary/multiple objects surveyed. The composite spectral energy distributions (SEDs) for all of our sample sources are either Class I or F.S., and, in 15/16 multiple systems, at least one of the individual components displays a Class I or F.S. spectral index. However, the occurrence of mixed pairings, such as F.S. with Class I, F.S. with Class II, and, in one case, F.S. with Class III, is surprisingly frequent. Such behaviour is not consistent with that of multiple systems among T Tauri stars (TTS), where the companion of a classical TTS also tends to be a classical TTS, although other mixed pairings have been previously observed among Class II objects. Based on an analysis of the spectral indices of the individual binary components, there appears to be a higher proportion of mixed Class I/F.S. systems (65-80%) than that of mixed Classical/Weak-Lined TTS (25-40%), demonstrating that the envelopes of Class I/ F.S. systems are rapidly evolving during this evolutionary phase. We report the discovery of a steep spectral index secondary companion to ISO-ChaI 97, detected for the first time via our mid-infrared observations. In our previous near- infrared imaging survey of binary/multiple Class I/F.S. sources, ISO-ChaI 97 appeared to be single. With a spectral index of Alpha >= 3.9, the secondary component of this system is a member of a rare class of very steep spectral index objects, those with Alpha > 3. Only three such objects have previously been reported, all of which are either Class 0 or Class I.Comment: 31 pages, 4 figures, 6 table

Galaxy And Mass Assembly (GAMA): a deeper view of the mass, metallicity and SFR relationships

A full appreciation of the role played by gas metallicity (Z), star formation rate (SFR) and stellar mass (M*) is fundamental to understanding how galaxies form and evolve. The connections between these three parameters at different redshifts significantly affect galaxy evolution, and thus provide important constraints for galaxy evolution models. Using data from the Sloan Digital Sky Survey–Data Release 7 (SDSS–DR7) and the Galaxy and Mass Assembly (GAMA) surveys, we study the relationships and dependences between SFR, Z and M*, as well as the Fundamental Plane for star-forming galaxies. We combine both surveys using volume-limited samples up to a redshift of z ≈ 0.36. The GAMA and SDSS surveys complement each other when analysing the relationships between SFR, M* and Z. We present evidence for SFR and metallicity evolution to z ∼ 0.2. We study the dependences between SFR, M*, Z and specific SFR (SSFR) on the M*–Z, M*–SFR, M*–SSFR, Z–SFR and Z–SSFR relations, finding strong correlations between all. Based on those dependences, we propose a simple model that allows us to explain the different behaviour observed between low- and high-mass galaxies. Finally, our analysis allows us to confirm the existence of a Fundamental Plane, for which M* = f(Z, SFR) in star-forming galaxies

Quantitative analysis of high-resolution, contrast-enhanced, cone-beam CT for the detection of intracranial in-stent hyperplasia

BACKGROUND: Intracranial in-stent hyperplasia is a stroke-associated complication that requires routine surveillance. OBJECTIVE: To compare the results of in vivo experiments to determine the accuracy and precision of in-stent hyperplasia measurements obtained with modified C-arm contrast-enhanced, cone-beam CT (CE-CBCT) imaging with those obtained by \u27gold standard\u27 histomorphometry. Additionally, to carry out clinical analyses comparing this CE-CBCT protocol with digital subtraction angiography (DSA). METHODS: A non-binned CE-CBCT protocol (VasoCT) was used that acquires x-ray images with a small field-of-view and applies a full-scale reconstruction algorithm providing high-resolution three-dimensional (3D) imaging with 100 microm isotropic voxels. In an vivo porcine model, VasoCT cross-sectional area measurements were compared with gold standard vessel histology. VasoCT and DSA were used to calculate in-stent stenosis in 23 imaging studies. RESULTS: Porcine VasoCT cross-sectional stent, lumen, and in-stent hyperplasia areas strongly correlated with histological measurements (r(2)=0.97, 0.93, 0.90; slope=1.14, 1.07, and 0.76, respectively; p\u3c0.0001). Clinical VasoCT percentage stenosis correlated well with DSA percentage stenosis (r(2)=0.84; slope=0.76), and the two techniques were free of consistent bias (Bland-Altman, bias=3.29%; 95% CI -14.75% to 21.33%). An illustrative clinical case demonstrated the advantages of VasoCT, including 3D capability and non-invasive IV contrast administration, for detection of in-stent hyperplasia. CONCLUSIONS: C-arm VasoCT is a high-resolution 3D capable imaging technique that has been validated in an animal model for measurement of in-stent tissue growth. Successful clinical implementation of the protocol was performed in a small case series. already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

The Integrity of ACSR Full Tension Single-Stage Splice Connector at Higher Operation Temperature

Due to increases in power demand and limited investment in new infrastructure, existing overhead power transmission lines often need to operate at temperatures higher than those used for the original design criteria. This has led to the accelerated aging and degradation of splice connectors. It is manifested by the formation of hot-spots that have been revealed by infrared imaging during inspection. The implications of connector aging is two-fold: (1) significant increases in resistivity of the splice connector (i.e., less efficient transmission of electricity) and (2) significant reductions in the connector clamping strength, which could ultimately result in separation of the power transmission line at the joint. Therefore, the splice connector appears to be the weakest link in electric power transmission lines. This report presents a protocol for integrating analytical and experimental approaches to evaluate the integrity of full tension single-stage splice connector assemblies and the associated effective lifetime at high operating temperature