A Monte Carlo study of the three-dimensional Coulomb frustrated Ising ferromagnet

We have investigated by Monte-Carlo simulation the phase diagram of a three-dimensional Ising model with nearest-neighbor ferromagnetic interactions and small, but long-range (Coulombic) antiferromagnetic interactions. We have developed an efficient cluster algorithm and used different lattice sizes and geometries, which allows us to obtain the main characteristics of the temperature-frustration phase diagram. Our finite-size scaling analysis confirms that the melting of the lamellar phases into the paramgnetic phase is driven first-order by the fluctuations. Transitions between ordered phases with different modulation patterns is observed in some regions of the diagram, in agreement with a recent mean-field analysis.Comment: 14 pages, 10 figures, submitted to Phys. Rev.

Energy Sector Market Analysis

This paper presents the results of energy market analysis sponsored by the Department of Energy's (DOE) Weatherization and International Program (WIP) within the Office of Energy Efficiency and Renewable Energy (EERE). The analysis was conducted by a team of DOE laboratory experts from the National Renewable Energy Laboratory (NREL), Oak Ridge National Laboratory (ORNL), and Pacific Northwest National Laboratory (PNNL), with additional input from Lawrence Berkeley National Laboratory (LBNL). The analysis was structured to identify those markets and niches where government can create the biggest impact by informing management decisions in the private and public sectors. The analysis identifies those markets and niches where opportunities exist for increasing energy efficiency and renewable energy use

Can prolonged sitting impair cerebral blood flow and autoregulation?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90617/1/AIAA-2011-857-617.pd

Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors

AbstractIn this study, we report a series of newly synthesised sulphonamides of aziridine-2-carboxylic acid (Az-COOH) ester and amide analogues as potent protein disulphide isomerase (PDI, EC 5.3.4.1) inhibitors. The inhibitory activity on PDI was determined against recombinant human PDIA1 and PDIA3 proteins using an insulin reduction assay. These compounds in low micromolar to low nanomolar concentrations showed the effective in vitro inhibitory properties of PDIA1 with weaker effects on PDIA3. Complexes of 15N- and 15N,13C- uniformly labelled recombinant human PDIA1a with two PDIA1 inhibitors were produced and investigated by a protein nuclear magnetic resonance (NMR) spectroscopy. It was found that both C53 and C56 of the PDIA1 enzyme were involved in covalent binding. Finally, in a range of pharmacological studies, we demonstrated that investigated compounds displayed anti-cancer and anti-thrombotic activity. These findings demonstrate that sulphonamides of Az-COOH derivatives are promising candidates for the development of novel anti-cancer and anti-thrombotic agents

Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors

In this study, we report a series of newly synthesised sulphonamides of aziridine-2-carboxylic acid (Az-COOH) ester and amide analogues as potent protein disulphide isomerase (PDI, EC 5.3.4.1) inhibitors. The inhibitory activity on PDI was determined against recombinant human PDIA1 and PDIA3 proteins using an insulin reduction assay. These compounds in low micromolar to low nanomolar concentrations showed the effective in vitro inhibitory properties of PDIA1 with weaker effects on PDIA3. Complexes of 15N- and 15N,13C- uniformly labelled recombinant human PDIA1a with two PDIA1 inhibitors were produced and investigated by a protein nuclear magnetic resonance (NMR) spectroscopy. It was found that both C53 and C56 of the PDIA1 enzyme were involved in covalent binding. Finally, in a range of pharmacological studies, we demonstrated that investigated compounds displayed anti-cancer and anti-thrombotic activity. These findings demonstrate that sulphonamides of Az-COOH derivatives are promising candidates for the development of novel anti-cancer and anti-thrombotic agents.</p

Performance Analysis of a Prototype High‐Concentration Photovoltaic System Coupled to Silica Optical Fibers

International audienc

Accidentally in the Public Interest: The Perfect Storm that Yielded the Sarbanes-Oxley Act

In the face of varied protests over the mandates of the U.S. Sarbanes-Oxley Act, pressure has mounted to ease the impact of Sarbanes on non-U.S. companies and smaller companies. The rhetoric around these protests tend to be based on essentially three issues: (1) the imperialistic nature of the U.S. legislation, (2) the abnormal fashion in which the Act worked its way through the U.S. legislative process, and (3) the balance between costs and benefits of the requirements mandated in Sarbanes. This study focuses on working through the rhetoric in order to understand the intent of Sarbanes, the perfect storm that developed and carried the bill through the legislative process, and the debate over costs versus benefits. The position that is arrived at in the paper is that a simultaneous combination of intense scrutiny by the press, the unveiling of another major financial scandal (i.e. WorldCom), and a Senate committee that placed heavy reliance on former SEC Chairman Levitt\u27s corporate governance proposals created a storm that the business and accounting lobbies could not counter, and the result was a significant piece of legislation that almost by accident created one of the greatest protections in history for the public interest within the arena of the financial markets and related corporate behavior. The benefits appear to be worth the costs. © 2007 Elsevier Ltd. All rights reserved