Multiple-path technique for the determination of physico-chemical data behind shock fronts

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Technologies and Practices to Reduce Impacts of Artificial Light at Night on Nightime Scenery

Artificial light at night (ALAN) adversely impacts nighttime scenery values. Current standards for LED lighting have led to brighter nighttime lighting, using color temperatures that are more harmful to human and ecological health, and which create an exponentially larger landscape impact than historical ALAN technologies. Less-harmful LED lighting and other existing technologies can be used to control artificial light at night, creating safe and pleasing perceptual nighttime experiences while minimizing ecological impacts. Minimizing the impact of artificial light at night requires understanding new lighting technologies, and management practices that extend beyond current lighting standards. This is crucial in order to sustain and protect the visual and cultural qualities of the landscape, and the ecological functions that we enjoy and depend upon. This paper will outline how the human body perceives and is affected by light, a key component to the success of implementing light pollution mitigation; discuss existing and evolving fixture programming technologies, and present challenges faced and lessons learned in implementing new lighting standards that support visual resource stewardship

Impacts of Climate Change on the Power Industry and How It is Adapting

The Electrical Power and Energy Industry (the Power Industry) is facing great challenges with the transition to renewable energy options and sustainability (the Green Revolution) and the growing incidence of intelligent grid technology developments to encourage Customer-side responses (Smart Grid). At the same time, there is the definite need to meet continued demand growth (albeit slower) on top of the need for refurbishment and replacement of ageing assets and human resources (the looming Skills Gap) while coping with Climate Change and maintaining reliable and price competitive energy services in a safe and healthy environment and economy

Performance modeling of ultraviolet Raman lidar systems for daytime profiling of atmospheric water vapor

We describe preliminary results from a comprehensive computer model developed to guide optimization of a Raman lidar system for measuring daytime profiles of atmospheric water vapor, emphasizing an ultraviolet, solar-blind approach

PathRTM: Real-time prediction of KI-67 and tumor-infiltrated lymphocytes

In this paper, we introduce PathRTM, a novel deep neural network detector based on RTMDet, for automated KI-67 proliferation and tumor-infiltrated lymphocyte estimation. KI-67 proliferation and tumor-infiltrated lymphocyte estimation play a crucial role in cancer diagnosis and treatment. PathRTM is an extension of the PathoNet work, which uses single pixel keypoints for within each cell. We demonstrate that PathRTM, with higher-level supervision in the form of bounding box labels generated automatically from the keypoints using NuClick, can significantly improve KI-67 proliferation and tumorinfiltrated lymphocyte estimation. Experiments on our custom dataset show that PathRTM achieves state-of-the-art performance in KI-67 immunopositive, immunonegative, and lymphocyte detection, with an average precision (AP) of 41.3%. Our results suggest that PathRTM is a promising approach for accurate KI-67 proliferation and tumor-infiltrated lymphocyte estimation, offering annotation efficiency, accurate predictive capabilities, and improved runtime. The method also enables estimation of cell sizes of interest, which was previously unavailable, through the bounding box predictions.Comment: 12 pages, 11 figure

Study of resonance light scattering for remote optical probing

Enhanced scattering and fluorescence processes in the visible and UV were investigated which will enable improved remote measurements of gas properties. The theoretical relationship between scattering and fluorescence from an isolated molecule in the approach to resonance is examined through analysis of the time dependence of re-emitted light following excitation of pulsed incident light. Quantitative estimates are developed for the relative and absolute intensities of fluorescence and resonance scattering. New results are obtained for depolarization of scattering excited by light at wavelengths within a dissociative continuum. The experimental work was performed in two separate facilities. One of these utilizes argon and krypton lasers, single moded by a tilted etalon, and a 3/4 meter double monochromator. This facility was used to determine properties of the re-emission from NO2, I2 and O3 excited by visible light. The second facility involves a narrow-line dye laser, and a 3/4 meter single monochromator. The dye laser produces pulsed light with 5 nsec pulse duration and 0.005 nm spectral width

A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody.

The CCR5 receptor plays a role in several key physiological and pathological processes and is an important therapeutic target. Inhibition of the CCR5 axis by passive or active immunisation offers one very selective strategy for intervention. In this study we define a new linear epitope within the extracellular domain of CCR5 recognised by two independently produced monoclonal antibodies. A short peptide encoding the linear epitope can induce antibodies which recognise the intact receptor when administered colinear with a tetanus toxoid helper T cell epitope. The monoclonal antibody RoAb 13 is shown to bind to both cells and peptide with moderate to high affinity (6x10^8 and 1.2x107 M-1 respectively), and binding to the peptide is enhanced by sulfation of tyrosines at positions 10 and 14. RoAb13, which has previously been shown to block HIV infection, also blocks migration of monocytes in response to CCR5 binding chemokines and to inflammatory macrophage conditioned medium. A Fab fragment of RoAb13 has been crystallised and a structure of the antibody is reported to 2.1 angstrom resolution

Reading Retreats: Faculty Efforts to Revive Their Reading Program

In the United States, education and particular Reading education has undergone serious scrutiny over the past twenty years. From the Nation at Risk (1983) publication to the No Child Left Behind Act (2001), reading educators, who work directly with pre-service teachers, have had to confront several important challenges including establishing high academic standards for all students, developing and enhancing teachers’ knowledge of the latest and most effective educational practices and initiating systematic reform within the school system so that new curriculum frameworks are aligned to key state educational policy.The following paper describes how faculty in a reading program at a large metropolitan university along the southeastern coast of the United States reflected on current practice and discovered a means of maintaining their professional integrity while at the same time using professional development opportunities to create a reading program which is current, dynamic and effectively able to prepare future teachers who thrive in an environment of change.