9 research outputs found
Intimate Partner Violence Prevention Project with the Raleigh/Cary Chinese Community
IPV is a serious social and public health problem which causes physical injuries and psychological harm to the victims. In the United States, IPV was first identified as a national problem four decades ago by feminist movement (Kilpatrick, 2004), and has since gained increasing interest in its intervention and prevention. However, studies on IPV in Asian American population or its ethnic subgroups have been scarce. The purpose of our program is to obtain qualitative, culture-related IPV data from the Chinese immigrants who reside in the Raleigh/Cary metropolitan area in North Carolina. Not only will this information provide us a preliminary description of the nature of IPV in this community, more importantly, it could guide us to form hypotheses and develop programs which will increase the awareness and promote the prevention of IPV among this population.Master of Public Healt
A competing risk analysis of sequential complication development in Asian type 2 diabetes mellitus patients
This retrospective cohort study investigated the progression risk of sequential complication in Asian type 2 diabetes (T2D) patients using the Taiwan Pay-for-Performance Diabetes Registry and claim data from November 2003 to February 2009. 226,310 adult T2D patients without complication were followed from diagnosis to complications, including myocardial infarction (MI), other ischemic heart disease (IHD), congestive heart failure (CHF), stroke, chronic kidney disease (CKD), retinopathy, amputation, death or to the end of study. Cumulative incidences (CIs) of first and second complications were analyzed in 30 and 4 years using the cumulative incidence competing risk method. IHD (29.8%), CKD (24.5%) and stroke (16.0%) are the most common first complications. The further development of T2D complications depends on a patientās existing complication profiles. Patients who initially developed cardiovascular complications had a higher risk (9.2% to 24.4%) of developing IHD or CKD, respectively. All-cause mortality was the most likely consequence for patients with a prior MI (12.0%), so as stroke in patients with a prior MI (10.8%) or IHD (8.9%). Patients with CKD had higher risk of developing IHD (16.3%), stroke (8.9%) and all-cause mortality (8.7%) than end-stage renal disease (4.0%). Following an amputation, patients had a considerable risk of all-cause mortality (42.1%)
Signal-on Protein Detection via Dye Translocation between Aptamer and Quantum Dot
A unique
interaction between the cyanine dye and negatively charged quantum
dot is used to construct a signal-on biaptameric quantum dot (QD)
FoĢrster resonance energy transfer (FRET) beacon for protein
detection and distinct aptamer characterization. The beacon comprises
a pair of aptamers, one intercalated with the cyanine dye (YOYO-3)
and the other conjugated to a negatively charged, carboxyl-QD. When
the target protein is present, structural folding and sandwich association
of the two aptamers take place. As a consequence, YOYO-3 is displaced
from the folded aptamer and transferred to the unblocked QD surface
to yield a target concentration-dependent FRET signal. As a proof-of-principle,
we demonstrate the detection of thrombin ranging from nanomolar to
submicromolar concentrations and confirm the dye translocation using
cylindrical illumination confocal spectroscopy (CICS). The proposed
beacon provides a simple, rapid, signal-on FRET detection for protein
as well as a potential platform for distinct aptamer screening
ALMA Survey of Orion Planck Galactic Cold Clumps (ALMASOP): A Forming Quadruple System with Continuum āRibbonsā and Intricate Outflows
One of the most poorly understood aspects of low-mass star formation is how multiple-star systems are formed. Here we present the results of Atacama Large Millimeter/submillimeter Array (ALMA) Band 6 observations toward a forming quadruple protostellar system, G206.93-16.61E2, in the Orion B molecular cloud. ALMA 1.3 mm continuum emission reveals four compact objects, of which two are Class I young stellar objects and the other two are likely in prestellar phase. The 1.3 mm continuum emission also shows three asymmetric ribbon-like structures that are connected to the four objects, with lengths ranging from ā¼500 to ā¼2200 au. By comparing our data with magnetohydrodynamic simulations, we suggest that these ribbons trace accretion flows and also function as gas bridges connecting the member protostars. Additionally, ALMA CO J = 2ā1 line emission reveals a complicated molecular outflow associated with G206.93-16.61E2, with arc-like structures suggestive of an outflow cavity viewed pole-on