Optical Coherence Tomography Findings in Rhegmatogenous Retinal Detachment: A Systematic Review

Rhegmatogenous retinal detachment is a sight-threatening condition that may lead to blindness if left untreated. Surgical treatments may vary and are tailored to a single patient. Anatomical and functional results may vary, due to factors that are currently under study. Optical coherence tomography (OCT) allows a detailed visualization of the retinal structure. Some studies have been performed using OCT on eyes with retinal detachment. We performed a review on the subject. Several data have been obtained using different OCT applications. Some alterations may represent potential biomarkers since they are associated with visual and anatomical prognoses. Increased knowledge on the subject may be helpful to choose among different surgical strategies and endotamponades. More research on the topic is needed

The Ultraviolet Luminosity Density of the Universe from Photometric Redshifts of Galaxies in the Hubble Deep Field

Studies of the Hubble Deep Field (HDF) and other deep surveys have revealed an apparent peak in the ultraviolet (UV) luminosity density, and therefore the star-formation rate density, of the Universe at redshifts 1<z<2. We use photometric redshifts of galaxies in the HDF to determine the comoving UV luminosity density and find that, when errors (in particular, sampling error) are properly accounted for, a flat distribution is statistically indistinguishable from a distribution peaked at z~1.5. Furthermore, we examine the effects of cosmological surface brightness (SB) dimming on these measurements by applying a uniform SB cut to all galaxy fluxes after correcting them to redshift z=5. We find that, comparing all galaxies at the same intrinsic surface brightness sensitivity, the UV luminosity density contributed by high intrinsic SB regions increases by almost two orders of magnitude from z~0 to z~5. This suggests that there exists a population of objects with very high star formation rates at high redshifts that apparently do not exist at low redshifts. The peak of star formation, then, may occur somewhere beyond a redshift z~>5.Comment: 4 pages total, including 3 embedded figures, to appear in the proceedings of the Xth Rencontres de Blois, "The Birth of Galaxies." LaTeX style file include

The Origin of C IV Absorption Systems at Redshifts z<1---Discovery of Extended C IV Envelopes Around Galaxies

(Abridged) We report the discovery of extended CIV gaseous envelopes around galaxies of a wide range of luminosity and morphological type. First, we show that CIV absorption systems are strongly clustered around galaxies on velocity scales of v < 250 km/s and impact parameter scales of rho < 100 h^{-1} kpc but not on larger velocity or impact parameter scales. Next, adopting measurements of galaxy properties presented in previous papers, we examine how properties of the CIV absorption systems depend on properties of the galaxies. On the basis of 14 galaxy and absorber pairs and 36 galaxies that do not produce corresponding CIV absorption lines to within sensitive upper limits, we find that: (1) Galaxies of a range of morphological type and luminosity appear to possess extended CIV gaseous envelopes of radius R ~ 100 h^{-1} kpc, with abrupt boundaries between the CIV absorbing and non-absorbing regions. (2) The extent of CIV-absorbing gas around galaxies scales with galaxy B-band luminosity as R \propto L_B^{0.5 +/- 0.1} but does not depend strongly on galaxy surface brightness, redshift, or morphological type. And (3) the covering factor of CIV clouds within ~ 100 h^{-1} kpc of galaxies is nearly unity, but there is a large scatter in the mean number of clouds encountered along the line of sight. The most significant implication of the study is that galaxies of a wide range of luminosity and morphological type are surrounded by chemically enriched gas that extends for at least ~ 100 h^{-1} kpc. We consider various scenarios that may have produced metals at large galactic distance and conclude that accreting satellites are most likely to be responsible for chemically enriched gas at large galactic distances to regular looking galaxies.Comment: 19 pages, 3 figures, to appear in ApJ, July 20 200

Star-forming galaxies at very high redshifts

Analysis of the deepest available images of the sky, obtained by the Hubble Space Telescope, reveals a large number of candidate high-redshift galaxies. A catalogue of 1,683 objects is presented, with estimated redshifts ranging from $z=0$ to $z>6$. The high-redshift objects are interpreted as regions of star formation associated with the progenitors of present-day normal galaxies at epochs reaching to 95\% of the time to the Big Bang.Comment: 10 pages, LaTeX type, aaspp4.sty macro provided. Supplementary information, including the full catalog, plots of spectra and redshift likelihood functions for all the objects, and composite spectra, are available at ftp://ftp.ess.sunysb.edu/pub/hd

Detailed analysis of an endoreversible fuel cell : Maximum power and optimal operating temperature determination

Producing useful electrical work in consuming chemical energy, the fuel cell have to reject heat to its surrounding. However, as it occurs for any other type of engine, this thermal energy cannot be exchanged in an isothermal way in finite time through finite areas. As it was already done for various types of systems, we study the fuel cell within the finite time thermodynamics framework and define an endoreversible fuel cell. Considering different types of heat transfer laws, we obtain an optimal value of the operating temperature, corresponding to a maximum produced power. This analysis is a first step of a thermodynamical approach of design of thermal management devices, taking into account performances of the whole system.Comment: 15 pages, 10 figure

Managing diabetic macular edema in clinical practice: systematic review and meta-analysis of current strategies and treatment options

Purpose: This meta-analysis aims to summarize 12-month best-corrected visual acuity (BCVA) outcomes in response to anti-vascular endothelial growth factor (VEGF) therapy and dexamethasone implant for the treatment of diabetic macular edema (DME) and to identify factors affecting treatment response using evidence generated from metaregression. Methods: A systematic review of electronic databases was conducted to identify randomized controlled trials (RCTs) and real-life/observational studies that reported 12-month changes in BCVA in patients with DME on anti-VEGF or dexamethasone implant treatment in monotherapy. Study factors that were analyzed are baseline patient characteristics, study type, drug employed, number of injections and 12-month change in BCVA. Data were pooled in a random-effects meta-analysis with BCVA change as the main outcome. Meta-regression was conducted to assess the impact of multiple covariates. Results: One-hundred-five heterogeneous study populations (45,032 eyes) were identified and included in the analysis. The use of anti-VEGFs and dexamethasone implant induced an overall increase of +8.13 ETDRS letters in BCVA at 12 months of follow-up. Metaregression provided evidence that mean BCVA change using anti-VEGFs was not statistically higher for RCTs (p=0.35) compared to observational studies. Dexamethasone implant showed a trend for better results in observational studies over RCTs. Populations following a fixed aflibercept regimen performed better than those following a reactive treatment regimen. Mean BCVA gain was higher in younger populations (p<0.001), with lower baseline BCVA (p<0.0001) and longer diabetes duration (p<0.0001), receiving a higher number of injections (p<0.0001). Conclusion: Intravitreal therapy with anti-VEGFs or dexamethasone implant produces a significant improvement in BCVA at 12 months in patients with DME. Meta-regression identified the modifiable covariates that can be targeted in order to maximize functional results

Infection control measures in ophthalmology during the COVID-19 outbreak: A narrative review from an early experience in Italy

Introduction: The novel coronavirus (SARS-CoV-2) is infecting people and spreading easily from person-to-person. Cases have been detected in most countries worldwide. Italy is one of the most affected countries as of 30 March 2020. Public health response includes a rapid reorganization of the Italian National Healthcare System in order to reduce transmission of COVID-19 within hospitals and healthcare facilities, while optimizing the assistance to patients with severe COVID-19 complications. Methods: We analysed the actions that were taken in three ophthalmology centres in northern Italy during the SARS-CoV-2 outbreak and how these measures affected patient\u2019s attendance. In addition, due to the rapidly evolving scenario, we reviewed the evidence available during the course of this pandemic. Results: A full reorganization of ophthalmology services is mandatory according to current existing infection containment measures in order to continue dispensing urgent procedures without endangering the community with amplification of the diffusion chain. Ophthalmologists are considered at elevated risk of exposure when caring patients and vice versa, due to their close proximity during eye examination. High volumes of procedures typically generated by ophthalmologists with concurrent implications on the risk of infection are considered when re-assessing healthcare facilities reorganization. Conclusion: Containment measures in the event of pandemic due to infective agents should be well known by healthcare professionals and promptly applied in order to mitigate the risk of nosocomial transmission and outbreak

The Star Formation Rate Intensity Distribution Function--Implications for the Cosmic Star Formation Rate History of the Universe

We address the effects of cosmological surface brightness dimming on observations of faint galaxies by examining the distribution of "unobscured" star formation rate intensities versus redshift. We use the star formation rate intensity distribution function to assess the ultraviolet luminosity density versus redshift, based on our photometry and photometric redshift measurements of faint galaxies in the HDF and the HDF--S WFPC2 and NICMOS fields. We find that (1) previous measurements have missed a dominant fraction of the ultraviolet luminosity density of the universe at high redshifts by neglecting cosmological surface brightness dimming effects, which are important at redshifts larger than z = 2, (2) the incidence of the highest intensity star forming regions increases monotonically with redshift, and (3) the ultraviolet luminosity density plausibly increases monotonically with redshift through the highest redshifts observed. By measuring the spectrum of the luminosity density versus redshift, we also find that (4) previous measurements of the ultraviolet luminosity density at redshifts z < 2 must be reduced by a factor 2 to allow for the spectrum of the luminosity density between rest-frame wavelengths 1500 and 2800 A. And by comparing with observations of high-redshift damped Lyman-alpha absorption systems detected toward background QSOs, we further find that (5) the distribution of star formation rate intensities matches the distribution of neutral hydrogen column densities at redshifts z = 2 through 5, which establishes a quantitative connection between high-redshift galaxies and high column density gas and suggests that high-redshift damped Lyman-alpha absorption systems trace lower star formation rate intensity regions of the same galaxies detected in star light in the HDF and HDF--S.Comment: 28 pages, 9 figures; accepted for publication in the Astrophysical Journa

Morphological number-count and redshift distributions to I < 26 from the Hubble Deep Field: Implications for the evolution of Ellipticals, Spirals and Irregulars

We combine the photometric redshift data of Fernandez-Soto et al. (1997) with the morphological data of Odewahn et al. (1996) for all galaxies with I < 26.0 detected in the Hubble Deep Field. From this combined catalog we generate the morphological galaxy number-counts and corresponding redshift distributions and compare these to the predictions of high normalization zero- and passive- evolution models. From this comparison we conclude the following: (1) E/S0s are seen in numbers and over a redshift range consistent with zero- or minimal passive- evolution to I = 24. Beyond this limit fewer E/S0s are observed than predicted implying a net negative evolutionary process --- luminosity dimming, disassembly or masking by dust --- at I > 24. (2) Spiral galaxies are present in numbers consistent with zero- evolution predictions to I = 22. Beyond this magnitude some net- positive evolution is required. Although the number-counts are consistent with the passive-evolution predictions to I=26.0 the redshift distributions favor number AND luminosity evolution. (3) There is no obvious explanation for the late-type/irregular class and this category requires further subdivision. While a small fraction of the population lies at low redshift (i.e. true irregulars), the majority lie at redshifts, 1 < z < 3. At z > 1.5 mergers are frequent and, taken in conjunction with the absence of normal spirals at z > 2, the logical inference is that they represent the progenitors of normal spirals forming via hierarchical merging.Comment: Accepted for publication in ApJ Letters, colour plates available from http://www.phys.unsw.edu.au/~spd/bib.htm