Tension-Compression Fatigue of an Oxide/Oxide Ceramic Matrix Composite at Elevated Temperature in Air and Steam Environments

Tension-compression fatigue behavior of an oxide-oxide ceramic matrix composite was investigated at 1200°C in air and steam. The composite is comprised of an alumina matrix reinforced with Nextel 720 fibers woven in an eight harness satin weave. The composite relies on a porous matrix for damage tolerance. Compression and tension tests to failure were conducted to characterize basic mechanical properties. Tension-compression fatigue tests were performed at 1 Hz frequency with a ratio of minimum to maximum stress of -1. Maximum stresses ranged from 60-120 MPa. Fatigue run-out (defined as 105 cycles) was achieved in air at 80 MPa and in steam at 70 MPa. Specimens subjected to 105 fatigue cycles in air retained 100% tensile strength. Steam reduced fatigue lives one order of magnitude and tensile strength 17-38%. Tension-compression fatigue lowered fatigue lives three orders of magnitude from published tension-tension fatigue lives. In air, tension-compression fatigue was shown to be more damaging than creep. The post-test composites microstructure was examined. Failure mechanisms were identified and fracture surface morphologies were characterized. The dominant failure mode under tension-compression fatigue was fiber micro-buckling. Shortened composite lives were associated with planar fractures and coordinated fiber failure due to increased fiber-matrix bonding and matrix densification

Edge Guided Reconstruction for Compressive Imaging

We propose EdgeCS—an edge guided compressive sensing reconstruction approach—to recover images of higher quality from fewer measurements than the current methods. Edges are important image features that are used in various ways in image recovery, analysis, and understanding. In compressive sensing, the sparsity of image edges has been successfully utilized to recover images. However, edge detectors have not been used on compressive sensing measurements to improve the edge recovery and subsequently the image recovery. This motivates us to propose EdgeCS, which alternatively performs edge detection and image reconstruction in a mutually beneficial way. The edge detector of EdgeCS is designed to faithfully return partial edges from intermediate image reconstructions even though these reconstructions may still have noise and artifacts. For complex-valued images, it incorporates joint sparsity between the real and imaginary components. EdgeCS has been implemented with both isotropic and anisotropic discretizations of total variation and tested on incomplete k-space (spectral Fourier) samples. It applies to other types of measurements as well. Experimental results on large-scale real/complex-valued phantom and magnetic resonance (MR) images show that EdgeCS is fast and returns high-quality images. For example, it exactly recovers the 256×256 Shepp–Logan phantom from merely 7 radial lines (3.03% k-space), which is impossible for most existing algorithms. It is able to accurately reconstruct a 512 × 512 MR image with 0.05 white noise from 20.87% radial samples. On complex-valued MR images, it obtains recoveries with faithful phases, which are important in many medical applications. Each of these tests took around 30 seconds on a standard PC. Finally, the algorithm is GPU friendly

Current Options for the Treatment of Food Allergy

Food allergy is increasing in prevalence; as a result, there is intense focus on developing safe and effective therapies. Current methods of specific immunotherapy include oral, sublingual, and epicutaneous, while nonspecific methods that have been investigated include: Chinese herbal medicine, probiotics, and anti-IgE antibodies. Although some studies have demonstrated efficacy in inducing desensitization, questions regarding safety and the potential for achieving immune tolerance remain. Although some of these therapies demonstrate promise, further investigation is required before their incorporation into routine clinical practice

Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia

Microglia are myeloid cells of the central nervous system (CNS) that participate both in normal CNS function and disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that were uniquely or highly expressed in microglia vs. myeloid and other immune cells. Out of 239 genes, 106 were enriched in microglia as compared to astrocytes, oligodendrocytes and neurons. This microglia signature was not observed in microglial lines or in monocytes recruited to the CNS and was also observed in human microglia. Based on this signature, we found a crucial role for TGF-β in microglial biology that included: 1) the requirement of TGF-β for the in vitro development of microglia that express the microglial molecular signature characteristic of adult microglia; and 2) the absence of microglia in CNS TGF-β1 deficient mice. Our results identify a unique microglial signature that is dependent on TGF-β signaling which provides insights into microglial biology and the possibility of targeting microglia for the treatment of CNS disease

Shifting Characterizations of the ‘Common People’ in Modern English Retranslations of Thucydides’ History of the Peloponnesian War: A corpus-based analysis

Little research has yet explored the impact of (re)translation on narrative characterization, that is, on the process through which the various actors depicted in a narrative are attributed particular traits and qualities. Moreover, the few studies that have been published on this topic are either rather more anecdotal than systematic, or their focus is primarily on the losses in character information that inevitably occur when a narrative is retold for a new audience in a new linguistic context. They do not explore how the translator’s own background knowledge and ideological beliefs might affect the characterization process for readers of their target-language text. Consequently, this paper seeks to make two contributions to the field: first, it presents a corpus-based methodology developed as part of the Genealogies of Knowledge project for the comparative analysis of characterization patterns in multiple retranslations of a single source text. Such an approach is valuable, it is argued, because it can enhance our ability to engage in a more systematic manner with the accumulation of characterization cues spread throughout a narrative. Second, the paper seeks to move discussions of the effects of translation on narrative characterization away from a paradigm of loss, deficiency and failure, promoting instead a perspective which embraces the productive role translators often play in reconfiguring the countless narratives through which we come to know, imagine and make sense of the past, our present and futures. The potential of this methodology and theoretical standpoint is illustrated through a case study exploring changes in the characterization of ‘the common people’ in two English-language versions of classical Greek historian Thucydides’ History of the Peloponnesian War, the first produced by Samuel Bloomfield in 1829 and the second by Steven Lattimore in 1998. Particular attention is paid to the referring expressions used by each translator—such as the multitude vs. the common people—as well as the specific attributes assigned to this narrative actor. In this way, the study attempts to gain deeper insight into the ways in which these translations reflect important shifts in attitudes within key political debates concerning the benefits and dangers of democracy

Tumour brain: pre‐treatment cognitive and affective disorders caused by peripheral cancers

People that develop extracranial cancers often display co-morbid neurological disorders, such as anxiety, depression and cognitive impairment, even before commencement of chemotherapy. This suggests bidirectional crosstalk between non-CNS tumours and the brain, which can regulate peripheral tumour growth. However, the reciprocal neurological effects of tumour progression on brain homeostasis are not well understood. Here, we review brain regions involved in regulating peripheral tumour development and how they, in turn, are adversely affected by advancing tumour burden. Tumour-induced activation of the immune system, blood–brain barrier breakdown and chronic neuroinflammation can lead to circadian rhythm dysfunction, sleep disturbances, aberrant glucocorticoid production, decreased hippocampal neurogenesis and dysregulation of neural network activity, resulting in depression and memory impairments. Given that cancer-related cognitive impairment diminishes patient quality of life, reduces adherence to chemotherapy and worsens cancer prognosis, it is essential that more research is focused at understanding how peripheral tumours affect brain homeostasis

Halleluja Amsterdam. Deel A. Coen- en Vlothaven

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