46 research outputs found

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    Worldwide, there are 27 million victims of trafficking. With that in mind, this project intended to help students (a) gain an understanding of social issues throughout the world, (b) become activists on behalf of victims of social injustice, and (c) educate others about social injustice and what can be done to reform it. A 26-item survey assessed student knowledge about trafficking. Clemson students correctly answered just over half of the survey questions (M = 16.84; SD = 2.37). The team then designed activities to raise awareness about trafficking. Activities included a venue for students to create Valentine\u27s for trafficking victims, a campus showing of the film Not My Life and an invited speaker an expert on trafficking. At all events bookmarks containing survey results were distributed

    1 THE PORTER HYPOTHESIS AT 20: CAN ENVIRONMENTAL REGULATION ENHANCE INNOVATION AND COMPETITIVENESS?

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    on an earlier draft. Funding from INRA, FQRSC and the chair on “Sustainable Finance and Responsible Investments ” is gratefully acknowledged. All errors remain those of the authors.

    Safety and immunogenicity of attenuated Salmonella enterica serovar Typhimurium delivering an HIV-1 Gag antigen via the Salmonella Type III secretion system �

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    Background: CKS257 (Salmonella typhimurium SL1344 ∆phoP/phoQ ∆ aroA ∆asd ∆strA/strB pSB2131) is a live oral vaccine vector expressing HIV Gag. Methods: HIV Gag was expressed as a fusion protein of a Salmonella Type III secretion system protein SopE, from a balanced lethal asdbased plasmid. Eighteen healthy adults were given single escalating oral doses of 5 × 10 6 to 1 × 10 10 CFU of CKS257 and were monitored for clinical events, shedding and immune responses. Results: Adverse events were mild except at the highest dose. Volunteers shed the organism an average of 5.1 days (range 0–13 days). Eighty-three percent (15/18) of subjects had a mucosal immune response to Salmonella LPS and flagella by IgA ELISPOT assay. Seventy-two percent (13/18) of subjects seroconverted to Salmonella antigens. No volunteer had a response to recombinant Gag as measured by serology, IgA ELISPOT, or immediate ex vivo �-interferon ELISPOT response to Gag peptide pools. Two volunteers responded to Gag peptides by IL-2 ELISPOT, and 4 of 10 volunteers receiving ≥5 × 10 8 CFU had a response to HIV peptides in a cultured �-interferon ELISPOT assay. Conclusions: Although immunogenicity of the HIV antigen needs augmentation, the attenuated Salmonella strain proved to be an excellent platform for vaccine development
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