The Apollo 14 docking anomaly

Six docking attempts were required to achieve initial latch engagement during the Apollo 14 translunar docking event. Although subsequent performance of the docking hardware was normal, the docking probe was retained for a thorough postflight investigation. Pertinent design details of the docking system, the mission events related to the anomaly, and a discussion of the postflight investigation of the cause of the anomaly are presented

Animal Organs in Humans: Uncalculated Risks and Unanswered Questions

This report, produced jointly by the British Union for the Abolition of Vivisection and Compassion in World Farming, fills a number of significant gaps in the current debate about xenotransplantation. In this report we also summarise the ethical and welfare issues concerning experiments on animals for xenotransplant research and their possible use as source animals for organs. Both these aspects are responsible for much pain and distress caused to many animals. We prefer the term “source animals” to “donor animals”, because animals do not choose to donate their organs for xenotransplantation

Remote sensing applications in forestry - The development of an earth resources information system using aerial photographs and digital computers Annual progress report

Earth resources information system using aerial photographs and digital computer

Remote sensing applications in forestry. The development of an earth resources information system using aerial photographs and digital computers photographs and digital computers

Remote aerial sensing and automatic mapping for forest resources information syste

T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva (TM)): Mechanisms of action

Psoriasis is a chronic, incurable, auto-immune disorder with cutaneous manifestations. New evidence on the central role of the immune system in the pathogenesis of psoriasis increasingly provides insight into pathogenic steps that can be modulated to provide disease control. Numerous biological therapies are in various stages of clinical development, with expectation of providing enhanced safety and efficacy over currently available psoriasis therapies. Efalizumab, a recombinant humanized monoclonal IgG1 antibody, is a novel targeted T-cell modulator that inhibits multiple steps in the immune cascade that result in the production and maintenance of psoriatic plaques, including initial T-cell activation and T-cell trafficking into sites of inflammation, including psoriatic skin, with subsequent reactivation in these sites. This article reviews the pharmacodynamic, pharmacokinetic and clinical effects observed during phase I, II and III efalizumab trials in patients with moderate to severe chronic plaque psoriasis. Copyright (C) 2004 S. Karger AG, Basel

Contributions from DMS and ship emissions to CCN observed over the summertime North Pacific

Measurements of cloud condensation nuclei (CCN) made over the North Pacific Ocean in July 2002 are analysed with concurrent measurements of aerosol number, mass and composition. Overall the CCN are controlled by the sulphate, including one case that suggests particle nucleation and growth resulting from dimethyl sulphide oxidation that enhanced CCN concentrations. Hourly CCN concentrations are correlated with concentrations of sulphate plus methanesulphonic acid (MSA) over the entire study period (<i>r</i><sup>2</sup>=0.43 and 0.52 for supersaturations of 0.34% and 0.19%, respectively), and are not well correlated with other organics (<i>r</i><sup>2</sup><0.2). One case study reveals elevated mass and number concentrations of ultrafine and fine organic particles due to regional ship emissions, identified through quadrupole aerosol mass spectrometer (Q-AMS) measurements, during which organic mass concentrations are correlated with CCN values (<i>r</i><sup>2</sup>=0.39 and 0.46 for supersaturations of 0.19% and 0.34%, respectively). The evolution of the time series and mass distributions of organics, sulphate and MSA over this timeframe indicate that the regional distribution of small, diffuse ship-sourced organic particles act as condensation sites for sulphur species, resulting in a subsequent increase in number concentrations of CCN. We conclude that, where present, direct emissions of anthropogenic organic particles may exert a strong control on marine CCN concentrations once diffused into the marine atmosphere, by acting as condensation sites for biogenic and anthropogenic sulphur species

Mapping the Scottish Reformation: Tracing Careers of the Scottish Clergy, 1560-1689

This article introduces readers to Mapping the Scottish Reformation, a digital prosopography of ministers who served in the Church of Scotland between the Reformation Parliament of 1560 to the Revolution in 1689. By extracting data from thousands of pages of ecclesiastical court records held by the National Records of Scotland, Mapping the Scottish Reformation (MSR) tracks clerical careers, showing where they were educated, how they moved between parishes, their age, their marital status, and their disciplinary history. This early modern data drives a powerful mapping engine that will allow users to build their own searches to track clerical careers over time andspace. In short, Mapping the Scottish Reformation puts clerical careers – and, indeed, Scottish religious history more generally – quite literally on the map