The peripartum management of a 32-year-old patient presenting at 34 weeks’ gestation with unrepaired cyanotic heart disease

CITATION: Rossouw, J. N., et al. 2018. The peripartum management of a 32-year-old patient presenting at 34 weeks’ gestation with unrepaired cyanotic heart disease. South African Journal of Obstetrics and Gynaecology, 24(2):36-39, doi:10.7196/sajog.1265.The original publication is available at http://www.sajog.org.zaENGLISH ABSTRACT: Unrepaired cyanotic heart disease is considered a high-risk lesion owing to the consequent increase in maternal and fetal complications. In the presence of pulmonary hypertension, maternal mortality approaching 50% has been reported, and pregnancy is therefore considered contraindicated. We present a case of a 32-year-old woman presenting at 34 weeks’ gestation in heart failure due to newly diagnosed cyanotic complex cardiac disease. The diagnosis of left atrial isomerism with a common atrium, single atrioventricular valve, and a restrictive ventricular septum defect was made. Cyanosis was due to mixing at atrial level, without features of Eisenmenger’s syndrome. Her intrapartum multidisciplinary management is described in detail. The patient was discharged home in a condition similar to her baseline, together with her healthy neonate.http://www.sajog.org.za/index.php/SAJOG/article/view/1265Publisher's versio

Supramolecular Assembly of Pyrene-DNA Conjugates into Columnar Vesicles

This poster describes the supramolecular assembly of DNA conjugates functionalized with pyrene sticky-ends. After hybridization, the 3’-end modified DNA single strands self-assembled into vesicles with diameters of 50–200 nm. Columnar packed aggregated and multilamellar vesicles were observed by cryo-EM

SM and MSSM Higgs Boson Production: Spectra at large transverse Momentum

Strategies for Higgs boson searches require the knowledge of the total production cross section and the transverse momentum spectrum. The large transverse momentum spectrum of the Higgs boson produced in gluon fusion can be quite different in the Standard Model and the Minimal Supersymmetric Standard Model. In this paper we present a comparison of the Higgs transverse momentum spectrum obtained using the PYTHIA event generator and the HIGLU program as well as the program HQT, which includes NLO corrections and a soft gluon resummation for the region of small transverse momenta. While the shapes of the spectra are similar for the Standard Model, significant differences are observed in the spectra of Minimal Supersymmetric Standard Model benchmark scenarios with large tan(beta).Comment: 8 pages, 13 figure

Production of the neutral top-pion πt0\pi_{t}^{0} in association with a high-pTp_{T} jet at the LHCLHC

In the framework of the topcolor-assisted technicolor $(TC2)$ model, we study production of the neutral top-pion $\pi_{t}^{0}$ in association with a high-$p_{T}$ jet at the $LHC$, which proceeds via the partonic processes $gg\longrightarrow \pi_{t}^{0}g$, $gq\longrightarrow \pi_{t}^{0}q$, $q\bar{q}\longrightarrow \pi_{t}^{0}g$, $gb(\bar{b})\longrightarrow \pi_{t}^{0}b(\bar{b})$, and $b\bar{b}\longrightarrow \pi_{t}^{0}g$. We find that it is very challenging to detect the neutral top-pion $\pi_{t}^{0}$ via the process $pp\longrightarrow \pi_{t}^{0}+jet+X\to t\bar{t}+jet+X$, while the possible signatures of $\pi_{t}^{0}$ might be detected via the process $pp\longrightarrow \pi_{t}^{0}+jet+X\to(\bar{t}c+t\bar{c})+jet+X$ at the $LHC$.Comment: 13 pages, 4 figures; typos correcte

Signal height in silicon pixel detectors irradiated with pions and protons

Pixel detectors are used in the innermost part of multi purpose experiments at the Large Hadron Collider (LHC) and are therefore exposed to the highest fluences of ionising radiation, which in this part of the detectors consists mainly of charged pions. The radiation hardness of the detectors has thoroughly been tested up to the fluences expected at the LHC. In case of an LHC upgrade the fluence will be much higher and it is not yet clear up to which radii the present pixel technology can be used. In order to establish such a limit, pixel sensors of the size of one CMS pixel readout chip (PSI46V2.1) have been bump bonded and irradiated with positive pions up to 6E14 Neq/cm^2 at PSI and with protons up to 5E15 Neq/cm^2. The sensors were taken from production wafers of the CMS barrel pixel detector. They use n-type DOFZ material with a resistance of about 3.7kOhm cm and an n-side read out. As the performance of silicon sensors is limited by trapping, the response to a Sr-90 source was investigated. The highly energetic beta-particles represent a good approximation to minimum ionising particles. The bias dependence of the signal for a wide range of fluences will be presented.Comment: Contribution to the 7th International Conference on Radiation Effects on Semiconductor Materials, Detectors and Devices October 15-17, 2008 Firenze, Ital

Nondestructive in-line sub-picomolar detection of magnetic nanoparticles in flowing complex fluids

Over the last decades, the use of magnetic nanoparticles in research and commercial applications has increased dramatically. However, direct detection of trace quantities remains a challenge in terms of equipment cost, operating conditions and data acquisition times, especially in flowing conditions within complex media. Here we present the in-line, non-destructive detection of magnetic nanoparticles using high performance atomic magnetometers at ambient conditions in flowing media. We achieve sub-picomolar sensitivities measuring $\sim$30 nm ferromagnetic iron and cobalt nanoparticles that are suitable for biomedical and industrial applications, under flowing conditions in water and whole blood. Additionally, we demonstrate real-time surveillance of the magnetic separation of nanoparticles from water and whole blood. Overall our system has the merit of inline direct measurement of trace quantities of ferromagnetic nanoparticles with so far unreached sensitivities and could be applied in the biomedical field (diagnostics and therapeutics) but also in the industrial sector

Linear Peptides-A Combinatorial Innovation in the Venom of Some Modern Spiders

In the venom of spiders, linear peptides (LPs), also called cytolytical or antimicrobial peptides, represent a largely neglected group of mostly membrane active substances that contribute in some spider species considerably to the killing power of spider venom. By next-generation sequencing venom gland transcriptome analysis, we investigated 48 spider species from 23 spider families and detected LPs in 20 species, belonging to five spider families (Ctenidae, Lycosidae, Oxyopidae, Pisauridae, and Zodariidae). The structural diversity is extraordinary high in some species: the lynx spider Oxyopes heterophthalmus contains 62 and the lycosid Pardosa palustris 60 different LPs. In total, we identified 524 linear peptide structures and some of them are in lycosids identical on amino acid level. LPs are mainly encoded in complex precursor structures in which, after the signal peptide and propeptide, 13 or more LPs (Hogna radiata) are connected by linkers. Besides Cupiennius species, also in Oxyopidae, posttranslational modifications of some precursor structures result in the formation of two-chain peptides. It is obvious that complex precursor structures represent a very suitable and fast method to produce a high number and a high diversity of bioactive LPs as economically as possible. At least in Lycosidae, Oxyopidae, and in the genus Cupiennius, LPs reach very high Transcripts Per Kilobase Million values, indicating functional importance within the envenomation process

The Physics of Heavy Flavours at SuperB

This is a review of the SuperB project, covering the accelerator, detector, and highlights of the broad physics programme. SuperB is a flavour factory capable of performing precision measurements and searches for rare and forbidden decays of $B_{u,d,s}$, $D$, $\tau$ and $\Upsilon({\mathrm{nS}})$ particles. These results can be used to test fundamental symmetries and expectations of the Standard Model, and to constrain many different hypothesised types of new physics. In some cases these measurements can be used to place constraints on the existence of light dark matter and light Higgs particles with masses below $10GeV/c^2$. The potential impact of the measurements that will be made by SuperB on the field of high energy physics is also discussed in the context of data taken at both high energy in the region around the \Upsilon({\mathrm{4S}})$, and near charm threshold.Comment: 49 pages, topical review submitted to J. Phys

The Discovery Potential of a Super B Factory

The Proceedings of the 2003 SLAC Workshops on flavor physics with a high luminosity asymmetric e+e- collider. The sensitivity of flavor physics to physics beyond the Standard Model is addressed in detail, in the context of the improvement of experimental measurements and theoretical calculations.Comment: 476 pages. Printed copies may be obtained by request to [email protected] . arXiv admin note: v2 appears to be identical to v

Multi-Jet Event Rates in Deep Inelastic Scattering and Determination of the Strong Coupling Constant

Jet event rates in deep inelastic ep scattering at HERA are investigated applying the modified JADE jet algorithm. The analysis uses data taken with the H1 detector in 1994 and 1995. The data are corrected for detector and hadronization effects and then compared with perturbative QCD predictions using next-to-leading order calculations. The strong coupling constant alpha_S(M_Z^2) is determined evaluating the jet event rates. Values of alpha_S(Q^2) are extracted in four different bins of the negative squared momentum transfer~\qq in the range from 40 GeV2 to 4000 GeV2. A combined fit of the renormalization group equation to these several alpha_S(Q^2) values results in alpha_S(M_Z^2) = 0.117+-0.003(stat)+0.009-0.013(syst)+0.006(jet algorithm).Comment: 17 pages, 4 figures, 3 tables, this version to appear in Eur. Phys. J.; it replaces first posted hep-ex/9807019 which had incorrect figure 4