Reproductive management in pigs: emphasis on the different roles of the boar and on optimal insemination management

Boars have different roles in the reproductive management in pigs. Boar contact can stimulate follicle development and thereby induce oestrus, both in gilts and sows. Boar contact during oestrus is essential for good oestrus expression, which is essential for the correct timing of insemination and the proper use of boar contact during insemination can stimulate sperm transport and thereby fertilisation. Stimulation by boars clearly has an olfactory component (the boar smell), but can also have an auditory, visual and evn tactile component. The background of the different roles and some of these different components of the boar are discussed. To enable a good farrowing rate and litter size, sows should be inseminated between 0 and 24h before ovulation. However, it is not possible to accurately predict the time of ovulation in sows. Although ovulation takes place at a relatively fixed 60-75% of the duration of oestrus, the duration of oestrus varies considerably between sows and between farms, resulting in a variable ovulation time from onset of oestrus. Therefore, most farmers inseminate their sows every day of oestrus to ensure insemination within the optimal period. Since post-ovulation inseminations should be avoided, it is adviced to only inseminate sows while they still show an optimal standing respons

Intermittent suckling with or without co-mingling of non-littermate piglets before weaning improves piglet performance in the immediate post-weaning period when compared with conventional weaning

Background: In this experiment, intermittent suckling (IS) with or without the co-mingling (CoM) of piglets was studied as a method to stimulate solid feed intake and reduce post-weaning stress. Methods: Three weaning regimes using 30 multiparous sows were compared: (1) conventional weaning (CW) (n = 10 litters), where piglets had continuous access to the sow until weaning (d 0, farrowing = d −25 relative to weaning); (2) intermittent suckling (IS) (n = 10 litters), where piglets were separated from the sow for 8 h/d starting at d −7 (relative to weaning); and (3) intermittent suckling with co-mingling (ISCo) (n = 10 litters) where IS started at d −7 and two litters were housed together during separation and then returned to their original sow. Ad libitum creep feed was available from d −17. At weaning pigs were housed in pens of 11 pigs, 27 pens in total. The ISCo treatment was divided in half to examine effects of different mixing strategies after weaning. Half of the ISCo litters were kept in familiar groups (ISCoF, familiar, n = 4) and the other half were mixed within treatment resulting in groups of unfamiliar pigs (ISCoNF, not familiar, n = 5), the same as IS (n = 9) and CW (n = 9) treatments. Results: The ISCo piglets ate more creep feed in the week before weaning (P < 0.01), but also showed more aggressive and manipulative behaviour on first day of CoM compared with CW piglets (P < 0.05). IS with or without CoM increased exploratory and play behaviour on the first day of treatment intervention (P < 0.001) and increased sleeping behaviour on the last day of treatment intervention compared with CW (P < 0.001). Mixing strategy at weaning had an effect on performance data with the highest growth and feed intake seen in ISCoF pigs 2 to 8 d after weaning (P <0.001). IS and ISCoNF pigs also grew faster and ate more than CW pigs 2 to 8 d after weaning (P < 0.001). Post-weaning injury scores suggested reduced aggression in ISCo as evidenced by reduced redness (skin irritation) (P < 0.05), and a tendency for ISCo to have less scratches than CW (P < 0.1). The IS pigs slept the most and displayed less manipulative behaviours on the day of weaning and plasma haptoglobin levels remained low in IS pigs after weaning (P ≤ 0.01). Conclusions: Both intermittent suckling techniques improved production indices in the immediate post-weaning period. However, the addition of co-mingling before weaning in combination with grouping familiar pigs together after weaning improved performance in an additive manner

Ranking of Fuzzy Similar Faces Using Relevance Matrix and Aggregation Operators

AbstractIn perception based imaging, Sketching With Words (SWW) is a well-established methodology in which the objects of computation are fuzzy geometric objects (f-objects).The problem of facial imaging of criminal on the basis of onlooker statement is not lack of method and measures but the modeling of onlooker(s) mind set. Because the onlooker has to give statements about different human face parts like forehead, eyes, nose, and chin etc.The concept of fuzzy similarity (f-similarity) and proper aggregation of components of face may provide more flexibility to onlooker(s). In proposed work onlooker(s) statement is recorded. Thereafter it is compared with existing statements. The f-similarity with different faces in database is estimated by using ‘as many as possible’ linguistic quantifier. Three types of constraints over size of parts of face ‘small’, ‘medium’, and ‘large’ are considered. Possibilistic constraints with linguistic hedges and negation operator like ‘very long’, ‘not long’, ‘not very long’ etc. are used. Moreover we have generated ranking of alike faces in decreasing order by using the concepts of f-similarity and relevance matrix

Improving welfare and production in the peri-weaning period: Effects of co-mingling and intermittent suckling on the stress response, performance, behaviour, and gastrointestinal tract carbohydrate absorption in young pigs

We investigated the effect of different pre-weaning interventions on performance, aspects of behaviour, and selected neuroendocrine, inflammatory and immune indices in 593 weanling pigs (59 litters, weaning age 22 ± 1.7). Measurements were taken at various time points two weeks before and after weaning. Sugar absorption tests (20% mannitol and 20% galactose solutions) were used to assess gastrointestinal tract (GIT) absorptive capacity. One week before weaning, litters were either co-mingled (CoM) for 8 h daily with another litter or not co-mingled (NoCoM). Half of the litters were also subjected to intermittent suckling (IS) involving separation from their sow for 8 h daily and the other half remained with their sow (NoIS). Hence, four treatments were produced in a 2×2 factorial design; (1) CoM IS (n = 16 litters), (2) CoM NoIS (n = 14 litters), (3) NoCoM IS (n = 16 litters), (4) NoCoM NoIS (n = 13 litters). Measurements are compared within each of the main effects (CoM or IS) unless otherwise stated. Acute weaning stress was evidenced by increases in cortisol, haptoglobin and N: L ratios when data were combined (P < 0.001). However, there were tendencies (P < 0.1) for lower cortisol in IS pigs and higher N: L ratios in CoM pigs at weaning. While CoM did not affect performance before weaning, growth (P < 0.05), feed intake (P < 0.05) and body weight (P < 0.05) were reduced in CoM pigs 7-14 days after weaning. One week of IS before weaning improved feed intake before weaning (P < 0.01), resulting in better growth (P = 0.01) and a tendency (P < 0.1) for a higher feed intake 2-7 days after weaning. Co-mingled piglets had more scratches 4 days before weaning (P < 0.001), but tended to have fewer scratches 2 days after weaning (P < 0.1). Pigs exposed to either IS or CoM displayed more sleeping behaviour the day after weaning (P < 0.01 and P < 0.001). A higher mannitol absorption was evident in CoM NoIS pigs 3 days after weaning (P < 0.01), and galactose absorption was reduced in IS pigs 3 days before weaning (P < 0.05) and tended to be reduced 3 days after weaning (P < 0.1), likely reflecting a GIT adaptive response. Overall, despite improvements in mannitol absorption and behaviour, there was no beneficial effect of CoM on performance after weaning. Alternatively, IS improved behaviour and performance during the first week after weaning

Is there a future for the boar? : the role of boar stimuli in reproductive processes around estrus in the pig

This thesis describes several boar stimuli in their potency to elicit estrous behavior and their potency to affect uterine contractility. With different levels of boar stimuli, onset of estrus can be recorded at different time points relative to ovulation, depending on the change in responsiveness of sows to the stimuli. However, the onset of estrus recorded in such ways, as well as the change in responsiveness recorded by using different stimuli to induce estrous behavior, appeared to be bad predictors for the time of ovulation. Time of ovulation is important for the success of insemination. The use of a back pressure test in the presence of a boar appeared to be most appropriate for detection of estrus, as with lower levels of boar stimuli the chance of not detecting estrus increases, and higher levels of stimuli did not add to the efficiency of estrus detection due to habituation. Uterine contractility is increased during estrus and is important for sperm transport, as suppression of uterine contractility reduces fertilisation rate. Stimulation of uterine contractility to a high degree on the other hand, can obstruct the uptake of the inseminate and increase the reflux of semen. Presence of a boar is more potent than 5-androstenon or tactile stimuli in inducing the release of oxytocin and in stimulating uterine contractility. Moreover, boar presence selectively stimulates uterine contractility only in sows that have a below average uterine contractility, and might therefore be an appropriate way of stimulating uterine contractility during insemination

MUC5B levels in submandibular gland saliva of patients treated with radiotherapy for head-and-neck cancer: A pilot study

<p>Abstract</p> <p>Background</p> <p>The salivary mucin MUC5B, present in (sero)mucous secretions including submandibular gland (SMG) saliva, plays an important role in the lubrication of the oral mucosa and is thought to be related to the feeling of dry mouth. We investigated if MUC5B levels in SMG saliva could distinguish between the presence or absence of severe dry mouth complaints 12 months after radiotherapy (RT) for head-and-neck cancer (HNC).</p> <p>Findings</p> <p>Twenty-nine HNC patients with a residual stimulated SMG secretion rate of ≥0.2 ml/10 min at 12 months after RT were analyzed. MUC5B (in U; normalized to 1) and total protein levels (mg/ml) were measured in SMG saliva at baseline and 12 months after RT using ELISA and BCA protein assay, respectively. Overall, median MUC5B levels decreased after RT from 0.12 to 0.03 U (<it>p</it> = 0.47). Patients were dichotomized into none/mild xerostomia (n = 12) and severe xerostomia (n = 17) based on a questionnaire completed at 12 months. SMG and whole saliva flow rates decreased after RT but were comparable in both groups. The median MUC5B level was higher in patients with no or mild xerostomia compared to patients with severe xerostomia (0.14 vs 0.01 U, <it>p</it> = 0.22). Half of the patients with severe xerostomia had no detectable MUC5B at 12 months after RT. No differences in total protein levels were observed.</p> <p>Conclusions</p> <p>Qualitative saliva parameters like MUC5B need further investigation in RT-induced xerostomia. This pilot study showed a trend towards lower MUC5B levels in the SMG saliva of patients with severe xerostomia 12 months after RT for HNC.</p

Intermittent suckling in combination with an older weaning age improves growth, feed intake and aspects of gastrointestinal tract carbohydrate absorption in pigs after weaning

This study tested the hypothesis that intermittent suckling (IS) with or without an older weaning age would improve post-weaning gastrointestinal tract (GIT) carbohydrate absorptive capacity in pigs while reducing post-weaning stress and aspects of the inflammatory response. Three weaning regimes using primiparous sows were compared: (1) conventional weaning (CW28) (n = 22), where piglets were weaned conventionally at day 28; (2) IS28 (n = 21), where IS started at day 21 until weaning at day 28; and (3) IS35 (n = 21), where IS started at day 28 until weaning at day 35. Sugar absorption tests (10% mannitol or 10% galactose) were used to measure GIT absorptive capacity. All measured parameters were compared in relation to weaning across treatments (i.e., different physiological ages were compared). The IS35 pigs grew fastest in the 12 days after weaning (p < 0.01) and had the highest solid feed intake before and after weaning (p < 0.05). Irrespective of treatment, pre-weaning mannitol levels were higher than post-weaning levels (p < 0.01), whereas post-weaning galactose levels were highest in IS35 pigs (p < 0.01). Cytokine data did not show any treatment effects. In conclusion, these data suggest that IS in combination with an older weaning age (day 35) improved post-weaning adaptation as evidenced by improvements in performance measures and galactose absorption. However, IS28 did not improve post-weaning performance

Network meta-analysis on the log-hazard scale, combining count and hazard ratio statistics accounting for multi-arm trials: a tutorial.

BACKGROUND: Data on survival endpoints are usually summarised using either hazard ratio, cumulative number of events, or median survival statistics. Network meta-analysis, an extension of traditional pairwise meta-analysis, is typically based on a single statistic. In this case, studies which do not report the chosen statistic are excluded from the analysis which may introduce bias. METHODS: In this paper we present a tutorial illustrating how network meta-analyses of survival endpoints can combine count and hazard ratio statistics in a single analysis on the hazard ratio scale. We also describe methods for accounting for the correlations in relative treatment effects (such as hazard ratios) that arise in trials with more than two arms. Combination of count and hazard ratio data in a single analysis is achieved by estimating the cumulative hazard for each trial arm reporting count data. Correlation in relative treatment effects in multi-arm trials is preserved by converting the relative treatment effect estimates (the hazard ratios) to arm-specific outcomes (hazards). RESULTS: A worked example of an analysis of mortality data in chronic obstructive pulmonary disease (COPD) is used to illustrate the methods. The data set and WinBUGS code for fixed and random effects models are provided. CONCLUSIONS: By incorporating all data presentations in a single analysis, we avoid the potential selection bias associated with conducting an analysis for a single statistic and the potential difficulties of interpretation, misleading results and loss of available treatment comparisons associated with conducting separate analyses for different summary statistics

A prebiotic intervention study in children with autism spectrum disorders (ASDs)

Different dietary approaches, such as gluten and casein free diets, or the use of probiotics and prebiotics have been suggested in autistic spectrum disorders in order to reduce gastrointestinal (GI) disturbances. GI symptoms are of particular interest in this population due to prevalence and correlation with the severity of behavioural traits. Nowadays, there is lack of strong evidence about the effect of dietary interventions on these problems, particularly prebiotics. Therefore, we assessed the impact of exclusion diets and a 6-week Bimuno® galactooligosaccharide (B-GOS®) prebiotic intervention in 30 autistic children. RESULTS: The results showed that children on exclusion diets reported significantly lower scores of abdominal pain and bowel movement, as well as lower abundance of Bifidobacterium spp. and Veillonellaceae family, but higher presence of Faecalibacterium prausnitzii and Bacteroides spp. In addition, significant correlations were found between bacterial populations and faecal amino acids in this group, compared to children following an unrestricted diet. Following B-GOS® intervention, we observed improvements in anti-social behaviour, significant increase of Lachnospiraceae family, and significant changes in faecal and urine metabolites. CONCLUSIONS: To our knowledge, this is the first study where the effect of exclusion diets and prebiotics has been evaluated in autism, showing potential beneficial effects. A combined dietary approach resulted in significant changes in gut microbiota composition and metabolism suggesting that multiple interventions might be more relevant for the improvement of these aspects as well as psychological traits

Physiological changes to the swallowing mechanism following (Chemo)radiotherapy for head and neck cancer: a systematic review

Emerging research suggests that preventative swallowing rehabilitation, undertaken before or during (chemo)radiotherapy ([C]RT), can significantly improve early swallowing outcomes for head and neck cancer (HNC) patients. However, these treatment protocols are highly variable. Determining specific physiological swallowing parameters that are most likely to be impacted post-(C)RT would assist in refining clear targets for preventative rehabilitation. Therefore, this systematic review (1) examined the frequency and prevalence of physiological swallowing deficits observed post-(C)RT for HNC, and (2) determined the patterns of prevalence of these key physiological deficits over time post-treatment. Online databases were searched for relevant papers published between January 1998 and March 2013. A total of 153 papers were identified and appraised for methodological quality and suitability based on exclusionary criteria. Ultimately, 19 publications met the study’s inclusion criteria. Collation of reported prevalence of physiological swallowing deficits revealed reduced laryngeal excursion, base-of-tongue (BOT) dysfunction, reduced pharyngeal contraction, and impaired epiglottic movement as most frequently reported. BOT dysfunction and impaired epiglottic movement showed a collective prevalence of over 75 % in the majority of patient cohorts, whilst reduced laryngeal elevation and pharyngeal contraction had a prevalence of over 50 %. Subanalysis suggested a trend that the prevalence of these key deficits is dynamic although persistent over time. These findings can be used by clinicians to inform preventative intervention and support the use of specific, evidence-based therapy tasks explicitly selected to target the highly prevalent deficits post-(C)RT for HNC