94 research outputs found

    METHOD TO VISUALIZE AND ANALYZE SIMILARITIES OF MOVEMENTS – USING THE EXAMPLE OF KARATE KICKS

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    Most sports movements are very complex. In order to estimate similarities between the movements many biomechanical parameters are necessary. This impairs the clearness of the classification of similar movements. Another variant is the use of nonlinear procedures which allow the consideration of the movement on the whole. But a connection to the single biomechanical parameters is not given. The aim of this paper is to introduce a procedure to visualize the movement coordination to get a visual impression of the whole movement, and in addition further analyses by means of statistical tools to confirm similarities and variabilities between the movements were presented using the example of Mae-Geri

    Ein einfaches Verfahren zur Herstellung anellierter Thiophene

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    A simple method for the synthesis of fused thiophenes by reaction of agr-carboxymethyl substituted cyclic ketones withLawesson-reagent is described. Considerations concerning the reaction mechanism are given

    Diagnosis, classification, and genetics of phenylketonuria and tetrahydrobiopterin (BH4) deficiencies

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    This article summarizes the present knowledge, recent developments, and common pitfalls in the diagnosis, classification, and genetics of hyperphenylalaninemia, including tetrahydrobiopterin (BH4) deficiency. It is a product of the recent workshop organized by the European Phenylketonuria Group in March 2011 in Lisbon, Portugal. Results of the workshop demonstrate that following newborn screening for phenylketonuria (PKU), using tandem mass-spectrometry, every newborn with even slightly elevated blood phenylalanine (Phe) levels needs to be screened for BH4 deficiency. Dried blood spots are the best sample for the simultaneous measurement of amino acids (phenylalanine and tyrosine), pterins (neopterin and biopterin), and dihydropteridine reductase activity from a single specimen. Following diagnosis, the patient's phenotype and individually tailored treatment should be established as soon as possible. Not only blood Phe levels, but also daily tolerance for dietary Phe and potential responsiveness to BH4 are part of the investigations. Efficiency testing with synthetic BH4 (sapropterin dihydrochloride) over several weeks should follow the initial 24-48-hour screening test with 20mg/kg/day BH4. The specific genotype, i.e. the combination of both PAH alleles of the patient, helps or facilitates to determine both the biochemical phenotype (severity of PKU) and the responsiveness to BH4. The rate of Phe metabolic disposal after Phe challenge may be an additional useful tool in the interpretation of phenotype-genotype correlation

    Ueber das Lupus-Carcinom

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