Transferring a Question-Based Dialog Framework to a Distributed Architecture

Inquiry skills are an essential tool for assessing and integrating knowledge. In facilitated face-to-face settings, inquiry skills were improved successfully by using a “question-based dialog” and its resulting visual representation. However, groups that work without a facilitator, or in which members collaborate asynchronously or in different geographical regions, such as Communities of Practice (CoP), cannot schedule face-to-face inquiry meetings. This paper summarises the unmet requirements of CoPs for a collaborative inquiry tool found by previous research on the Noracle model and proposes a distributed Web architecture as a solution. It mitigates the need for a common infrastructure, central coordination or facilitation, addresses the evolutionary nature of communities of practice and reduces the cognitive load for the individual by filtering and organising the representational artefacts with respect to the social network of the community. The implementation we envision in this paper aims at applying the concept to a much broader audience, ultimately replacing the need for local meetings

An Integrated Learning Analytics Approach for Virtual Vocational Training Centers

Virtual training centers are hosted solutions for the implementation of training courses in the form of e.g. Webinars. Many existing centers neglect the informal and social dimension of vocational training as well as the legitimate business interests of training providers and companies sending their employees. In this paper, we present the virtual training center platform V3C that blends formal, certified virtual training courses with self-regulated and social learning in synchronous and asynchronous learning phases. We have developed an integrated learning analytics approach to collect, store, analyze and visualize data for different purposes like certification, interventions and gradual improvement of the platform. The results given here demonstrate the ability of the platform to deliver data for key performance indicators like learning outcomes and drop-out rates as well as the interplay between synchronous and asynchronous learning phases on a very large scale. Since the platform implementation is open source, results can be easily transferred and exploited in many contexts

Late Cenozoic diversification of the austral genus Lagenophora (Astereae, Asteraceae)

Lagenophora (Astereae, Asteraceae) has 14 species in New Zealand, Australia, Asia, southern South America, Gough Island and Tristan da Cunha. Phylogenetic relationships in Lagenophora were inferred using nuclear and plastid DNA regions. Reconstruction of spatio-temporal evolution was estimated using parsimony, Bayesian inference and likelihood methods, a Bayesian relaxed molecular clock and ancestral area and habitat reconstructions. Our results support a narrow taxonomic concept of Lagenophora including only a core group of species with one clade diversifying in New Zealand and another in South America. The split between the New Zealand and South American Lagenophora dates from 11.2 Mya [6.1–17.4 95% highest posterior density (HPD)]. The inferred ancestral habitats were openings in beech forest and subalpine tussockland. The biogeographical analyses infer a complex ancestral area for Lagenophora involving New Zealand and southern South America. Thus, the estimated divergence times and biogeographical reconstructions provide circumstantial evidence that Antarctica may have served as a corridor for migration until the expansion of the continental ice during the late Cenozoic. The extant distribution of Lagenophora reflects a complex history that could also have involved direct long-distance dispersal across southern oceans.Fil: Sancho, Gisela. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Departamento Científico de Plantas Vasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: De Lange, Peter. Ecosystems And Species Unit. Department of Conservation; Nueva ZelandaFil: Donato, Mariano Humberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Limnología "Dr. Raúl A. Ringuelet". Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Instituto de Limnología; ArgentinaFil: Barkla, John. Otago Conservancy; Nueva ZelandaFil: Wagstaff, Steve J.. Allan Herbarium; Nueva Zeland

Prebiotics in human digestion

Analysis of the bacterial flora is important for the characterization of fermentation events. They help the further validation of the “prebiotic index“ as fast and cost-effective screening of prebotic action within individuals or selected populations

Reverse innovation for the new mobility

Draft White Paper Developed for the Rockefeller Foundation (2013)Corresponding Organization: UMTRI-­‐SMART ProgramWorking PaperThe confluence of increasing urbanization with climate change, and the associated need to decarbonize the economy, is driving urgency for the global adoption and diffusion of sustainable scalable solutions. IT-enabled, multi-modal transportation, often referred to as the “new mobility”, is making inroads in developed and emerging economies alike. Local emerging market entrepreneurs as well as multinationals, seeking transformative innovation strategies to open up new markets are engaging in this rapidly growing industry. This has created an opportunity for innovative indigenous firms in emerging economies to either scale internationally on their own or partner with (often Western) multinationals to define frugal products, services, and business models that address recession-constrained Western markets. Part and parcel to this shift in global engagement is the emergence of a new product development strategy, referred to as reverse innovation (RI). Here, we seek to explore the nexus of RI and the new mobility opportunity, by explicitly recognizing the spillover effects of knowledge transfer and economic development through local firms and, more broadly, the supply chains that internationalize. In fact, some Western companies are outsourcing RI to emerging economy partner firms, thus shifting historical cost-based relationships to value-based engagements. At the core, lies a radical shift in how products and processes are designed, to include: stripping out complexity without sacrificing customer experience; a high degree of customization not through features but by re-using underlying platforms; and customization at the latest stage of the value chain so as to not disrupt materials, components, and subsystems. The potential implications of RI designs and business models on the adoption of frugal innovations in the West are explored, and paths to engaging entrepreneurs in emerging economies are highlighted.http://deepblue.lib.umich.edu/bitstream/2027.42/100250/1/102968.pd

Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients

Introduction The aim of this study was to investigate whether in-hospital mortality was associated with the administered fraction of oxygen in inspired air (FiO(2)) and achieved arterial partial pressure of oxygen (PaO(2)). Methods This was a retrospective, observational study on data from the first 24 h after admission from 36,307 consecutive patients admitted to 50 Dutch intensive care units (ICUs) and treated with mechanical ventilation. Oxygenation data from all admission days were analysed in a subset of 3,322 patients in 5 ICUs. Results Mean PaO(2) and FiO(2) in the first 24 h after ICU admission were 13.2 kPa (standard deviation (SD) 6.5) and 50% (SD 20%) respectively. Mean PaO(2) and FiO(2) from all admission days were 12.4 kPa (SD 5.5) and 53% (SD 18). Focusing on oxygenation in the first 24 h of admission, in-hospital mortality was shown to be linearly related to FiO(2) value and had a U-shaped relationship with PaO(2) (both lower and higher PaO(2) values were associated with a higher mortality), independent of each other and of Simplified Acute Physiology Score (SAPS) II, age, admission type, reduced Glasgow Coma Scale (GCS) score, and individual ICU. Focusing on the entire ICU stay, in-hospital mortality was independently associated with mean FiO(2) during ICU stay and with the lower two quintiles of mean PaO(2) value during ICU stay. Conclusions Actually achieved PaO(2) values in ICU patients in The Netherlands are higher than generally recommended in the literature. High FiO(2), and both low PaO(2) and high PaO(2) in the first 24 h after admission are independently associated with in-hospital mortality in ICU patients. Future research should study whether this association is causal or merely a reflection of differences in severity of illness insufficiently corrected for in the multivariate analysis

Converging or Crossing Curves: Untie the Gordian Knot or Cut it? Appropriate Statistics for Non-Proportional Hazards in Decitabine DACO-016 Study (AML)

Introduction: Among patients with acute myeloid leukemia (AML), the DACO-016 randomized study showed reduction in mortality for decitabine [Dacogen® (DAC), Eisai Inc., Woodcliff Lake, NJ, USA] compared with treatment choice (TC): at primary analysis the hazard ratio (HR) was 0.85 (95% confidence interval 0.69-1.04; stratified log-rank P=0.108). With two interim analyses, two-sided alpha was adjusted to 0.0462. With 1-year additional follow-up the HR reached 0.82 (nominal P=0.0373). These data resulted in approval of DAC in the European Union, though not in the United States. Though pre-specified, the log-rank test could be considered not optimal to assess the observed survival difference because of the non-proportional hazard nature of the survival curves. Methods: We applied the Wilcoxon test as a sensitivity analysis. Patients were randomized to DAC (N=242) or TC (N=243). One-hundred and eight (44.4%) patients in the TC arm and 91 (37.6%) patients in the DAC arm selectively crossed over to subsequent disease modifying therapies at progression, which might impact the survival beyond the median with resultant converging curves (and disproportional hazards). Results: The stratified Wilcoxon test showed a significant improvement in median (CI 95%) overall survival with DAC [7.7 (6.2; 9.2) months] versus TC [5.0 (4.3; 6.3) months; P=0.0458]. Conclusion: Wilcoxon test indicated significant increase in survival for DAC versus TC compared to log-rank test. Funding: Janssen-Cilag GmbH

Stubborn Predictions in Primary Visual Cortex

Perceivers can use past experiences to make sense of ambiguous sensory signals. However, this may be inappropriate when the world changes and past experiences no longer predict what the future holds. Optimal learning models propose that observers decide whether to stick with or update their predictions by tracking the uncertainty or "precision" of their expectations. However, contrasting theories of prediction have argued that we are prone to misestimate uncertainty-leading to stubborn predictions that are difficult to dislodge. To compare these possibilities, we had participants learn novel perceptual predictions before using fMRI to record visual brain activity when predictive contingencies were disrupted-meaning that previously "expected" events become objectively improbable. Multivariate pattern analyses revealed that expected events continued to be decoded with greater fidelity from primary visual cortex, despite marked changes in the statistical structure of the environment, which rendered these expectations no longer valid. These results suggest that our perceptual systems do indeed form stubborn predictions even from short periods of learning-and more generally suggest that top-down expectations have the potential to help or hinder perceptual inference in bounded minds like ours

Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients

Introduction The aim of this study was to investigate whether in-hospital mortality was associated with the administered fraction of oxygen in inspired air (FiO(2)) and achieved arterial partial pressure of oxygen (PaO(2)). Methods This was a retrospective, observational study on data from the first 24 h after admission from 36,307 consecutive patients admitted to 50 Dutch intensive care units (ICUs) and treated with mechanical ventilation. Oxygenation data from all admission days were analysed in a subset of 3,322 patients in 5 ICUs. Results Mean PaO(2) and FiO(2) in the first 24 h after ICU admission were 13.2 kPa (standard deviation (SD) 6.5) and 50% (SD 20%) respectively. Mean PaO(2) and FiO(2) from all admission days were 12.4 kPa (SD 5.5) and 53% (SD 18). Focusing on oxygenation in the first 24 h of admission, in-hospital mortality was shown to be linearly related to FiO(2) value and had a U-shaped relationship with PaO(2) (both lower and higher PaO(2) values were associated with a higher mortality), independent of each other and of Simplified Acute Physiology Score (SAPS) II, age, admission type, reduced Glasgow Coma Scale (GCS) score, and individual ICU. Focusing on the entire ICU stay, in-hospital mortality was independently associated with mean FiO(2) during ICU stay and with the lower two quintiles of mean PaO(2) value during ICU stay. Conclusions Actually achieved PaO(2) values in ICU patients in The Netherlands are higher than generally recommended in the literature. High FiO(2), and both low PaO(2) and high PaO(2) in the first 24 h after admission are independently associated with in-hospital mortality in ICU patients. Future research should study whether this association is causal or merely a reflection of differences in severity of illness insufficiently corrected for in the multivariate analysis

Development and validation of a psychometric scale for assessing PA chest image quality

Purpose - To develop and validate a psychometric scale for assessing image quality for chest radiographs