4,523 research outputs found

    Utilizing the Alarm Taxonomy and Classification System (ATACS) to Redesign Landing Gear Warnings

    Get PDF
    Alarms have been in use for many decades, yet there still needs to be more clarity about what makes a good alarm. Vendors and government agencies have developed several useful handbooks describing the Do’s and Don’ts of effective alarm design; however, to date, we cannot find a comprehensive quantitative taxonomy or classification system that allows researchers to easily score and rank various alarm designs in any field—while using a common language that users, engineers, designers, and human factors professionals can understand. The Alarm Taxonomy and Classification System (ATACS) fills this gap in the literature by breaking alarms down into categorical characteristics, providing a quantitative methodology for scoring each characteristic, and outlining a process by which users, vendors, and human factors professionals can agree on the efficacy of the alarm in question. We discuss this process in detail and show how this system was used to improve landing gear warnings

    Functioning and Vision-Related Quality of Life in Severe Peripheral Field Loss due to Retinitis Pigmentosa: A Qualitative Study

    Get PDF
    Vision impairment and blindness are associated with disability and decreased social participation and independence. While vision rehabilitation may improve patients’ functional abilities, there is scarce data regarding the effectiveness of rehabilitation for patients with severe peripheral field loss (PFL). In order to evaluate rehabilitation strategies for individuals with severe PFL, a valid and reliable instrument to measure vision-dependent functioning and vision-related quality of life is needed. Accordingly, this qualitative study was the first phase in developing a patient-reported outcome (PRO) measure tailored to this population. Individuals with retinitis pigmentosa (RP) were recruited from the Kellogg Eye Center and the Association for the Blind and Visually Impaired. The study sample included 17 participants (53% female, mean age 48); median presenting visual acuity and Pelli-Robson contrast sensitivity were 20/40 and 1.2 log contrast sensitivity, respectively. The maximum horizontal extent of the Goldmann visual field was 11° in the better-seeing eye. Study participants completed a semi-structured qualitative interview, and two quality of life questionnaires. Interviews were recorded, transcribed and coded by two independent coders. Thematic analysis of the interview codes identified six vision-related quality of life themes across all RP participants: activity limitations, driving, emotional well-being, reading, mobility and social function. These themes will serve in the development of a PRO specific to severe PFL, which will facilitate evaluation and eventual evolution of low vision rehabilitation for patients with severe PFL

    RNR1, a 3′–5′ exoribonuclease belonging to the RNR superfamily, catalyzes 3′ maturation of chloroplast ribosomal RNAs in Arabidopsis thaliana

    Get PDF
    Arabidopsis thaliana chloroplasts contain at least two 3′ to 5′ exoribonucleases, polynucleotide phosphorylase (PNPase) and an RNase R homolog (RNR1). PNPase has been implicated in both mRNA and 23S rRNA 3′ processing. However, the observed maturation defects do not affect chloroplast translation, suggesting that the overall role of PNPase in maturation of chloroplast rRNA is not essential. Here, we show that this role can be largely ascribed to RNR1, for which homozygous mutants germinate only on sucrose-containing media, and have white cotyledons and pale green rosette leaves. Accumulation of chloroplast-encoded mRNAs and tRNAs is unaffected in such mutants, suggesting that RNR1 activity is either unnecessary or redundant for their processing and turnover. However, accumulation of several chloroplast rRNA species is severely affected. High-resolution RNA gel blot analysis, and mapping of 5′ and 3′ ends, revealed that RNR1 is involved in the maturation of 23S, 16S and 5S rRNAs. The 3′ extensions of the accumulating 5S rRNA precursors can be efficiently removed in vitro by purified RNR1, consistent with this view. Our data suggest that decreased accumulation of mature chloroplast ribosomal RNAs leads to a reduction in the number of translating ribosomes, ultimately compromising chloroplast protein abundance and thus plant growth and development

    For wind turbines in complex terrain, the devil is in the detail

    Get PDF
    Abstract The cost of energy produced by onshore wind turbines is among the lowest available; however, onshore wind turbines are often positioned in a complex terrain, where the wind resources and wind conditions are quite uncertain due to the surrounding topography and/or vegetation. In this study, we use a scale model in a three-dimensional wind-testing chamber to show how minor changes in the terrain can result in significant differences in the flow at turbine height. These differences affect not only the power performance but also the life-time and maintenance costs of wind turbines, and hence, the economy and feasibility of wind turbine projects. We find that the mean wind, wind shear and turbulence level are extremely sensitive to the exact details of the terrain: a small modification of the edge of our scale model, results in a reduction of the estimated annual energy production by at least 50% and an increase in the turbulence level by a factor of five in the worst-case scenario with the most unfavorable wind direction. Wind farm developers should be aware that near escarpments destructive flows can occur and their extent is uncertain thus warranting on-site field measurements.</jats:p

    Complete IRAC mapping of the CFHTLS-DEEP, MUSYC AND NMBS-II FIELDS

    Get PDF
    The IRAC mapping of the NMBS-II fields program is an imaging survey at 3.6 and 4.5Ο\mum with the Spitzer Infrared Array Camera (IRAC). The observations cover three Canada-France-Hawaii Telescope Legacy Survey Deep (CFHTLS-D) fields, including one also imaged by AEGIS, and two MUSYC fields. These are then combined with archival data from all previous programs into deep mosaics. The resulting imaging covers a combined area of about 3 deg2deg^2, with at least ∟\sim2 hr integration time for each field. In this work, we present our data reduction techniques and document the resulting coverage maps at 3.6 and 4.5Ο\mum. All of the images are W-registered to the reference image, which is either the z-band stack image of the 25\% best seeing images from the CFHTLS-D for CFHTLS-D1, CFHTLS-D3, and CFHTLS-D4, or the K-band images obtained at the Blanco 4-m telescope at CTIO for MUSYC1030 and MUSYC1255. We make all images and coverage maps described herein publicly available via the Spitzer Science Center.Comment: Accepted in PASP; released IRAC mosaics available upon publication of the pape

    Sensing remote nuclear spins

    Full text link
    Sensing single nuclear spins is a central challenge in magnetic resonance based imaging techniques. Although different methods and especially diamond defect based sensing and imaging techniques in principle have shown sufficient sensitivity, signals from single nuclear spins are usually too weak to be distinguished from background noise. Here, we present the detection and identification of remote single C-13 nuclear spins embedded in nuclear spin baths surrounding a single electron spins of a nitrogen-vacancy centre in diamond. With dynamical decoupling control of the centre electron spin, the weak magnetic field ~10 nT from a single nuclear spin located ~3 nm from the centre with hyperfine coupling as weak as ~500 Hz is amplified and detected. The quantum nature of the coupling is confirmed and precise position and the vector components of the nuclear field are determined. Given the distance over which nuclear magnetic fields can be detected the technique marks a firm step towards imaging, detecting and controlling nuclear spin species external to the diamond sensor
    • …
    corecore