OntoMathPROOntoMath^{PRO} Ontology: A Linked Data Hub for Mathematics

In this paper, we present an ontology of mathematical knowledge concepts that covers a wide range of the fields of mathematics and introduces a balanced representation between comprehensive and sensible models. We demonstrate the applications of this representation in information extraction, semantic search, and education. We argue that the ontology can be a core of future integration of math-aware data sets in the Web of Data and, therefore, provide mappings onto relevant datasets, such as DBpedia and ScienceWISE.Comment: 15 pages, 6 images, 1 table, Knowledge Engineering and the Semantic Web - 5th International Conferenc

Mitral Annular and Coronary Artery Calcification Are Associated with Mortality in HIV-Infected Individuals.

BackgroundHIV infection increases cardiovascular risk. Coronary artery calcification (CAC) and mitral annular calcification (MAC) identify patients at risk for cardiovascular disease (CVD). The purpose of this study was to examine the association between MAC, CAC and mortality in HIV-infected individuals.Methods and resultsWe studied 152 asymptomatic HIV-infected individuals with transthoracic echocardiography (TTE) and computed tomography (CT). MAC was identified on TTE using standardized criteria. Presence of CAC, CAC score and CAC percentiles were determined using the modified Agatston criteria. Mortality data was obtained from the Social Security and National Death Indices (SSDI/NDI). The median age was 49 years; 87% were male. The median duration of HIV was 16 years; 84% took antiretroviral therapy; 64% had an undetectable viral load. CVD risk factors included hypertension (35%), smoking (62%) and dyslipidemia (35%). Twenty-five percent of individuals had MAC, and 42% had CAC. Over a median follow-up of 8 years, 11 subjects died. Subjects with CAC had significantly higher mortality compared to those with MAC only or no MAC. The Harrell's C-statistic of CAC was 0.66 and increased to 0.75 when MAC was added (p = 0.05). MAC, prior CVD, age and HIV viral load were independently associated with higher age- and gender-adjusted CAC percentiles in an adjusted model (p < 0.05 for all).ConclusionIn HIV patients, the presence of MAC, traditional risk factors and HIV viral load were independently associated with CAC. Presence of CAC and MAC may be useful in identifying HIV-infected individuals at higher risk for death

What lies beneath: Hydra provides cnidarian perspectives into the evolution of FGFR docking proteins

Across the Bilateria, FGF/FGFR signaling is critical for normal development, and in both Drosophila and vertebrates, docking proteins are required to connect activated FGFRs with downstream pathways. While vertebrates use Frs2 to dock FGFR to the RAS/MAPK or PI3K pathways, the unrelated protein, downstream of FGFR (Dof/stumps/heartbroken), fulfills the corresponding function in Drosophila. To better understand the evolution of the signaling pathway downstream of FGFR, the available sequence databases were screened to identify Frs2, Dof, and other key pathway components in phyla that diverged early in animal evolution. While Frs2 homologues were detected only in members of the Bilateria, canonical Dof sequences (containing Dof, ankyrin, and SH2/SH3 domains) were present in cnidarians as well as bilaterians (but not in other animals or holozoans), correlating with the appearance of FGFR. Although these data suggested that Dof coupling might be ancestral, gene expression analysis in the cnidarian Hydra revealed that Dof is not upregulated in the zone of strong FGFRa and FGFRb expression at the bud base, where FGFR signaling controls detachment. In contrast, transcripts encoding other, known elements of FGFR signaling in Bilateria, namely the FGFR adaptors Grb2 and Crkl, which are acting downstream of Dof (and Frs2), as well as the guanyl nucleotide exchange factor Sos, and the tyrosine phosphatase Csw/Shp2, were strongly upregulated at the bud base. Our expression analysis, thus, identified transcriptional upregulation of known elements of FGFR signaling at the Hydra bud base indicating a highly conserved toolkit. Lack of transcriptional Dof upregulation raises the interesting question, whether Hydra FGFR signaling requires either of the docking proteins known from Bilateria

How Many Topics? Stability Analysis for Topic Models

Topic modeling refers to the task of discovering the underlying thematic structure in a text corpus, where the output is commonly presented as a report of the top terms appearing in each topic. Despite the diversity of topic modeling algorithms that have been proposed, a common challenge in successfully applying these techniques is the selection of an appropriate number of topics for a given corpus. Choosing too few topics will produce results that are overly broad, while choosing too many will result in the "over-clustering" of a corpus into many small, highly-similar topics. In this paper, we propose a term-centric stability analysis strategy to address this issue, the idea being that a model with an appropriate number of topics will be more robust to perturbations in the data. Using a topic modeling approach based on matrix factorization, evaluations performed on a range of corpora show that this strategy can successfully guide the model selection process.Comment: Improve readability of plots. Add minor clarification

Vancomycin-bearing Synthetic Bone Graft Delivers rhBMP-2 and Promotes Healing of Critical Rat Femoral Segmental Defects

For graft-assisted repair of large volumetric bone loss resulting from traumatic orthopedic injuries, strategies that simultaneously promote osteointegration/graft healing and mitigate risks for infections are highly desired. Previously, we developed a poly(2-hydroxyethyl methacrylate)-nanocrystalline hydroxyapatite (pHEMA-nHA) composite as a synthetic bone graft. The composite, when loaded with a single dose of 400-ng rhBMP-2/7 and press-fit into a 5-mm rat femoral segmental defect, led to bony callus fully bridging over the defect and substantial restoration of the torsional rigidity by 12 weeks. More recently, we showed that 4.8 wt% vancomycin can be encapsulated within the composite without compromising the structural and mechanical integrity. Additionally, FDA-approved rhBMP-2 can be absorbed onto the graft and both the vancomycin and rhBMP-2 can be released in a localized and sustained manner. Here we examine the efficacy of pHEMA-nHA-vancomycin grafts pre-absorbed with rhBMP-2 in repairing 5-mm rat femoral segmental defects, and determine if vancomycin hinders the repair. pHEMA-nHA-vancomycin or pHEMA-nHA with/without 3-µg rhBMP-2 were press-fit in 5-mm femoral defects in male rats. Histology, microcomputed tomography, and torsion testing were performed on 12-week explants to evaluate the extent and quality of repair. Partial bridging of the defect with bony callus by 12 weeks was observed with pHEMA-nHA-vancomycin without rhBMP-2 while full bridging with substantially mineralized callus and partial restoration of torsional strength was achieved with 3-µg rhBMP-2. The presence of vancomycin did not significantly compromise graft healing. The pHEMA-nHA-vancomycin graft, with the ability to deliver safe doses of osteogenic recombinant proteins and to simultaneously release the encapsulated antibiotics in a sustained manner holds promise in improving the clinical outcome of graft-assisted repair of traumatic bone injuries

Post-Mortem Cardiac Device Retrieval for Re-Use in Third World Nations: Views of the General Public & Patient Population

http://deepblue.lib.umich.edu/bitstream/2027.42/109410/1/postmortemgeneral.pdf61Description of postmortemgeneral.pdf : Presentatio

Profile instabilities of the millisecond pulsar PSR J1022+1001

We present evidence that the integrated profiles of some millisecond pulsars exhibit severe changes that are inconsistent with the moding phenomenon as known from slowly rotating pulsars. We study these profile instabilities in particular for PSR J1022+1001 and show that they occur smoothly, exhibiting longer time constants than those associated with moding. In addition, the profile changes of this pulsar seem to be associated with a relatively narrow-band variation of the pulse shape. Only parts of the integrated profile participate in this process which suggests that the origin of this phenomenon is intrinsic to the pulsar magnetosphere and unrelated to the interstellar medium. A polarization study rules out profile changes due to geometrical effects produced by any sort of precession. However, changes are observed in the circularly polarized radiation component. In total we identify four recycled pulsars which also exhibit instabilities in the total power or polarization profiles due to an unknown phenomenon (PSRs J1022+1001, J1730-2304, B1821-24, J2145-0750). The consequences for high precision pulsar timing are discussed in view of the standard assumption that the integrated profiles of millisecond pulsars are stable. As a result we present a new method to determine pulse times-of-arrival that involves an adjustment of relative component amplitudes of the template profile. Applying this method to PSR J1022+1001, we obtain an improved timing solution with a proper motion measurement of -17 \pm 2 mas/yr in ecliptic longitude. Assuming a distance to the pulsar as inferred from the dispersion measure this corresponds to an one-dimensional space velocity of 50 km/s.Comment: 29 pages, 12 figures, accepted for publication in Ap

Spectral properties of a narrow-band Anderson model

We consider single-particle spectra of a symmetric narrow-band Anderson impurity model, where the host bandwidth $D$ is small compared to the hybridization strength $\Delta_{0}$. Simple 2nd order perturbation theory (2PT) in $U$ is found to produce a rich spectral structure, that leads to rather good agreement with extant Lanczos results and offers a transparent picture of the underlying physics. It also leads naturally to two distinct regimes of spectral behaviour, $\Delta_{0}Z/D\gg 1$ and $\ll 1$ (with $Z$ the quasi-particle weight), whose existence and essential characteristics are discussed and shown to be independent of 2PT itself. The self-energy $\Sigma_{i\omega}$ is also examined beyond the confines of PT. It is argued that on frequency scales of order $\omega\sim\sqrt{Delta_{0}D}$, the self-energy in {\em strong} coupling is given precisely by the 2PT result, and we point out that the resultant poles in $\Sigma_{i\omega}$ connect continuously to that characteristic of the atomic limit. This in turn offers a natural rationale for the known inability of the skeleton expansion to capture such behaviour, and points to the intrinsic dangers of partial infinite-order summations that are based on PT in $U$.Comment: 10 pages, 2 Postscript figures, uses RevTex 3.1; accepted for publication in Phys. Rev. B1

Does Functional Gain and Pain Relief After TKR and THR Differ by Patient Obese Status?

Introduction: Obesity is an important predictor of functional status and pain after total knee (TKR) and total hip (THR) replacement. However, variations in pre-post TKR and THR changes in function and pain by obesity status remain to be examined. Material & Methods: Pre- and 6 month post surgery data were collected on 2,964 primary TKR and 2,040 primary THR patients between 5/2011 and 3/2013. Data included demographics, comorbidities, operative joint pain severity based on the Knee Injury or Hip Disability and Osteoarthritis Outcome Score (KOOS/HOOS), WOMAC pain (higher is better), physical function (SF-36 PCS, higher is better), mental health (SF-36 MCS), and musculoskeletal burden of illness. Pre-post changes in PCS and pain were analyzed using descriptive statistics. Results: TKR patients were average 67 years, 61% women, 93% whites, 13% under or normal weight, 33% overweight, 29% obese, 15% severely obese, 9% morbidly obese. Greater level of obesity was associated with lower PCS at baseline and 6 month, lower pain scores at baseline but larger improvement post-op. Pre to-6 month PCS did not differ by obesity status. At 6 months morbidly obese patients had slightly lower/worse pain score. THR patients were average 65 years, 62% women, 95% whites, 27% under/normal weight, 38% overweight, 23% obese, 9% severely obese, 4% morbidly obese. Greater level of obesity was associated with lower PCS at baseline and 6 month, poorer baseline pain score but larger improvement post-op. Mean changes in pre-to-6 month PCS did not differ by obesity status. Conclusion: At 6 months after TKR, severely obese patients (BMI\u3e35) reported improvements in both pain and function equal to or greater than patients with BMI35 had lower mean functional gain than those with BM

Single-inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol and umeclidinium/vilanterol in patients with COPD:results on cardiovascular safety from the IMPACT trial

BACKGROUND: This analysis of the IMPACT study assessed the cardiovascular (CV) safety of single-inhaler triple therapy with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus FF/VI and UMEC/VI dual therapy. METHODS: IMPACT was a 52-week, randomized, double-blind, multicenter Phase III study comparing the efficacy and safety of FF/UMEC/VI 100/62.5/25 mcg with FF/VI 100/25 mcg or UMEC/VI 62.5/25 mcg in patients ≥40 years of age with symptomatic chronic obstructive pulmonary disease (COPD) and ≥1 moderate/severe exacerbation in the previous year. The inclusion criteria for the study were intentionally designed to permit the enrollment of patients with significant concurrent CV disease/risk. CV safety assessments included proportion of patients with and exposure-adjusted rates of on-treatment CV adverse events of special interest (CVAESI) and major adverse cardiac events (MACE), as well as time-to-first (TTF) CVAESI, and TTF CVAESI resulting in hospitalization/prolonged hospitalization or death. RESULTS: Baseline CV risk factors were similar across treatment groups. Overall, 68% of patients (n = 7012) had ≥1 CV risk factor and 40% (n = 4127) had ≥2. At baseline, 29% of patients reported a current/past cardiac disorder and 58% reported a current/past vascular disorder. The proportion of patients with on-treatment CVAESI was 11% for both FF/UMEC/VI and UMEC/VI, and 10% for FF/VI. There was no statistical difference for FF/UMEC/VI versus FF/VI or UMEC/VI in TTF CVAESI (hazard ratio [HR]: 0.98, 95% confidence interval [CI]: 0.85, 1.11; p = 0.711 and HR: 0.92, 95% CI: 0.78, 1.08; p = 0.317, respectively) nor TTF CVAESI leading to hospitalization/prolonged hospitalization or death (HR: 1.19, 95% CI: 0.93, 1.51; p = 0.167 and HR: 0.96, 95% CI: 0.72, 1.27; p = 0.760, respectively). On-treatment MACE occurred in ≤3% of patients across treatment groups, with similar prevalence and rates between treatments. CONCLUSIONS: In a symptomatic COPD population with a history of exacerbations and a high rate of CV disease/risk, the proportion of patients with CVAESI and MACE was 10-11% and 1-3%, respectively, across treatment arms, and the risk of CVAESI was low and similar across treatment arms. There was no statistically significant increased CV risk associated with the use of FF/UMEC/VI versus FF/VI or UMEC/VI, and UMEC/VI versus FF/VI. TRIAL REGISTRATION: NCT02164513 (GSK study number CTT116855)