Can Parents Create Alcoholics?

Background: Research has shown a definitive genetic component to alcoholism, with children of alcoholic parents being much more likely to become alcoholics themselves when compared to children of non-alcoholics. Just because alcoholism runs in an individual\u27s family does not guarantee that said individual will become an alcoholic. This paper tries to discern if the way a parent raises their child can have an effect on the likelihood of the child being an alcoholic later in life. Results: A review of the literature suggests that there may be a correlation between a how a child is raised and the likelihood of the child becoming an alcoholic. Research shows authoritative parents to raise children who are better able to self-regulate and have higher self-esteem, both qualities that deter alcoholic tendencies. Research also shows that authoritative and neglectful parents raise children who have higher incidences of depression and low self-esteem, both potential risk factors for alcoholism. Conclusion: Reviewing the literature provides a theoretical framework for a study to be done to try and more fully and completely explore the relationship between parenting styles and alcoholism

Localizing coalescing massive black hole binaries with gravitational waves

Massive black hole binary coalescences are prime targets for space-based gravitational wave (GW) observatories such as {\it LISA}. GW measurements can localize the position of a coalescing binary on the sky to an ellipse with a major axis of a few tens of arcminutes to a few degrees, depending on source redshift, and a minor axis which is $2 - 4$ times smaller. Neglecting weak gravitational lensing, the GWs would also determine the source's luminosity distance to better than percent accuracy for close sources, degrading to several percent for more distant sources. Weak lensing cannot, in fact, be neglected and is expected to limit the accuracy with which distances can be fixed to errors no less than a few percent. Assuming a well-measured cosmology, the source's redshift could be inferred with similar accuracy. GWs alone can thus pinpoint a binary to a three-dimensional ``pixel'' which can help guide searches for the hosts of these events. We examine the time evolution of this pixel, studying it at merger and at several intervals before merger. One day before merger, the major axis of the error ellipse is typically larger than its final value by a factor of $\sim 1.5-6$. The minor axis is larger by a factor of $\sim 2-9$, and, neglecting lensing, the error in the luminosity distance is larger by a factor of $\sim 1.5-7$. This large change over a short period of time is due to spin-induced precession, which is strongest in the final days before merger. The evolution is slower as we go back further in time. For $z = 1$, we find that GWs will localize a coalescing binary to within $\sim 10\ \mathrm{deg}^2$ as early as a month prior to merger and determine distance (and hence redshift) to several percent.Comment: 30 pages, 10 figures, 5 tables. Version published in Ap

Snow Cover in Alaska: Comprehensive Review

This report presents the results of a statistical analysis of snow cover in Alaska using historical data acquired from the Global Historical Climate Network. Measurements of snow depth and snow water equivalence were collected for Alaska stations between 1950 and 2017. Data cleaning and a distribution analysis were completed for all stations. Finally regression equations were developed to estimate snow water equivalence using recorded snow depth data from Alaska stations. The project is partially supported by ConocoPhillips Arctic Science and Engineering Foundation, UAA, and the Structural Engineers Association of Alaska (SEAAK).University of Alaska Anchorage ConocoPhillips Arctic Science and Engineering Foundation Structural Engineers Association of AlaskaAbstract / Introduction / Methodology / Discussion / Conclusion / References / Appendix 1 Predicted 50-year WESD Stations's snow laods / Appendix 2 Calcuated 50-Year SNWD Station's snow loads / Appendix 3 Distribution Assignment for WESD and SNWD Stations / Appendix 4 Station Plot

Predicted protein-protein interactions in the moss Physcomitrella patens: a new bioinformatic resource.

BACKGROUND: Physcomitrella patens, a haploid dominant plant, is fast becoming a useful molecular genetics and bioinformatics tool due to its key phylogenetic position as a bryophyte in the post-genomic era. Genome sequences from select reference species were compared bioinformatically to Physcomitrella patens using reciprocal blasts with the InParanoid software package. A reference protein interaction database assembled using MySQL by compiling BioGrid, BIND, DIP, and Intact databases was queried for moss orthologs existing for both interacting partners. This method has been used to successfully predict interactions for a number of angiosperm plants. RESULTS: The first predicted protein-protein interactome for a bryophyte based on the interolog method contains 67,740 unique interactions from 5,695 different Physcomitrella patens proteins. Most conserved interactions among proteins were those associated with metabolic processes. Over-represented Gene Ontology categories are reported here. CONCLUSION: Addition of moss, a plant representative 200 million years diverged from angiosperms to interactomic research greatly expands the possibility of conducting comparative analyses giving tremendous insight into network evolution of land plants. This work helps demonstrate the utility of guilt-by-association models for predicting protein interactions, providing provisional roadmaps that can be explored using experimental approaches. Included with this dataset is a method for characterizing subnetworks and investigating specific processes, such as the Calvin-Benson-Bassham cycle

Spectral variations of the X-ray binary pulsar LMC X-4 during its long period intensity variation and a comparison with Her X-1

We present spectral variations of the binary X-ray pulsar LMC X-4 using the RXTE/PCA observations at different phases of its 30.5 day long super-orbital period. Only out of eclipse data were used for this study. During the high state of the super-orbital period of LMC X-4, the spectrum is well described by a high energy cut-off power-law with a photon index in the range of 0.7-1.0 and an iron emission line. In the low state, the spectrum is found to be flatter with power-law photon index in the range 0.5-0.7. A direct correlation is detected between the continuum flux in 7-25 keV energy band and the iron emission line flux. The equivalent width of the iron emission line is found to be highly variable during low intensity state, whereas it remains almost constant during the high intensity state of the super-orbital period. It is observed that the spectral variations in LMC X-4 are similar to those of Her X-1 (using RXTE/PCA data). These results suggest that the geometry of the region where the iron line is produced and its visibility with respect to the phase of the super-orbital period is similar in LMC X-4 and Her X-1. A remarkable difference between these two systems is a highly variable absorption column density with phase of the super-orbital period that is observed in Her X-1 but not in LMC X-4.Comment: 7 pages, 5 figures, Accepted for publication in Astronomy and Astrophysic

Clinical implications for patients treated inappropriately for community-acquired pneumonia in the emergency department

BACKGROUND: Community-acquired pneumonia (CAP) is one of the most common infections presenting to the emergency department (ED). Increasingly, antibiotic resistant bacteria have been identified as causative pathogens in patients treated for CAP, especially in patients with healthcare exposure risk factors. METHODS: We retrospectively identified adult subjects treated for CAP in the ED requiring hospital admission (January 2003-December 2011). Inappropriate antibiotic treatment, defined as an antibiotic regimen that lacked in vitro activity against the isolated pathogen, served as the primary end point. Information regarding demographics, severity of illness, comorbidities, and antibiotic treatment was recorded. Logistic regression was used to determine factors independently associated with inappropriate treatment. RESULTS: The initial cohort included 259 patients, 72 (27.8%) receiving inappropriate antibiotic treatment. There was no difference in hospital mortality between patients receiving inappropriate and appropriate treatment (8.3% vs. 7.0%; p = 0.702). Hospital length of stay (10.3 ± 12.0 days vs. 7.0 ± 8.9 days; p = 0.017) and 30-day readmission (23.6% vs. 12.3%; p = 0.024) were greater among patients receiving inappropriate treatment. Three variables were independently associated with inappropriate treatment: admission from long-term care (AOR, 9.05; 95% CI, 3.93-20.84), antibiotic exposure in the previous 30 days (AOR, 1.85; 95% CI, 1.35-2.52), and chronic obstructive pulmonary disease (AOR, 2.05; 95% CI, 1.52-2.78). CONCLUSION: Inappropriate antibiotic treatment of presumed CAP in the ED negatively impacts patient outcome and readmission rate. Knowledge of risk factors associated with inappropriate antibiotic treatment of presumed CAP could advance the management of patients with pneumonia presenting to the ED and potentially improve patient outcomes

The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer.

A better understanding of the dynamics of molecular changes occurring during the early stages of oral tumorigenesis may help refine prevention and treatment strategies. We generated genome-wide expression profiles of microdissected normal mucosa, hyperplasia, dysplasia and tumors derived from the 4-NQO mouse model of oral tumorigenesis. Genes differentially expressed between tumor and normal mucosa defined the "tumor gene set" (TGS), including 4 non-overlapping gene subsets that characterize the dynamics of gene expression changes through different stages of disease progression. The majority of gene expression changes occurred early or progressively. The relevance of these mouse gene sets to human disease was tested in multiple datasets including the TCGA and the Genomics of Drug Sensitivity in Cancer project. The TGS was able to discriminate oral squamous cell carcinoma (OSCC) from normal oral mucosa in 3 independent datasets. The OSCC samples enriched in the mouse TGS displayed high frequency of CASP8 mutations, 11q13.3 amplifications and low frequency of PIK3CA mutations. Early changes observed in the 4-NQO model were associated with a trend toward a shorter oral cancer-free survival in patients with oral preneoplasia that was not seen in multivariate analysis. Progressive changes observed in the 4-NQO model were associated with an increased sensitivity to 4 different MEK inhibitors in a panel of 51 squamous cell carcinoma cell lines of the areodigestive tract. In conclusion, the dynamics of molecular changes in the 4-NQO model reveal that MEK inhibition may be relevant to prevention and treatment of a specific molecularly-defined subgroup of OSCC

Two-dimensional Hubbard-Holstein bipolaron

We present a diagrammatic Monte Carlo study of the properties of the Hubbard-Holstein bipolaron on a two-dimensional square lattice. With a small Coulomb repulsion, U, and with increasing electron-phonon interaction, and when reaching a value about two times smaller than the one corresponding to the transition of light polaron to heavy polaron, the system suffers a sharp transition from a state formed by two weakly bound light polarons to a heavy, strongly bound on-site bipolaron. Aside from this rather conventional bipolaron a new bipolaron state is found for large U at intermediate and large electron-phonon coupling, corresponding to two polarons bound on nearest-neighbor sites. We discuss both the properties of the different bipolaron states and the transition from one state to another. We present a phase diagram in parameter space defined by the electron-phonon coupling and U. Our numerical method does not use any artificial approximation and can be easily modified to other bipolaron models with longer range electron-phonon and/or electron-electron interaction.Comment: 14 pages, 12 figure