1,279 research outputs found
Genome characterization and population genetic structure of the zoonotic pathogen, streptococcus canis
Background - Streptococcus canis is an important opportunistic pathogen of dogs and cats that can also infect a wide range of additional mammals including cows where it can cause mastitis. It is also an emerging human pathogen.
Results - Here we provide characterization of the first genome sequence for this species, strain FSL S3-227 (milk isolate from a cow with an intra-mammary infection). A diverse array of putative virulence factors was encoded by the S. canis FSL S3-227 genome. Approximately 75% of these gene sequences were homologous to known Streptococcal virulence factors involved in invasion, evasion, and colonization. Present in the genome are multiple potentially mobile genetic elements (MGEs) [plasmid, phage, integrative conjugative element (ICE)] and comparison to other species provided convincing evidence for lateral gene transfer (LGT) between S. canis and two additional bovine mastitis causing pathogens (Streptococcus agalactiae, and Streptococcus dysgalactiae subsp. dysgalactiae), with this transfer possibly contributing to host adaptation. Population structure among isolates obtained from Europe and USA [bovine = 56, canine = 26, and feline = 1] was explored. Ribotyping of all isolates and multi locus sequence typing (MLST) of a subset of the isolates (n = 45) detected significant differentiation between bovine and canine isolates (Fisher exact test: P = 0.0000 [ribotypes], P = 0.0030 [sequence types]), suggesting possible host adaptation of some genotypes. Concurrently, the ancestral clonal complex (54% of isolates) occurred in many tissue types, all hosts, and all geographic locations suggesting the possibility of a wide and diverse niche.
Conclusion - This study provides evidence highlighting the importance of LGT in the evolution of the bacteria S. canis, specifically, its possible role in host adaptation and acquisition of virulence factors. Furthermore, recent LGT detected between S. canis and human bacteria (Streptococcus urinalis) is cause for concern, as it highlights the possibility for continued acquisition of human virulence factors for this emerging zoonotic pathogen
Current-Induced Effects in Nanoscale Conductors
We present an overview of current-induced effects in nanoscale conductors
with emphasis on their description at the atomic level. In particular, we
discuss steady-state current fluctuations, current-induced forces, inelastic
scattering and local heating. All of these properties are calculated in terms
of single-particle wavefunctions computed using a scattering approach within
the static density-functional theory of many-electron systems. Examples of
current-induced effects in atomic and molecular wires will be given and
comparison with experimental results will be provided when available.Comment: revtex, 10 pages, 8 figure
High Spin Glueballs from the Lattice
We discuss the principles underlying higher spin glueball calculations on the
lattice. For that purpose, we develop numerical techniques to rotate Wilson
loops by arbitrary angles in lattice gauge theories close to the continuum. As
a first application, we compute the glueball spectrum of the SU(2) gauge theory
in 2+1 dimensions for both parities and for spins ranging from 0 up to 4
inclusive. We measure glueball angular wave functions directly, decomposing
them in Fourier modes and extrapolating the Fourier coefficients to the
continuum. This allows a reliable labelling of the continuum states and gives
insight into the way rotation symmetry is recovered. As one of our results, we
demonstrate that the D=2+1 SU(2) glueball conventionally labelled as J^P = 0^-
is in fact 4^- and that the lightest ``J=1'' state has, in fact, spin 3.Comment: Minor changes in the text; the spin 4 glueball mass is taken further
out in Euclidean time at higher beta values. 41 pages, 20 figure
Noise-free scattering of the quantized electromagnetic field from a dispersive linear dielectric
We study the scattering of the quantized electromagnetic field from a linear,
dispersive dielectric using the scattering formalism for quantum fields. The
medium is modeled as a collection of harmonic oscillators with a number of
distinct resonance frequencies. This model corresponds to the Sellmeir
expansion, which is widely used to describe experimental data for real
dispersive media. The integral equation for the interpolating field in terms of
the in field is solved and the solution used to find the out field. The
relation between the in and out creation and annihilation operators is found
which allows one to calculate the S-matrix for this system. In this model, we
find that there are absorption bands, but the input-output relations are
completely unitary. No additional quantum noise terms are required.Comment: Revtex, submitted to Physical Review
Трехкоординатный пьезокерамический сканер на биморфных пьезо-элементах для зондового наномикроскопа
Предложена и исследована конструкция пьезокерамического сканера для наномикроскопов на основе диморфных пьезоэлементов. Построена и исследована модель сканера при помощи программы MicroCap 7.0
Electronic correlation in the infrared optical properties of the quasi two dimensional -type BEDT-TTF dimer system
The polarized optical reflectance spectra of the quasi two dimensional
organic correlated electron system -(BEDT-TTF)Cu[N(CN)],
Br and Cl are measured in the infrared region. The former shows the
superconductivity at 11.6 K and the latter does the
antiferromagnetic insulator transition at 28 K. Both the
specific molecular vibration mode of the BEDT-TTF molecule and
the optical conductivity hump in the mid-infrared region change correlatively
at 38 K of -(BEDT-TTF)Cu[N(CN)]Br, although
no indication of but the insulating behaviour below 50-60 K are found in -(BEDT-TTF)Cu[N(CN)]Cl. The
results suggest that the electron-molecular vibration coupling on the
mode becomes weak due to the enhancement of the itinerant
nature of the carriers on the dimer of the BEDT-TTF molecules below ,
while it does strong below because of the localized carriers on
the dimer. These changes are in agreement with the reduction and the
enhancement of the mid-infrared conductivity hump below and , respectively, which originates from the transitions between the upper
and lower Mott-Hubbard bands. The present observations demonstrate that two
different metallic states of -(BEDT-TTF)Cu[N(CN)]Br are
regarded as {\it a correlated good metal} below including the
superconducting state and {\it a half filling bad metal} above . In
contrast the insulating state of -(BEDT-TTF)Cu[N(CN)]Cl
below is the Mott insulator.Comment: 8 pages, 7 figure
Electrostatic potential profiles of molecular conductors
The electrostatic potential across a short ballistic molecular conductor
depends sensitively on the geometry of its environment, and can affect its
conduction significantly by influencing its energy levels and wave functions.
We illustrate some of the issues involved by evaluating the potential profiles
for a conducting gold wire and an aromatic phenyl dithiol molecule in various
geometries. The potential profile is obtained by solving Poisson's equation
with boundary conditions set by the contact electrochemical potentials and
coupling the result self-consistently with a nonequilibrium Green's function
(NEGF) formulation of transport. The overall shape of the potential profile
(ramp vs. flat) depends on the feasibility of transverse screening of electric
fields. Accordingly, the screening is better for a thick wire, a multiwalled
nanotube or a close-packed self-assembled monolayer (SAM), in comparison to a
thin wire, a single-walled nanotube or an isolated molecular conductor. The
electrostatic potential further governs the alignment or misalignment of
intramolecular levels, which can strongly influence the molecular I-V
characteristic. An external gate voltage can modify the overall potential
profile, changing the current-voltage (I-V) characteristic from a resonant
conducting to a saturating one. The degree of saturation and gate modulation
depends on the metal-induced-gap states (MIGS) and on the electrostatic gate
control parameter set by the ratio of the gate oxide thickness to the channel
length.Comment: to be published in Phys. Rev. B 69, No.3, 0353XX (2004
Studying Kaon-pion S-wave scattering in K-matrix formalism
We generalize our previous work on \pi\pi scattering to K\pi scattering, and
re-analyze the experiment data of K\pi scattering below 1.6 GeV. Without any
free parameter, we explain K\pi I=3/2 S-wave phase shift very well by using
t-channel rho and u-channel K^* meson exchange. With the t-channel and
u-channel meson exchange fixed as the background term, we fit the K\pi I=1/2
S-wave data of the LASS experiment quite well by introducing one or two
s-channel resonances. It is found that there is only one s-channel resonance
between K\pi threshold and 1.6 GeV, i.e., K_0^*(1430) with a mass around
1438~1486 MeV and a width about 346 MeV, while the t-channel rho exchange gives
a pole at (450-480i) MeV for the amplitude.Comment: REVTeX4 file, 11 pages and 3 figure
A high resolution imaging detector for TeV gamma-ray astronomy
Details are presented of an atmospheric Cherenkov telescope for use in very high energy gamma-ray astronomy which consists of a cluster of 109 close-packed photomultiplier tubes at the focus of a 10 meter optical reflector. The images of the Cherenkov flashes generated both by gamma-ray and charged cosmic-ray events are digitized and recorded. Subsequent off-line analysis of the images improves the significance of the signal to noise ratio by a factor of 10 compared with non-imaging techniques
Lattice dynamics effects on small polaron properties
This study details the conditions under which strong-coupling perturbation
theory can be applied to the molecular crystal model, a fundamental theoretical
tool for analysis of the polaron properties. I show that lattice dimensionality
and intermolecular forces play a key role in imposing constraints on the
applicability of the perturbative approach. The polaron effective mass has been
computed in different regimes ranging from the fully antiadiabatic to the fully
adiabatic. The polaron masses become essentially dimension independent for
sufficiently strong intermolecular coupling strengths and converge to much
lower values than those tradition-ally obtained in small-polaron theory. I find
evidence for a self-trapping transition in a moderately adiabatic regime at an
electron-phonon coupling value of .3. Our results point to a substantial
independence of the self-trapping event on dimensionality.Comment: 8 pages, 5 figure
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