Determining the motion of the solar system relative to the cosmic microwave background using type Ia supernovae

We estimate the solar system motion relative to the cosmic microwave background using type Ia supernovae (SNe) measurements. We take into account the correlations in the error bars of the SNe measurements arising from correlated peculiar velocities. Without accounting for correlations in the peculiar velocities, the SNe data we use appear to detect the peculiar velocity of the solar system at about the 3.5 sigma level. However, when the correlations are correctly accounted for, the SNe data only detects the solar system peculiar velocity at about the 2.5 sigma level. We forecast that the solar system peculiar velocity will be detected at the 9 sigma level by GAIA and the 11 sigma level by the LSST. For these surveys we find the correlations are much less important as most of the signal comes from higher redshifts where the number density of SNe is insufficient for the correlations to be important.Comment: 6 pages, 6 figures; fixed a typo; matches version to appear in MNRA

From the open road to the high seas? Piracy, damnation and resistance in academic consumption of publishing

Armin Beverungen conducts research on how universities retain their charitable status in a market environment, and on the teaching of ethics in business schools. Steffen Böhm has a particular interest in the economics and management of sustainability. He has also founded an open access journal and an open access press, MayFlyBooks. Christopher Land works on artists and the management of their creativity

Genome-scale resources for Thermoanaerobacterium saccharolyticum

Background Thermoanaerobacterium saccharolyticum is a hemicellulose-degrading thermophilic anaerobe that was previously engineered to produce ethanol at high yield. A major project was undertaken to develop this organism into an industrial biocatalyst, but the lack of genome information and resources were recognized early on as a key limitation. Results Here we present a set of genome-scale resources to enable the systems level investigation and development of this potentially important industrial organism. Resources include a complete genome sequence for strain JW/SL-YS485, a genome-scale reconstruction of metabolism, tiled microarray data showing transcription units, mRNA expression data from 71 different growth conditions or timepoints and GC/MS-based metabolite analysis data from 42 different conditions or timepoints. Growth conditions include hemicellulose hydrolysate, the inhibitors HMF, furfural, diamide, and ethanol, as well as high levels of cellulose, xylose, cellobiose or maltodextrin. The genome consists of a 2.7 Mbp chromosome and a 110 Kbp megaplasmid. An active prophage was also detected, and the expression levels of CRISPR genes were observed to increase in association with those of the phage. Hemicellulose hydrolysate elicited a response of carbohydrate transport and catabolism genes, as well as poorly characterized genes suggesting a redox challenge. In some conditions, a time series of combined transcription and metabolite measurements were made to allow careful study of microbial physiology under process conditions. As a demonstration of the potential utility of the metabolic reconstruction, the OptKnock algorithm was used to predict a set of gene knockouts that maximize growth-coupled ethanol production. The predictions validated intuitive strain designs and matched previous experimental results. Conclusion These data will be a useful asset for efforts to develop T. saccharolyticum for efficient industrial production of biofuels. The resources presented herein may also be useful on a comparative basis for development of other lignocellulose degrading microbes, such as Clostridium thermocellum. Electronic supplementary material The online version of this article (doi:10.1186/s12918-015-0159-x) contains supplementary material, which is available to authorized users

Jet-induced cratering of a granular surface with application to lunar spaceports

The erosion of lunar soil by rocket exhaust plumes is investigated experimentally. This has identified the diffusion-driven flow in the bulk of the sand as an important but previously unrecognized mechanism for erosion dynamics. It has also shown that slow regime cratering is governed by the recirculation of sand in the widening geometry of the crater. Scaling relationships and erosion mechanisms have been characterized in detail for the slow regime. The diffusion-driven flow occurs in both slow and fast regime cratering. Because diffusion-driven flow had been omitted from the lunar erosion theory and from the pressure cratering theory of the Apollo and Viking era, those theories cannot be entirely correct.Comment: 13 pages, link to published version: http://cedb.asce.org/cgi/WWWdisplay.cgi?090000

The Magnitude of Global Marine Species Diversity

Background: The question of how many marine species exist is important because it provides a metric for how much we do and do not know about life in the oceans. We have compiled the first register of the marine species of the world and used this baseline to estimate how many more species, partitioned among all major eukaryotic groups, may be discovered. Results: There are ∼226,000 eukaryotic marine species described. More species were described in the past decade (∼20,000) than in any previous one. The number of authors describing new species has been increasing at a faster rate than the number of new species described in the past six decades. We report that there are ∼170,000 synonyms, that 58,000–72,000 species are collected but not yet described, and that 482,000–741,000 more species have yet to be sampled. Molecular methods may add tens of thousands of cryptic species. Thus, there may be 0.7–1.0 million marine species. Past rates of description of new species indicate there may be 0.5 ± 0.2 million marine species. On average 37% (median 31%) of species in over 100 recent field studies around the world might be new to science. Conclusions: Currently, between one-third and two-thirds of marine species may be undescribed, and previous estimates of there being well over one million marine species appear highly unlikely. More species than ever before are being described annually by an increasing number of authors. If the current trend continues, most species will be discovered this century

Anatomical Specializations for Nocturnality in a Critically Endangered Parrot, the Kakapo (Strigops habroptilus)

The shift from a diurnal to nocturnal lifestyle in vertebrates is generally associated with either enhanced visual sensitivity or a decreased reliance on vision. Within birds, most studies have focused on differences in the visual system across all birds with respect to nocturnality-diurnality. The critically endangered Kakapo (Strigops habroptilus), a parrot endemic to New Zealand, is an example of a species that has evolved a nocturnal lifestyle in an otherwise diurnal lineage, but nothing is known about its' visual system. Here, we provide a detailed morphological analysis of the orbits, brain, eye, and retina of the Kakapo and comparisons with other birds. Morphometric analyses revealed that the Kakapo's orbits are significantly more convergent than other parrots, suggesting an increased binocular overlap in the visual field. The Kakapo exhibits an eye shape that is consistent with other nocturnal birds, including owls and nightjars, but is also within the range of the diurnal parrots. With respect to the brain, the Kakapo has a significantly smaller optic nerve and tectofugal visual pathway. Specifically, the optic tectum, nucleus rotundus and entopallium were significantly reduced in relative size compared to other parrots. There was no apparent reduction to the thalamofugal visual pathway. Finally, the retinal morphology of the Kakapo is similar to that of both diurnal and nocturnal birds, suggesting a retina that is specialised for a crepuscular niche. Overall, this suggests that the Kakapo has enhanced light sensitivity, poor visual acuity and a larger binocular field than other parrots. We conclude that the Kakapo possesses a visual system unlike that of either strictly nocturnal or diurnal birds and therefore does not adhere to the traditional view of the evolution of nocturnality in birds

Stress and breast cancer: from epidemiology to molecular biology

Stress exposure has been proposed to contribute to the etiology of breast cancer. However, the validity of this assertion and the possible mechanisms involved are not well established. Epidemiologic studies differ in their assessment of the relative contribution of stress to breast cancer risk, while physiological studies propose a clear connection but lack the knowledge of intracellular pathways involved. The present review aims to consolidate the findings from different fields of research (including epidemiology, physiology, and molecular biology) in order to present a comprehensive picture of what we know to date about the role of stress in breast cancer development

Modeling International Diffusion: Inferential Benefits and Methodological Challenges, with an Application to International Tax Competition

Although scholars recognize that time-series-cross-section data typically correlate across both time and space, they tend to model temporal dependence directly, often by lags of dependent variables, but to address spatial interdependence solely as a nuisance to be “corrected” by FGLS or to which to be “robust” in standard-error estimation (by PCSE). We explore the inferential benefits and methodological challenges of directly modeling international diffusion, one form of spatial dependence. To this end, we first identify two substantive classes of modern comparative-and-international-political-economy (C&IPE) theoretical models—(context-conditional) open-economy comparative political-economy (CPE) models and international political-economy (IPE) models, which imply diffusion (along with predecessors, closed-economy CPE and orthogonal open-economy CPE)—and then we evaluate the relative performance of three estimators—non-spatial OLS, spatial OLS, and spatial 2SLS—for analyzing empirical models corresponding to these two modern alternative theoretical visions from spatially interdependent data. Finally, we offer a substantive application of the spatial 2SLS approach in what we call a spatial error-correction model of international tax competition.Obwohl Wissenschaftler wissen, dass Zeitreihenquerschnittsdaten sowohl über die Zeit als auch über den Raum korreliert sind, neigen sie dazu, die zeitliche Abhängigkeit direkt zu modellieren, z. B. durch Zeitabstände der abhängigen Variablen. Die räumliche Abhängigkeit jedoch wird als ein Ärgernis angesehen, welches durch FGLS ‚korrigiert’ wird oder ‚robust’ gemacht wird in Standard- Abweichungs-Schätzungen (durch PCSE). Wir untersuchen methodologische Herausforderungen und die Nutzen für Schlussfolgerungen aus einer direkten Modellierung internationaler Diffusion als einer Form der räumlichen Abhängigkeit. Zu diesem Zweck identifizieren wir zuerst zwei inhaltliche Hauptklassen theoretischer Modelle der modernen ‚Vergleichenden und Internationalen Politischen Ökonomie“, nämlich Modelle der (kontextbezogenen) Vergleichenden Politischen Ökonomie Offener Volkwirtschaften und Modelle der Internationalen Politischen Ökonomie. Diese bilden Diffusion ab, ebenso wie die Vorläufermodelle der Vergleichenden Politischen Ökonomie geschlossener Volkswirtschaften und gegensätzlich offener Volkswirtschaften. Zweitens bewerten wir die relative Performanz von drei Schätzern – nicht-räumliche OLS, räumliche OLS und räumliche 2SLS. Schließlich wenden wir den Ansatz des räumlichen 2SLS in einem von uns so genannten ‚Spatial Error Correction’-Modell des internationalen Steuerwettbewerbs an

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery