13,132 research outputs found
Gain functionalization of silica microresonators
Erbium-doped solgel films are applied to the surface of silica microspheres to create low-threshold microcavity lasers. This gain functionalization can be applied by use of a number of different dopants, thereby extending the wavelength range of this class of device. Also, by varying the doping concentration and thickness of the applied solgel layer, one can vary the laser dynamics so that both continuous-wave and pulsating modes of operation are possible
Fiber-coupled erbium microlasers on a chip
An erbium-doped, toroid-shaped microlaser fabricated on a silicon chip is described and characterized. Erbium-doped sol-gel films are applied to the surface of a silica toroidal microresonator to create the microcavity lasers. Highly confined whispering gallery modes make possible single-mode and ultralow threshold microlasers
Search for Higgs Bosons Decay Using Vector Boson Fusion
The sensitivity of the ATLAS experiment to low mass SM Higgs produced via
Vector Boson Fusion mechanism with is invest igated. A cut
based event selection has been chosen to optimize the expected signal
significance with this decay mode. A signal significance of 2. 2 may
be achieved for M_H=130 \gev with 30 fb of accumulated luminosity
Integrated signaling pathway and gene expression regulatory model to dissect dynamics of <em>Escherichia coli </em>challenged mammary epithelial cells
AbstractCells transform external stimuli, through the activation of signaling pathways, which in turn activate gene regulatory networks, in gene expression. As more omics data are generated from experiments, eliciting the integrated relationship between the external stimuli, the signaling process in the cell and the subsequent gene expression is a major challenge in systems biology. The complex system of non-linear dynamic protein interactions in signaling pathways and gene networks regulates gene expression.The complexity and non-linear aspects have resulted in the study of the signaling pathway or the gene network regulation in isolation. However, this limits the analysis of the interaction between the two components and the identification of the source of the mechanism differentiating the gene expression profiles. Here, we present a study of a model of the combined signaling pathway and gene network to highlight the importance of integrated modeling.Based on the experimental findings we developed a compartmental model and conducted several simulation experiments. The model simulates the mRNA expression of three different cytokines (RANTES, IL8 and TNFα) regulated by the transcription factor NFκB in mammary epithelial cells challenged with E. coli. The analysis of the gene network regulation identifies a lack of robustness and therefore sensitivity for the transcription factor regulation. However, analysis of the integrated signaling and gene network regulation model reveals distinctly different underlying mechanisms in the signaling pathway responsible for the variation between the three cytokine's mRNA expression levels. Our key findings reveal the importance of integrating the signaling pathway and gene expression dynamics in modeling. Modeling infers valid research questions which need to be verified experimentally and can assist in the design of future biological experiments
Realistic interpretation of a superposition state does not imply a mixture
Contrary to previous claims, it is shown that, for an ensemble of either
single-particle systems or multi-particle systems, the realistic interpretation
of a superposition state that mathematically describes the ensemble does not
imply that the ensemble is a mixture. Therefore it cannot be argued that the
realistic interpretation is wrong on the basis that some predictions derived
from the mixture are different from the corresponding predictions derived from
the superposition state
Plasmon Injection to Compensate and Control Losses in Negative Index Metamaterials
Metamaterials have introduced a whole new world of unusual materials with
functionalities that cannot be attained in naturally occurring material systems
by mimicking and controlling the natural phenomena at subwavelength scales.
However, the inherent absorption losses pose fundamental challenge to the most
fascinating applications of metamaterials. Based on a novel plasmon injection
(PI or \Pi) scheme, we propose a coherent optical amplification technique to
compensate losses in metamaterials. Although the proof of concept device here
operates under normal incidence only, our proposed scheme can be generalized to
arbitrary form of incident waves. The \Pi-scheme is fundamentally different
than major optical amplification schemes. It does not require gain medium,
interaction with phonons, or any nonlinear medium. The \Pi-scheme allows for
loss-free metamaterials. It is ideally suited for mitigating losses in
metamaterials operating in the visible spectrum and is scalable to other
optical frequencies. These findings open the possibility of reviving the early
dreams of making 'magical' metamaterials from scratch.Comment: Main text, 8 pages with 4 figures; supplemental material, 21 pages
with 21 figure
AMPHIBIAN DISTRIBUTION IN THE GEORGIA SEA ISLANDS: IMPLICATIONS FROM THE PAST AND FOR THE FUTURE
We summarized amphibian distributions for 12 coastal islands in Georgia, USA. Occurrence among islands was correlated with life history traits, habitats, island size, distance to other islands, and island geological age. Species’ distributions were determined from published literature. Island sizes and vegetation types were derived from 2011 Georgia Department of Natural Resources habitat maps, which included both federal and state vegetation classification systems. Species occurring on more islands tended to have greater total reproductive output (i.e., life span >4 years, and annual egg production >1,000 eggs) and adults had tolerance of brackish environs. Larger islands had greater area of freshwater wetlands, predominantly short hydroperiod (<6 months). Species tied to long hydroperiod wetlands (>6 months) were more restricted in their distribution across islands. Overall, larger islands supported more species, but the correlation was weaker for geologically younger Holocene islands (age <11,000 years). While Euclidean distance between islands does not necessarily preclude inter-island dispersal, inhospitable habitat for amphibians (brackish tidal marshes and creeks interspersed with wide rivers) suggests that inter-island dispersal is very limited. The paucity of recent occurrence data for amphibians in this dynamic coastal region, let alone standardized annual monitoring data, hinders efforts to model species’ vulnerability in a region susceptible to sea level rise and development pressure. The most common survey method, standardized amphibian vocal surveys, will detect Anuran reproductive efforts, but is unlikely to ascertain if breeding was successful or to detect salamanders. While it will not replace actual population data, consideration of critical life-history traits and breeding habitat availability can be used to direct management to support long-term species persistence in changing environs. Even common amphibians in coastal conservation areas of Georgia are vulnerable to increasing population isolation caused by unsuitable habitat
Noisy Classical Field Theories with Two Coupled Fields: Dependence of Escape Rates on Relative Field Stiffnesses
Exit times for stochastic Ginzburg-Landau classical field theories with two
or more coupled classical fields depend on the interval length on which the
fields are defined, the potential in which the fields deterministically evolve,
and the relative stiffness of the fields themselves. The latter is of
particular importance in that physical applications will generally require
different relative stiffnesses, but the effect of varying field stiffnesses has
not heretofore been studied. In this paper, we explore the complete phase
diagram of escape times as they depend on the various problem parameters. In
addition to finding a transition in escape rates as the relative stiffness
varies, we also observe a critical slowing down of the string method algorithm
as criticality is approached.Comment: 16 pages, 10 figure
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