23 research outputs found
Efficacy of augmented immunosuppressive therapy for early vasculopathy in heart transplantation
AbstractObjectives. The present study was undertaken to prospectively and comparatively evaluate the role of serial myocardial perfusion imaging and coronary angiography for the detection of early vasculopathy in a large patient population and also to determine the short- and long-term efficacy of augmented immunosuppressive therapy in the potential reversal of the early vasculopathy.Background. Allograft vasculopathy is the commonest cause of death after the first year of heart transplantation. Anecdotal studies have reported the efficacy of augmented immunosuppressive therapy after early detection of vascular involvement. However, no prospective study has evaluated the feasibility of early detection and treatment of allograft vasculopathy.Methods. In 76 cardiac allograft recipients, 230 coronary angiographic and 376 scintigraphic studies were performed in a follow-up period of 8 years. Angiography was performed at 1 month and every year after transplantation, and thallium-201 scintigraphy at 1, 3, 6 and 12 months after transplantation and twice a year thereafter. Prospective follow-up of 76 patients showed that 18 developed either angiographic or scintigraphic evidence of coronary vasculopathy. All episodes were treated with 3-day methylprednisolone pulse and antithymocyte globulin.Results. Twenty-two episodes of vasculopathy were diagnosed and treated in these 18 patients. Of these 22 episodes, two were detected only by angiography, seven by both angiography and scintigraphy, four by scintigraphy and histologic evidence of vasculitis and nine episodes only by thallium-201 scintigraphy studies. Angiographic and/or scintigraphic resolution was observed in 15 of the 22 episodes (68%) with augmented immunosuppression. The likelihood of regression was higher when treatment was instituted within the first year of transplantation (92%) than after the first year (40%) (p = 0.033). Eighty percent of patients who responded to follow-up.Conclusions. The present study suggests that early detection of allograft coronary vasculopathy is feasible with surveillance myocardial perfusion or coronary angiographic studies. When identified early after transplantation, immunosuppressive treatment may result in regression of coronary disease
Guía de actividades docentes para la formación en integración e igualdad de oportunidades por razón de discapacidad en las enseñanzas técnicas: accesibilidad universal y diseño para todos
Estudio financiado por el MEC, Programa Estudio y AnálisisPostprint (published version
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Argonne National Laboratory Reports
The current status of the HYCSOS chemical heat pump and energy conversion system based on metal hydrides is described. Heat transfer fluid loops were insulated and modified for isothermal operation. Software development for HYCSOS manual mode operation was completed. Routines to handle data acquisition, logging, compression, correction and plotting, using a Tektronix Graphics system with flexible disk data storage, provide a rapid and versatile means of presenting HYCSOS data for analysis. Advanced concept heat exchangers to improve the heat transfer of the hydride bed with the heat transfer fluid are discussed. Preliminary tests made with a LaNi5 loaded aluminum foam test unit showed that heat transfer properties are very markedly improved. Thermodynamic expressions are applied to the selection of alloys for use in HYCSOS. The substitution of aluminum for nickel in AB5 type alloys is shown to reduce hysteresis and permits the use of potentially lower cost materials with added flexibility for the optimization of engineering design and performance characteristics of the hydride heat pump system. Transient thermal measurements on hydride beds of CaNi5 and LaNi5 show no deterioration with cycling. Relatively slow heat transfer between the hydride beds and heat transfer fluid in the coiled tube heat exchangers is indicated by temperature lag of the bed and heat transfer fluid. Improved heat transfer is anticipated with aluminum foam heat exchangers
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Argonne National Laboratory Reports
The HYCSOS chemical heat pump and energy conversion system based on metal hydrides are described. The HYCSOS thermal energy storage and recovery modes; the chemical heat pump heating and cooling modes as well as the energy conversion mode are discussed in detail with the aid of heat transfer fluid and hydrogen flow diagrams. The thermodynamic efficiencies of the two metal hydride system are calculated for the heat pump and conversion modes. Design and construction features of a demonstration test facility which utilizes four stainless steel tanks holding 10 lbs. each of either LaNi5 or CaNi5 are given. The operation, instrumentation and control of the system is detailed with the aid of photographs, drawings and a system layout diagram. Initial operation of the system has shown that 33 moles of hydrogen can be transferred from CaNi5 at approximately 100 degrees C to LaNi5 at approximately 40 degrees C and recovered from LaNi5 at approximately 8 degrees C to reform CaNi5H4 at 40 degrees C with cycle times approaching 2 minutes for 50 percent hydrogen transfer. The relevant data pertaining to these experiments are given in graphs and tables. The next phase of operations will be done on the fully insulated system to establish a firmer data base, obtain power balances and determine optimum operating parameters. In order to achieve these goals in a reasonable time frame, a data display and handling system is required. A materials development program is being carried out concurrently with HYCSOS operations. Significant progress is being made in the development of new, more cost effective alloy systems displaying superior properties for heat pump action
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Ion beam spectroscopy as a means of in-situ monitoring of thin film deposition
Low energy (5--15 keV) pulsed beam Ion Scattering Spectroscopy (ISS) and Direct Recoil Spectroscopy (DRS) are surface analytical tools which possess the ability to provide a remarkably wide range of information directly relevant to the growth of multi-component semiconductor, metal and metal oxide thin films and layered structures. Ion beam methods have not been widely used for this purpose because the design of existing commercial instrumentation is unsuitable in terms of vacuum requirements, data acquisition rate, geometric interference with the deposition equipment, and the magnitude of the ion beam dose and consequent film damage required for the acquisition of spectra with reasonable signal-noise ratios. Users of advanced custom-built Time-of-Flight (TOF) instruments have been largely interested in other problems and for the most part, unaware of some of the unique operational characteristics of TOF DR/ISS as they pertain to thin film growth. We discuss here some of the physical properties which may be measured by DR/ISS and describe a physical implementation of the technique which is suitable as a real-time probe of thin film deposition in terms of very low required beam dose, rapid data acquisition, physical non-interference with the deposition equipment and high ambient pressure operation
Mejoría de la vasculopatía del injerto tras la administración de micofenolato mofetil en un niño
Parallel Computing at the NASA Data Assimilation Office (DAO)
This presentation discusses the NASA data assimilation project at the Data Assimilation Office at the NASA/Goddard Space Flight Center. The goal is to produce accurate gridded datasets of atmospheric fields by assimilating a range of observations along with physically consistent model forecasts. This work produces datasets that are used by the climate research community. The data come from conventional sources that are used for weather forecasts (e.g., radiosondes, earth-surface measurements, and satellite temperature retrievals), as well as new sources such as satellites that will be launched under the Mission To Planet Earth Enterprise. An end-to-end Goddard Earth Observing System (GEOS) Data Assimilation System (DAS) currently supports stratospheric flight missions and reanalysis projects for NASA. The current Core of this system (Model, and Analysis) is a multitasking algorithm that runs on Cray J90 and C90 computers at Goddard and NASA Ames Research Center. Future Core computing w..
Resultados Chilenos del registro internacional de factores de riesgo y tratamiento de angina inestable e infarto al miocardio sin supradesnivel del segmento ST: ACCORD (ACute CORonary syndrome Descriptive study)
Phase 1/2 randomized clinical trial of intravenous infusion of umbilical cord mesenchymal stem cells in patients with chronic cardiopathy with stable heart failure (RIMECARD)
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Ion beam spectroscopy as a means of in-situ monitoring of thin film deposition
Low energy (5--15 keV) pulsed beam Ion Scattering Spectroscopy (ISS) and Direct Recoil Spectroscopy (DRS) are surface analytical tools which possess the ability to provide a remarkably wide range of information directly relevant to the growth of multi-component semiconductor, metal and metal oxide thin films and layered structures. Ion beam methods have not been widely used for this purpose because the design of existing commercial instrumentation is unsuitable in terms of vacuum requirements, data acquisition rate, geometric interference with the deposition equipment, and the magnitude of the ion beam dose and consequent film damage required for the acquisition of spectra with reasonable signal-noise ratios. Users of advanced custom-built Time-of-Flight (TOF) instruments have been largely interested in other problems and for the most part, unaware of some of the unique operational characteristics of TOF DR/ISS as they pertain to thin film growth. We discuss here some of the physical properties which may be measured by DR/ISS and describe a physical implementation of the technique which is suitable as a real-time probe of thin film deposition in terms of very low required beam dose, rapid data acquisition, physical non-interference with the deposition equipment and high ambient pressure operation