4 research outputs found
The impact of silent vascular brain burden in cognitive impairment in Parkinson's disease
White matter hyperintensities (WMHs) detected by magnetic
resonance imaging (MRI) of the brain are associated with dementia and cognitive
impairment in the general population and in Alzheimer's disease. Their effect in
cognitive decline and dementia associated with Parkinson's disease (PD) is still
unclear. METHODS: We studied the relationship between WMHs and cognitive state in
111 patients with PD classified as cognitively normal (n = 39), with a mild
cognitive impairment (MCI) (n = 46) or dementia (n = 26), in a cross-sectional
and follow-up study. Cognitive state was evaluated with a comprehensive
neuropsychological battery, and WMHs were identified in FLAIR and T2-weighted
MRI. The burden of WMHs was rated using the Scheltens scale. RESULTS: No
differences in WMHs were found between the three groups in the cross-sectional
study. A negative correlation was observed between semantic fluency and the
subscore for WMHs in the frontal lobe. Of the 36 non-demented patients
re-evaluated after a mean follow-up of 30 months, three patients converted into
MCI and 5 into dementia. Progression of periventricular WMHs was associated with
an increased conversion to dementia. A marginal association between the increase
in total WMHs burden and worsening in the Mini Mental State Examination was
encountered. CONCLUSIONS: White matter hyperintensities do not influence the
cognitive status of patients with PD. Frontal WMHs have a negative impact on
semantic fluency. Brain vascular burden may have an effect on cognitive
impairment in patients with PD as WMHs increase overtime might increase the risk
of conversion to dementia. This finding needs further confirmation in larger
prospective studies
Perfil neuropsicol贸gico de la degeneraci贸n lobar frontotemporal
La degeneraci贸n lobar frontotemporal engloba tres s铆ndromes diferentes, que comparten caracter铆sticas cl铆nicas y patol贸gicas comunes, dificultando as铆 su diagn贸stico en estadios iniciales. Se incluyen en este grupo las tres variantes de la demencia frontotemporal, el s铆ndrome corticobasal y el s铆ndrome de par谩lisis supranuclear progresiva. Se ha llevado a cabo una revisi贸n del perfil neuropsicol贸gico de cada uno de los s铆ndromes, que permita clarificar las caracter铆sticas fundamentales que los definen y ayudar a diferenciarlos de otras demencias. Se ha hecho una revisi贸n de los diferentes trabajos publicados en la literatura al respecto, describiendo las caracter铆sticas cl铆nicas, patol贸gicas y los hallazgos de imagen fundamentales de cada entidad para describir de manera exhaustiva los hallazgos en los diferentes dominios neuropsicol贸gicos y su progresi贸n. Aunque existe un solapamiento entre los s铆ndromes que conforman la degeneraci贸n lobar frontotemporal, la comparaci贸n del perfil neuropsicol贸gico de las mismas entre s铆 y frente a otras demencias permite establecer caracter铆sticas propias de su perfil neuropsicol贸gico para llevar a cabo un diagn贸stico diferencial.Frontotemporal lobar degeneration encompasses
three different syndromes, with clinical and pathologic commonalities, making diagnosis difficult in early
stages. Three subtypes are recognized: frontotemporal
dementia and its three variants, corticobasal syndrome
and supranuclear palsy syndrome. The objective of this
study is to review the neuropsychological features of
each syndrome in order to differentiate amongst subtypes as well as from other forms of dementia.
We review multiple studies from the literature,
highlighting the main clinical features, neuropathology
and changes in brain imaging of each syndrome. Subsequently, we describe the neuropsychological profile
compared to other dementias, and how it progresses
over time.
Although there is an overlap amongst the different
subtypes of frontotemporal lobar degeneration, neuropsychological profiles can help identify subtypes and
discriminate frontotemporal lobar degeneration from
other forms of dementia
Perfil neuropsicol贸gico de la degeneraci贸n lobar frontotemporal
La degeneraci贸n lobar frontotemporal engloba tres s铆ndromes diferentes, que comparten caracter铆sticas cl铆nicas y patol贸gicas comunes, dificultando as铆 su diagn贸stico en estadios iniciales. Se incluyen en este grupo las tres variantes de la demencia frontotemporal, el s铆ndrome corticobasal y el s铆ndrome de par谩lisis supranuclear progresiva. Se ha llevado a cabo una revisi贸n del perfil neuropsicol贸gico de cada uno de los s铆ndromes, que permita clarificar las caracter铆sticas fundamentales que los definen y ayudar a diferenciarlos de otras demencias. Se ha hecho una revisi贸n de los diferentes trabajos publicados en la literatura al respecto, describiendo las caracter铆sticas cl铆nicas, patol贸gicas y los hallazgos de imagen fundamentales de cada entidad para describir de manera exhaustiva los hallazgos en los diferentes dominios neuropsicol贸gicos y su progresi贸n. Aunque existe un solapamiento entre los s铆ndromes que conforman la degeneraci贸n lobar frontotemporal, la comparaci贸n del perfil neuropsicol贸gico de las mismas entre s铆 y frente a otras demencias permite establecer caracter铆sticas propias de su perfil neuropsicol贸gico para llevar a cabo un diagn贸stico diferencial.Frontotemporal lobar degeneration encompasses
three different syndromes, with clinical and pathologic commonalities, making diagnosis difficult in early
stages. Three subtypes are recognized: frontotemporal
dementia and its three variants, corticobasal syndrome
and supranuclear palsy syndrome. The objective of this
study is to review the neuropsychological features of
each syndrome in order to differentiate amongst subtypes as well as from other forms of dementia.
We review multiple studies from the literature,
highlighting the main clinical features, neuropathology
and changes in brain imaging of each syndrome. Subsequently, we describe the neuropsychological profile
compared to other dementias, and how it progresses
over time.
Although there is an overlap amongst the different
subtypes of frontotemporal lobar degeneration, neuropsychological profiles can help identify subtypes and
discriminate frontotemporal lobar degeneration from
other forms of dementia
Correction: Incorrect spelling of last author name in Neuropsychological profile of frontotemporal lobar degeneration
La degeneraci贸n lobar frontotemporal engloba tres
s铆ndromes diferentes, que comparten caracter铆sticas cl铆nicas
y patol贸gicas comunes, dificultando as铆 su diagn贸stico
en estadios iniciales. Se incluyen en este grupo las
tres variantes de la demencia frontotemporal, el s铆ndrome
corticobasal y el s铆ndrome de par谩lisis supranuclear
progresiva. Se ha llevado a cabo una revisi贸n del perfil
neuropsicol贸gico de cada uno de los s铆ndromes, que
permita clarificar las caracter铆sticas fundamentales que
los definen y ayudar a diferenciarlos de otras demencias.
Se ha hecho una revisi贸n de los diferentes trabajos
publicados en la literatura al respecto, describiendo las
caracter铆sticas cl铆nicas, patol贸gicas y los hallazgos de
imagen fundamentales de cada entidad para describir
de manera exhaustiva los hallazgos en los diferentes
dominios neuropsicol贸gicos y su progresi贸n.
Aunque existe un solapamiento entre los s铆ndromes
que conforman la degeneraci贸n lobar frontotemporal,
la comparaci贸n del perfil neuropsicol贸gico de
las mismas entre s铆 y frente a otras demencias permite
establecer caracter铆sticas propias de su perfil neuropsicol贸gico
para llevar a cabo un diagn贸stico diferencial.Frontotemporal lobar degeneration encompasses
three different syndromes, with clinical and pathologic
commonalities, making diagnosis difficult in early
stages. Three subtypes are recognized: frontotemporal
dementia and its three variants, corticobasal syndrome
and supranuclear palsy syndrome. The objective of this
study is to review the neuropsychological features of
each syndrome in order to differentiate amongst subtypes
as well as from other forms of dementia.
We review multiple studies from the literature,
highlighting the main clinical features, neuropathology
and changes in brain imaging of each syndrome. Subsequently,
we describe the neuropsychological profile
compared to other dementias, and how it progresses
over time.
Although there is an overlap amongst the different
subtypes of frontotemporal lobar degeneration, neuropsychological
profiles can help identify subtypes and
discriminate frontotemporal lobar degeneration from
other forms of dementia