Identification and functional characterisation of enzymes in the glycosylation pathway of Leishmania major

[no abstract

Are serial CA 19-9 kinetics helpful in predicting survival in patients with advanced or metastatic pancreatic cancer treated with gemcitabine and cisplatin?

Background: Serial kinetics of serum CA 19-9 levels have been reported to reflect response and survival in patients with pancreatic cancer undergoing surgery, radiotherapy, and chemotherapy. We prospectively studied serial kinetics of serum CA 19-9 levels of patients with locally advanced or metastatic disease treated with gemcitabine and cisplatin. Patients and Methods: Enrolled in the study were 87 patients (female/male = 26/61; stage III/IV disease = 24/63). Patients received gemcitabine 1,000 mg/m(2) on days 1, 8, and 15 plus cisplatin 50 mg/m(2) on days 1 and 15, every 4 weeks. Serum samples were collected at the onset of chemotherapy and before the start of a new treatment cycle (day 28). Results: 77 of 87 patients (88.5%) with initially elevated CA 19-9 levels were included for evaluation. According to imaging criteria, 4 (5.2%) achieved a complete remission and 11 (14.3%) achieved partial remission, yielding an overall response rate of 19.5%. 43 (55.8%) patients were CA 19-9 responders, defined by greater than or equal to50% decrease in CA 19-9 serum levels within 2 months after treatment initiation. Except for one, all patients who had responded by imaging criteria (n = 14) fulfilled the criterion of a CA 19-9 responder. Despite being characterized as non-responders by CT-imaging criteria (stable/progressive disease), 29 patients were classified as CA 19-9 responders (positive predictive value 32.5%). Independent of the response evaluation by CT, CA 19-9 responders survived significantly longer than CA 19-9 non-responders (295 d; 95% CI: 285-445 vs. 174 d; 95% CI: 134-198; p = 0.022). Conclusion: CA 19-9 kinetics in serum serve as an early and reliable indicator of response and help to predict survival in patients with advanced pancreatic cancer receiving effective treatment with gemcitabine and cisplatin

Positive Effects of Surfing on Psychological Wellbeing for Children with Developmental Difficulties

Children with developmental disorders or disabilities often experience a wide range of difficulties and reduced quality of life. Surfing is gaining popularity as a sport that can promote psychological well-being, but research is still scarce. The current study aimed to investigate the effects of surfing on the quality of life of children with developmental difficulties. Participants were 84 children with Down syndrome, autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD). Quality of life was measured by a parent-rated questionnaire (KIDSCREEN-27) before and after a series of three adapted surfing lessons. Additionally, responses on an evaluation questionnaire were qualitatively analysed to gain more insight into the experiences of children and parents. Results of the KIDSCREEN showed a significant increase in the children's quality of life after 3 surfing lessons for the Total score, as well as subscale scores for Psychological well-being, Social support & peers and School. A trend towards significance was found for the subscale Autonomy & parent relation. Qualitative analysis of evaluation data showed consistent positive experiences by children as well as parents. According to parents, surfing improved the child's mood, self-confidence, self-esteem and social-emotional functioning. They saw their child enjoy the lessons, conquering their fears, feeling safe and free. According to many parents, effects transferred into their child's daily life. Surfing in a safe, structured and positive environment holds promise to improve the quality of life for children with developmental difficulties. Findings provide valuable insights into the scope of these effects and possible working mechanisms underlying the effects

Проект установки получения синтез-газа

ВКР 91 страницу, 6 рисунков, 40 таблиц, 24 литературных источника. Ключевые слова: синтез-газ, конверсия, применение синтез-газа, сырье, природный газ, технологическая схема, производство, метан, метанол. Объект разработки: производство синтез-газа методом паровой каталитической конверсии природного газа. Цель работы: изучение всех физико - химических свойств процесса и их влияния на протекание реакции, а также конструирование основного аппарата установки получения синтез - газа. В результате исследования выполнен расчет материального и теплового балансов, также конструктивный и механический расчеты, на основании которых был выполнен чертеж основного аппарата. ВКР выполнена на кафедре ТОВПМ ст. группы 2Д2А Якимовой В.А., под руководством к.х.н. Мананковой А.А.The final qualifying work contains 91 page, 6 figures, 40 tables and 24 literature sources. Content words are conversion, synthesis gas. The object of the development is the production of synthesis gas by catalytic steam reforming of natural gas. The mission is the study of physical - chemical properties of the process and their influence on the reaction, as well as the construction of the main unit installation producing synthesis - gas. The study was carried out payment of material and heat balances, the constructive and mechanical calculations, drawing on the basis of which the main unit was made. The final qualifying work carried out at the Department of TOVPM student group 2D2A Vera Yakimova, under the leadership of Candidate of Chemical Sciences Ann Manankova

Positive Effects of Surfing on Psychological Wellbeing for Children with Developmental Difficulties

Children with developmental disorders or disabilities often experience a wide range of difficulties and reduced quality of life. Surfing is gaining popularity as a sport that can promote psychological well-being, but research is still scarce. The current study aimed to investigate the effects of surfing on the quality of life of children with developmental difficulties. Participants were 84 children with Down syndrome, autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD). Quality of life was measured by a parent-rated questionnaire (KIDSCREEN-27) before and after a series of three adapted surfing lessons. Additionally, responses on an evaluation questionnaire were qualitatively analysed to gain more insight into the experiences of children and parents. Results of the KIDSCREEN showed a significant increase in the children's quality of life after 3 surfing lessons for the Total score, as well as subscale scores for Psychological well-being, Social support & peers and School. A trend towards significance was found for the subscale Autonomy & parent relation. Qualitative analysis of evaluation data showed consistent positive experiences by children as well as parents. According to parents, surfing improved the child's mood, self-confidence, self-esteem and social-emotional functioning. They saw their child enjoy the lessons, conquering their fears, feeling safe and free. According to many parents, effects transferred into their child's daily life. Surfing in a safe, structured and positive environment holds promise to improve the quality of life for children with developmental difficulties. Findings provide valuable insights into the scope of these effects and possible working mechanisms underlying the effects