Demonstration of a sterilizable solid rocket motor system

A solid propellant rocket motor containing 60.9 Kg (134-lb) of propellant was successfully static fired after being subjected to eight heat sterilization cycles (three 54-hour cycles plus five 40-hour cycles) at 125 C (257 F). The test motor, a modified SVM-3 chamber, incorporated a flexible grain retention system of EPR rubber to relieve thermal shrinkage stresses. The propellant used in the motor was ANB-3438, and 84 wt% solids system (18 wt% aluminum) containing 66 wt% stabilized ammonium perchlorate oxidizer and a saturated hydroxylterminated polybutadiene binder. Bonding of the propellant to the EPR insulation (GenGard V-4030) was provided by the use of SD-886, an epoxy urethane restriction

Relationships between different nutritional anthropometric statuses and health-related fitness of South African primary school children

Background A double burden of both under- and over-nutrition exists among South African children. Aim Describe associations between nutritional statuses and health-related fitness test performances. Subjects and methods Height and weight of 10 285 children (6-13 years; n=5604 boys and 4681 girls) were measured and used to calculate: body mass index (BMI), and prevalence of overweight and obesity, stunting, wasting, and underweight. Physical fitness scores for standing long jump, shuttle run, sit-and-reach, sit-up (EUROFIT) and cricket ball throw were assessed. Age and gender specific z-scores were calculated for these variables. Physical fitness for each nutritional status group was compared to children of normal weight. Results Compared to normal weight children, overweight and obese children scored lower on all fitness tests (p<.001), except cricket ball throw (p=.235) and sit-and-reach (p=.015). Stunted and underweight children performed poorer than normal weight children on most fitness tests (p<.001), except sit-and-reach (stunted: p=.829; underweight: p=.538) and shuttle run (underweight: p=.017). Performance of wasted children was not as highly compromised as other undernourished groups, but they performed poorer on the cricket ball throw (p<.001). Conclusions When compared to normal weight children, both under- and over-nourished children performed poorer on some, but not all, health-related fitness tests

High Dimensional Classification with combined Adaptive Sparse PLS and Logistic Regression

Motivation: The high dimensionality of genomic data calls for the development of specific classification methodologies, especially to prevent over-optimistic predictions. This challenge can be tackled by compression and variable selection, which combined constitute a powerful framework for classification, as well as data visualization and interpretation. However, current proposed combinations lead to instable and non convergent methods due to inappropriate computational frameworks. We hereby propose a stable and convergent approach for classification in high dimensional based on sparse Partial Least Squares (sparse PLS). Results: We start by proposing a new solution for the sparse PLS problem that is based on proximal operators for the case of univariate responses. Then we develop an adaptive version of the sparse PLS for classification, which combines iterative optimization of logistic regression and sparse PLS to ensure convergence and stability. Our results are confirmed on synthetic and experimental data. In particular we show how crucial convergence and stability can be when cross-validation is involved for calibration purposes. Using gene expression data we explore the prediction of breast cancer relapse. We also propose a multicategorial version of our method on the prediction of cell-types based on single-cell expression data. Availability: Our approach is implemented in the plsgenomics R-package.Comment: 9 pages, 3 figures, 4 tables + Supplementary Materials 8 pages, 3 figures, 10 table

DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8+ T Cell Responses, Enabling Faster Resolution of Influenza Disease

Current influenza vaccines are effective but imperfect, failing to cover against emerging strains of virus and requiring seasonal administration to protect against new strains. A key step to improving influenza vaccines is to improve our understanding of vaccine induced protection. Whilst it is clear that antibodies play a protective role, vaccine induced CD8+ T cells can improve protection. To further explore the role of CD8+ T cells we used a DNA vaccine that encodes antigen dimerised to an immune cell targeting module. Immunising CB6F1 mice with the DNA vaccine in a heterologous prime boost regime with the seasonal protein vaccine improved the resolution of influenza disease compared to protein alone. This improved disease resolution was dependent on CD8+ T cells. However, DNA vaccine regimes that induced CD8+ T cells alone were not protective and did not boost the protection provided by protein. The MHC targeting module used was an anti-I-Ed single chain antibody specific to the BALB/c strain of mice. To test the role of MHC targeting we compared the response between BALB/c, C57BL/6 mice and an F1 cross of the two strains (CB6F1). BALB/c mice were protected, C57BL/6 were not and the F1 had an intermediate phenotype; showing that the targeting of antigen is important in the response. Based on these findings, and in agreement with other studies using different vaccines, we conclude that in addition to antibody, inducing a protective CD8 response is important in future influenza vaccines

Rubidium and lead abundances in giant stars of the globular clusters M4 and M5

We present measurements of the neutron-capture elements Rb and Pb for bright giants in the globular clusters M4 and M5. The clusters are of similar metallicity ([Fe/H] = -1.2) but M4 is decidedly s-process enriched relative to M5: [Ba/Fe] = +0.6 for M4 but 0.0 for M5. The Rb and Pb abundances were derived by comparing synthetic spectra with high-resolution, high signal-to-noise ratio spectra obtained with MIKE on the Magellan telescope. Abundances of Y, Zr, La, and Eu were also obtained. In M4, the mean abundances from 12 giants are [Rb/Fe] = 0.39 +/- 0.02 (sigma = 0.07), [Rb/Zr] = 0.17 +/- 0.03 (sigma = 0.08), and [Pb/Fe] = 0.30 +/- 0.02 (sigma = 0.07). In M5, the mean abundances from two giants are [Rb/Fe] = 0.00 +/- 0.05 (sigma = 0.06), [Rb/Zr] = 0.08 +/- 0.08 (sigma = 0.11), and [Pb/Fe] = -0.35 +/- 0.02 (sigma = 0.04). Within the measurement uncertainties, the abundance ratios [Rb/Fe], [Pb/Fe] and [Rb/X] for X = Y, Zr, La are constant from star-to-star in each cluster and none of these ratios are correlated with O or Na abundances. While M4 has a higher Rb abundance than M5, the ratios [Rb/X] are similar in both clusters indicating that the nature of the s-products are very similar for each cluster but the gas from which M4's stars formed had a higher concentration of these products.Comment: Accepted for publication in Ap

The Chemical Compositions of the SRd Variable Stars-- II. WY Andromedae, VW Eridani, and UW Librae

Chemical compositions are derived from high-resolution spectra for three stars classed as SRd variables in the General Catalogue of Variable Stars. These stars are shown to be metal-poor supergiants: WY And with [Fe/H] = -1.0, VW Eri with [Fe/H] = -1.8, and UW Lib with [Fe/H] = -1.2. Their compositions are identical to within the measurement errors with the compositions of subdwarfs, subgiants, and less evolved giants of the same FeH. The stars are at the tip of the first giant branch or in the early stages of evolution along the asymptotic giant branch (AGB). There is no convincing evidence that these SRd variables are experiencing thermal pulsing and the third dredge-up on the AGB. The SRds appear to be the cool limit of the sequence of RV Tauri variables.Comment: 14 pages, 1 figure, 4 table