Collisions and Mergers of Disk Galaxies: Hydrodynamics of Star Forming Gas

We summarize the results of numerical simulations of colliding gas-rich disk galaxies in which the impact velocity is set parallel to the spin axes of the two galaxies. The effects of varying the impact speed are studied with particular attention to the resulting gaseous structures and shockwave patterns, and the time needed to produce these structures. The simulations employ an N-body treatment of the stars and dark matter, together with an SPH treatment of the gas, in which all components of the models are gravitationally active. The results indicate that for such impact geometries, collisions can lead to the very rapid formation of a central, rapidly rotating, dense gas disk, and that in all cases extensive star formation is predicted by the very high gas densities and prevalence of shocks, both in the nucleus and out in the galactic disks. As the dense nucleus is forming, gas and stars are dispersed over very large volumes, and only fall back towards the nucleus over long times. In the case of low impact velocities, this takes an order of magnitude more time than that needed for the formation of a dense nucleus.Comment: To be published in Proceedings of 'The Evolution of Galaxies III- From simple approaches to self-consistent models,' held in Kiel, Germany, July 2002, Astrophysics and Space Science (Kluwer), vol. 284, p. 479, 200

Slope, grain size, and roughness controls on dry sediment transport and storage on steep hillslopes

Existing hillslope sediment transport models developed for low-relief, soil-mantled landscapes are poorly suited to explain the coupling between steep rocky hillslopes and headwater channels. Here we address this knowledge gap using a series of field and numerical experiments to inform a particle-based model of sediment transport by dry ravel—a mechanism of granular transport characteristic of steep hillslopes. We find that particle travel distance increases as a function of the ratio of particle diameter to fine-scale (1 m) topographic variability associated with rocky landscapes. Applying a 2-D dry-ravel-routing model to lidar-derived surface topography, we show how spatial patterns of local and nonlocal transport control connectivity between hillslopes and steep headwater channels that generate debris flows through failure of ravel-filled channels following wildfire. Our results corroborate field observations of a patchy transition from soil-mantled to bedrock landscapes and suggest that there is a dynamic interplay between sediment storage, roughness, grain sorting, and transport even on hillslopes that well exceed the angle of repose

The hidden burden of adult allergic rhinitis : UK healthcare resource utilisation survey

Funding Funding for this survey was provided by Meda Pharma.Peer reviewedPublisher PD

Search algorithms as a framework for the optimization of drug combinations

Combination therapies are often needed for effective clinical outcomes in the management of complex diseases, but presently they are generally based on empirical clinical experience. Here we suggest a novel application of search algorithms, originally developed for digital communication, modified to optimize combinations of therapeutic interventions. In biological experiments measuring the restoration of the decline with age in heart function and exercise capacity in Drosophila melanogaster, we found that search algorithms correctly identified optimal combinations of four drugs with only one third of the tests performed in a fully factorial search. In experiments identifying combinations of three doses of up to six drugs for selective killing of human cancer cells, search algorithms resulted in a highly significant enrichment of selective combinations compared with random searches. In simulations using a network model of cell death, we found that the search algorithms identified the optimal combinations of 6-9 interventions in 80-90% of tests, compared with 15-30% for an equivalent random search. These findings suggest that modified search algorithms from information theory have the potential to enhance the discovery of novel therapeutic drug combinations. This report also helps to frame a biomedical problem that will benefit from an interdisciplinary effort and suggests a general strategy for its solution.Comment: 36 pages, 10 figures, revised versio

Canine distemper virus persistence in demyelinating encephalitis by swift intracellular cell-to-cell spread in astrocytes is controlled by the viral attachment protein

The mechanism of viral persistence, the driving force behind the chronic progression of inflammatory demyelination in canine distemper virus (CDV) infection, is associated with non-cytolytic viral cell-to-cell spread. Here, we studied the molecular mechanisms of viral spread of a recombinant fluorescent protein-expressing virulent CDV in primary canine astrocyte cultures. Time-lapse video microscopy documented that CDV spread was very efficient using cell processes contacting remote target cells. Strikingly, CDV transmission to remote cells could occur in less than 6 h, suggesting that a complete viral cycle with production of extracellular free particles was not essential in enabling CDV to spread in glial cells. Titration experiments and electron microscopy confirmed a very low CDV particle production despite higher titers of membrane-associated viruses. Interestingly, confocal laser microscopy and lentivirus transduction indicated expression and functionality of the viral fusion machinery, consisting of the viral fusion (F) and attachment (H) glycoproteins, at the cell surface. Importantly, using a single-cycle infectious recombinant H-knockout, H-complemented virus, we demonstrated that H, and thus potentially the viral fusion complex, was necessary to enable CDV spread. Furthermore, since we could not detect CD150/SLAM expression in brain cells, the presence of a yet non-identified glial receptor for CDV was suggested. Altogether, our findings indicate that persistence in CDV infection results from intracellular cell-to-cell transmission requiring the CDV-H protein. Viral transfer, happening selectively at the tip of astrocytic processes, may help the virus to cover long distances in the astroglial network, “outrunning” the host’s immune response in demyelinating plaques, thus continuously eliciting new lesions

Prophylactic and therapeutic activity of fully human monoclonal antibodies directed against Influenza A M2 protein

Influenza virus infection is a prevalent disease in humans. Antibodies against hemagglutinin have been shown to prevent infection and hence hemagglutinin is the major constituent of current vaccines. Antibodies directed against the highly conserved extracellular domain of M2 have also been shown to mediate protection against Influenza A infection in various animal models. Active vaccination is generally considered the best approach to combat viral diseases. However, passive immunization is an attractive alternative, particularly in acutely exposed or immune compromized individuals, young children and the elderly. We recently described a novel method for the rapid isolation of natural human antibodies by mammalian cell display. Here we used this approach to isolate human monoclonal antibodies directed against the highly conserved extracellular domain of the Influenza A M2 protein. The identified antibodies bound M2 peptide with high affinities, recognized native cell-surface expressed M2 and protected mice from a lethal influenza virus challenge. Moreover, therapeutic treatment up to 2 days after infection was effective, suggesting that M2-specific monoclonals have a great potential as immunotherapeutic agents against Influenza infection

Millisecond Oscillations in X-Ray Binaries

The first millisecond X-ray variability phenomena from accreting compact objects have recently been discovered with the Rossi X-ray Timing Explorer. Three new phenomena are observed from low-mass X-ray binaries containing low-magnetic-field neutron stars: millisecond pulsations, burst oscillations and kiloHertz quasi-periodic oscillations. Models for these new phenomena involve the neutron star spin, and orbital motion closely around the neutron star and rely explicitly on our understanding of strong gravity and dense matter. I review the observations of these new neutron-star phenomena and possibly related ones in black-hole candidates, and describe the attempts to use them to perform measurements of fundamental physical interest in these systems.Comment: 40 pages, 17 figures, 4 tables - submitted to the Annual Review of Astronomy and Astrophysics; to appear September 200

Generalized Flows around Neutron Stars

In this chapter, we present a brief and non-exhaustive review of the developments of theoretical models for accretion flows around neutron stars. A somewhat chronological summary of crucial observations and modelling of timing and spectral properties are given in sections 2 and 3. In section 4, we argue why and how the Two-Component Advective Flow (TCAF) solution can be applied to the cases of neutron stars when suitable modifications are made for the NSs. We showcase some of our findings from Monte Carlo and Smoothed Particle Hydrodynamic simulations which further strengthens the points raised in section 4. In summary, we remark on the possibility of future works using TCAF for both weakly magnetic and magnetic Neutron Stars.Comment: 15 pages, 7 figures. arXiv admin note: text overlap with arXiv:1901.0084

Maximising response to postal questionnaires – A systematic review of randomised trials in health research

Background Postal self-completion questionnaires offer one of the least expensive modes of collecting patient based outcomes in health care research. The purpose of this review is to assess the efficacy of methods of increasing response to postal questionnaires in health care studies on patient populations. Methods The following databases were searched: Medline, Embase, CENTRAL, CDSR, PsycINFO, NRR and ZETOC. Reference lists of relevant reviews and relevant journals were hand searched. Inclusion criteria were randomised trials of strategies to improve questionnaire response in health care research on patient populations. Response rate was defined as the percentage of questionnaires returned after all follow-up efforts. Study quality was assessed by two independent reviewers. The Mantel-Haenszel method was used to calculate the pooled odds ratios. Results Thirteen studies reporting fifteen trials were included. Implementation of reminder letters and telephone contact had the most significant effect on response rates (odds ratio 3.7, 95% confidence interval 2.30 to 5.97 p = <0.00001). Shorter questionnaires also improved response rates to a lesser degree (odds ratio 1.4, 95% confidence interval 1.19 to 1.54). No evidence was found that incentives, re-ordering of questions or including an information brochure with the questionnaire confer any additional advantage. Conclusion Implementing repeat mailing strategies and/or telephone reminders may improve response to postal questionnaires in health care research. Making the questionnaire shorter may also improve response rates. There is a lack of evidence to suggest that incentives are useful. In the context of health care research all strategies to improve response to postal questionnaires require further evaluation