Role of neutrophil-lymphocyte ratio in determining the outcomes of preterm premature rupture of membranes

Background: Premature Rupture of Membranes (PROM) is a significant obstetric problem. Evaluation of neutorphil-lymphocyte ratio (NLR) is expected to throw light on the potential scope of early prediction of PPROM. With this background, the present study was carried out to compare the NLR among preterm PROM and healthy controls to evaluate the predictive role of NLR and platelet-lymphocyte ratio (PLR).Methods: This case control study was carried out among 101 pregnant women 44 pregnant women diagnosed with Preterm PROM and 55 term gestation matched healthy controls. Laboratory parameters (including complete blood count were measured. PLR was calculated as the number of platelets divided by the lymphocyte count, and NLR was calculated by dividing the neutrophil Count by the lymphocyte count, both of which were obtained from the same blood samples.Results: All the inflammatory markers including total count, neutrophil count, NLR and PLR ratios were elevated among PPROM group compared to the controls. The observed differences in the mean levels of these parameters were statistically significant (p<0.05).Conclusions: It may be considered that monitoring of NLR during second and early third trimesters as a routine practice among high risk mothers can significantly help in early prediction of PPROM and help in minimizing adverse maternal and neonatal outcomes

AN ASSESSMENT ON BUCCAL MUCOADHESIVE DRUG DELIVERY SYSTEM

Buccal drug delivery system (BDDS) has won a variety of exposure and traction as it possesses plenty of advantages and benefits as evaluate to different mucosal drug delivery systems. Buccal path for systemic drug delivery, the use of mucoadhesive polymers twill significantly increase the efficacy of many tablets, has been of outstanding interest over the previous couple of decades. This article affords a precise of BDDS mechanisms, consisting of a composition of the oral mucosa, delivery mechanism, numerous forms of BDDS, formulation, assessment and application of BDDS. Additionally, this text affords a precis over the patents, advertised products and destiny factors of BDDS. In this evaluation article, we've got tried to assemble the maximum significant reports (1988 to 2021) of formulation, assessment, application, patents of BDDS. This review will help pharmaceutical researchers to clarify the potential of BDDS to overcome the various existing drug delivery dispute like the efficiency of absorption, permeability and bioavailability of drugs

A Hybrid of Improved Bulls and Weighted Round Robin to optimize the Leader and Load Balancing in Cloud and Distributed Computing Environment

Day by Day there is increase of internet users which leads to increase the traffic in the network which causing the generation of huge data. It requires the balancing of network load on the network servers with different Load balancing techniques. It is also required to have efficient algorithm to analysis the huge data in distributed manner to identify the leader to act as centralized point of contact for services. If we audit on the heap adjusting systems, there are a few potential outcomes to upgrade the methods. In the present scenario, we have the methods, round robin algorithm (static load adjusting), Weighted Round Robin algorithm and Least Load algorithm (Dynamic Load Balancing). A researcher D. Chitra Devi .et .al has given the idea of enhanced weighted round robin algorithm (EWRR) which gives much better reaction when contrasted with basic round robin calculation. Another scholar Rashmi Saini et. al recommended the half breed of round robin calculation and minimum Load Algorithm. From the above scholars� articles, I hereby propose a resolution by improved Bulls algorithm along with Weighted Round Robin (WRR) algorithm to achieve high performance in Distributed and Cloud Computing domain in terms of leader election from a group of distributed and non-failed processes, load balancing dynamically and coordinate other nodes. Bulls algorithm uses the following message types: � Election Message: Sent to announce election. � Answer (Alive) Message: Responds to the Election message. � Coordinator (Victory) Message: Sent by winner of the election to announce victory. When coordinator fails to recover a process P, from failure or detecting before failure, the process P performs the following actions: 1. If P has the highest process id, it sends a Victory message to all other processes and becomes the new Coordinator. Otherwise, P broadcasts an Election message to all other processes with higher process IDs than itself. 2. If P does not receive any Election message, then it broadcasts a Victory message to all other processes and becomes the Coordinator. 3. If P receives an Answer from a process with a higher ID, it sends no further messages for this election and waits for a Victory message. When there is no Victory message after a stipulated period, it restarts the process from the beginning. 4. If P receives an Election message from another process with a lower ID it sends an Answer message back and starts the election process at the beginning, by sending an Election message to higher-numbered processes. 5. If P receives a Coordinator message, it treats the sender as the coordinator

Efficient Degradation of Feather by Keratinase Producing Bacillus

Keratinase producing microorganisms are being increasingly utilized for degradation and recycling of poultry feather waste. Two native strains BF11 (Bacillus subtilis) and BF21 (Bacillus cereus) degrading keratin completely were characterized. The native strains produced more than 10 KU/mL of enzyme. Strain improvement resulted in isolation of MBF11 and MBF21 from BF11 and BF21 isolates, respectively. Optimization of nutritional and physical parameters of these MBF isolates at laboratory scale increased the overall keratinase activity by 50-fold resulting in a yield of 518–520 KU/mL. Fermentation media designed with starch as carbon source and soya bean meal as nitrogen source supported high levels of enzyme production. The optimum conditions for enzyme production were determined to be pH 8.5 and temperatures of 45–55°C for MBF11 and 37°C for MBF21, respectively. Culture filtrate showed a significant increase in the amounts of cysteine, cystine, methionine, and total free amino acids during the fermentation period. The ratio of organic sulphur concentration was also considerably higher than that of the inorganic sulphate in the culture filtrate suggesting the hydrolysis of disulphide by the isolates

Length-weight relationship and certain biological aspects of the Indian white shrimp Fenneropenaeus indicus (H. Milne Edwards, 1837) exploited by trawls in the Arabian Sea off Kerala coast, India

Length-weight relationship (LWR), sex ratio and maturity of Fenneropenaeus indicus (H. Milne Edwards, 1837), was analysed based on samplings from coastal trawl fishing grounds in the Arabian Sea off Kerala coast, India. The male to female ratio (1:1.27) did not vary significantly from the hypothetical 1:1 ratio. Length at maturity (Lm50) was estimated at 122 mm total length for females. The LWR did not differ significantly between male and female shrimps. The information generated from this study will enhance knowledge on the biology of the species and assist in assessment and management of its stock

Insilico interaction analysis of herbal bioactive molecules with Penicillin binding protein in staphylococcus aureus

Staphylococcus aureus is an opportunistic bacterial pathogen associated with asymptomatic colonization of the skin and mucosal surfaces of normal humans. Staphylococcus aureus isolates are often multidrug resistant. Antibiotics resistant Staphylococcus aureus is an emerging concern in the medical field. Due to their increasing resistance to numerous antibiotics, screening for alternate compound is required. Penicillin binding protein (PBP) was considered as an essential drug target for inhibiting bacterial growth. Molecular docking studies were performed to identify the lead molecule against Penicillin binding protein. Interaction of PBP with the plant derived compounds indicates the effective interaction of rosmarinic acid with highest fitness score and maximum number of hydrogen bonds (h-bonds). The study concludes that rosmarinic acid may be effective as an inhibitor for PBP and hence, can be regarded as a potential drug candidate for treating β-lactam resistant Staphylococcus aureu

A STUDY ON WEALTH MANAGEMENT AND CLIENT INVESTMENT SERVICE, BANGALORE

Wealth management and client investment services are essential components of the financial industry, catering to the complex and diverse needs of clients seeking to grow, preserve, and manage their wealth. Whether through personalized advisory services or technology-driven solutions, the overarching goal is to provide clients with a path toward financial security and prosperity. the evolving landscape of wealth management, with a particular emphasis on the fusion of traditional and digital service models. This dynamic environment offers clients a range of options to suit their preferences and adapt to changing market conditions. The fundamental concepts and principles that under pin the wealth management and client investment services landscape, shedding light on the paramount importance of aligning financial strategies with clients' unique goals, risk tolerances, and investment time horizons. Furthermore, this abstract highlights the ongoing transformation within wealth management, especially the convergence of traditional and digital service models, catering to clients' diverse preferences and adapting to a rapidly changing economic and regulatory environment. Wealth management's changing environment, with a focus on the blending of traditional and digital service approaches. Customers have a variety of options in this dynamic environment to fit their interests and adjust to shifting market conditions. The core ideas and principles that guide wealth management and client investment services, emphasizing the critical role that matching financial strategies to customers' individual objectives, risk tolerances, and time horizons plays in their success. In order to meet the complicated and varied demands of clients looking to increase, maintain, and manage their wealth, client investment services and wealth management are crucial elements of the financial sector. The main objective is to offer clients a route toward financial security and prosperity, whether through individualized consulting services or technology-driven solutions. In addition, this emphasizes the ongoing transition in wealth management, particularly the fusion of traditional and digital service models, addressing the varied preferences of customers, and adjusting to a quickly altering regulatory and economic environment