ALTERATIONS OF LIPID PROFILE LEVELS IN 7,12-DIMETHYLBENZ(A)ANTHRACENE INDUCED ULCERATIVE COLITIS RAT MODEL

Objective: Ulcerative colitis is a type of inflammatory bowel disease is a chronic gastrointestinal disorder characterized by intestinal inflammation and mucosal tissue damage. We examined the lipid profile levels in murine model of 7,12 Dimethylbenz(a)anthracene induced ulcerative colitis.Methods: Serum was separated from whole blood and was used to determine the lipid profile such as total cholesterol (TC), phospholipids (PL), triglycerides (TG), free fatty acids, high density lipoprotein (HDL-C) and low density lipoprotein (HDL-C).Results: Ulcerative colitis rats exhibit low level of low density lipoprotein cholesterol and total cholesterol. No significant difference was observed in high density lipoprotein and triglycerides and significant difference was observed in phospholipids and free fatty acid serum levels. This communication highlights the lipid profile that occurs in ulcerative colitis.Conclusion: This study, thus, provides valuable information about the disturbances in the lipids and lipoproteins occur in ulcerative colitis.Keywords: Ulcerative colitis, 7,12-Dimethylbenz(a)anthracene, Lipoprotein, Low-density lipoprotein, Phospholipids

Frequency Reconfigurable Split Ring Antenna for LTE And WiMAX Applications

This paper presents frequency reconfigurable dual band antenna for WiMAX and LTE 2500 band applications using four PIN diode switches. The antenna is compact in size with dimensions of 30 x 30 x 0.8 mm3 and designed on FR-4 dielectric substrate with a partial ground plane. The fabricated antenna operates in the frequency range of LTE and WiMAX (2.5-2.69 GHz and 3.4-3.6 GHz) respectively.  The frequencies can be controlled by using PIN diodes and antenna attained the gain ranging of 3.34-4.46 dBi. This designed antenna resonating at 2.52 and 3.49 GHz when the PIN diodes are in ON state and resonating at 2.68 and 3.58 GHz when PIN diodes are in OFF state. The proposed antenna has bidirectional radiation at upper frequency bands and unidirectional at lower frequency bands. The proposed split ring structured antenna has the radiation efficiency of 94.12% at 2.52 GHz and 90.34% at 3.49 GHz in ON state. Antenna providing good agreement between the measured (Antenna measurement setup with VNA) and simulated results (Ansys-HFSS)

7′-(Naphthalen-1-yl)-5′′-[(naphthalen-2-yl)­methyl­idene]-1′,3′,5′,6′,7′,7a′-hexa­hydro­dispiro­[acenaphthene-1,5′-pyrrolo­[1,2-c]thia­zole-6′,3′′-piperidine]-2(1H),4′′-dione

In the title compound, C43H34N2O2S, the six-membered piperidine ring adopts a half-chair conformation. The five-membered thia­zole ring adopts a slightly twisted envelope conformation and the pyrrole ring adopts an envelope conformation; in each case, the C atom linking the rings is the flap atom. The mol­ecular structure features inter- and intra­molecular C—H⋯O inter­actions. Furthermore, the crystal packing is stabilized by four inter­molecular C—H⋯π inter­actions

Crystal structure of 2-benzylamino-4-(4-bromo-phenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

JS and RAN thank the management of The Madura College (Autonomous), Madurai, for their encouragement and support. RRK thanks the University Grants Commission, New Delhi, for funds through Major Research Project F. No. 42–242/2013 (SR).Peer reviewedPublisher PD

rac-2-Hy­droxy-2-(2-oxocyclo­pent­yl)-1H-indene-1,3(2H)-dione

In the title compound, C14H12O4, the indene unit is essentially planar [r.m.s. deviation = 0.0309 (1) Å] and the cyclo­penta­none ring adopts a twist form. In the crystal, mol­ecules are joined via pairs of O—H⋯O hydrogen bonds into centrosymmetric dimers

(3R*,4R*,5S*)-4-(4-Methyl­phen­yl)-2,3-diphenyl-7-[(R*)-1-phenyl­ethyl]-1-oxa-2,7-diaza­spiro­[4.5]decan-10-one oxime

In the title compound, C34H35N3O2, the polysubstituted piperidine ring adopts a chair conformation and the isoxazolidine ring is in an envelope form. The mol­ecules are linked into a chain along the b axis by O—H⋯N, C—H⋯O and C—H⋯N inter­actions. The chains are cross-linked via weak C—H⋯π inter­actions

5′′-(4-Meth­oxy­benzyl­idene)-7′-(4-meth­oxy­phen­yl)-1′′-methyl-5′,6′,7′,7a’-tetra­hydro­dispiro­[acenaphthene-1,5′-pyrrolo­[1,2-c][1,3]thia­zole-6′,3′′-piperidine]-2,4′′-dione

In the title compound, C37H34N2O4S, the piperidine ring adopts a half-chair conformation. The thia­zole ring adopts a slightly twisted envelope conformation and the pyrrole ring adopts an envelope conformation; in each case, the C atom linking the rings is the flap atom. An intra­molecular C—H⋯O inter­action is noted. The crystal structure is stabilized by C—H⋯O and C—H⋯π inter­actions

2,10-Dihydr­oxy-13-methyl-13-aza­tetra­cyclo­[9.3.1.02,10.03,8]penta­deca-3(8),4,6-triene-9,15-dione

In the title compound, C15H15NO4, the n-methyl­piperidone ring adopts a chair conformation and both five-membered rings adopt a twist conformation. An intra­molecular O—H⋯O hydrogen bond is observed. Inversion-related mol­ecules are linked into R 2 2(10) dimers by pairs of O—H⋯O hydrogen bonds. The crystal structure is further stabilized by C—H⋯O hydrogen bonds

(E)-1,1,4,4-Tetra­phenyl­but-2-yne-1,4-diol

The mol­ecule of the title compound, C28H22O2, is centrosymmetric with the inversion centre located at the mid-point of the C C bond [1.178 (5) Å]. The hydroxyl groups therefore lie on either side of the mol­ecule. The crystal structure is stabilized by O—H⋯O hydrogen bonds, leading to the formation of a linear supra­molecular chain along the b axis