Safety and efficacy of testosterone gel in the treatment of male hypogonadism

Transdermal testosterone gels were first introduced in the US in 2000. Since then, they have emerged as a favorable mode of testosterone substitution. Serum testosterone levels reach a steady-state in the first 24 hours of application and remain in the normal range for the duration of the application. This pharmacokinetic profile is comparable to that of testosterone patch but superior to injectable testosterone esters that are associated with peaks and troughs with each dose. Testosterone gels are as efficacious as patches and injectable forms in their effects on sexual function and mood. Anticipated increases in prostate-specific antigen with testosterone therapy are not significantly different with testosterone gels, and the risk of polycythemia is lower than injectable modalities. Application site reactions, a major drawback of testosterone patches, occur less frequently with testosterone gels. However, inter-personal transfer is a concern if appropriate precautions are not taken. Superior tolerability and dose flexibility make testosterone gel highly desirable over other modalities of testosterone replacement. Androgel and Testim, the two currently available testosterone gel products in the US, have certain brand-specific properties that clinicians may consider prior to prescribing

Ethyl 2-acetyl-3-(4-bromo­anilino)butanoate

The title compound, C14H18BrNO3, adopts an extended conformation, with all of the main-chain torsion angles associated with the ester and amino groups close to trans. In the crystal, inversion dimers linked by pairs of N—H⋯O hydrogen bonds are observed

Comparative and temporal transcriptome analysis of peste des petits ruminants virus infected goat peripheral blood mononuclear cells

Peste des petits ruminanats virus (PPRV), a morbillivirus causes an acute, highly contagious disease – peste des petits ruminants (PPR), affecting goats and sheep. Sungri/96 vaccine strain is widely used for mass vaccination programs in India against PPR and is considered the most potent vaccine providing long-term immunity. However, occurrence of outbreaks due to emerging PPR viruses may be a challenge. In this study, the temporal dynamics of immune response in goat peripheral blood mononuclear cells (PBMCs) infected with Sungri/96 vaccine virus was investigated by transcriptome analysis. Infected goat PBMCs at 48 h and 120 h post infection revealed 2540 and 2000 differentially expressed genes (DEGs), respectively, on comparison with respective controls. Comparison of the infected samples revealed 1416 DEGs to be altered across time points. Functional analysis of DEGs reflected enrichment of TLR signaling pathways, innate immune response, inflammatory response, positive regulation of signal transduction and cytokine production. The upregulation of innate immune genes during early phase (between 2-5 days) viz. interferon regulatory factors (IRFs), tripartite motifs (TRIM) and several interferon stimulated genes (ISGs) in infected PBMCs and interactome analysis indicated induction of broad-spectrum anti-viral state. Several Transcription factors – IRF3, FOXO3 and SP1 that govern immune regulatory pathways were identified to co-regulate the DEGs. The results from this study, highlighted the involvement of both innate and adaptive immune systems with the enrichment of complement cascade observed at 120 h p.i., suggestive of a link between innate and adaptive immune response. Based on the transcriptome analysis and qRT-PCR validation, an in vitro mechanism for the induction of ISGs by IRFs in an interferon independent manner to trigger a robust immune response was predicted in PPRV infection

Clinical Meaningfulness of the Changes in Muscle Performance and Physical Function Associated With Testosterone Administration in Older Men With Mobility Limitation

Context. Testosterone in Older Men with Mobility Limitations Trial determined the effects of testosterone on muscle performance and physical function in older men with mobility limitation. Trial's Data and Safety Monitoring Board recommended enrollment cessation due to increased frequency of adverse events in testosterone arm. The changes in muscle performance and physical function were evaluated in relation to participant's perception of change. Methods. Men aged 65 years and older, with mobility limitation, total testosterone 100-350 ng/dL, or free testosterone less than 50 pg/mL, were randomized to placebo or 10 g testosterone gel daily for 6 months. Primary outcome was leg-press strength. Secondary outcomes included chest-press strength, stair-climb, 40-m walk, muscle mass, physical activity, self-reported function, and fatigue. Proportions of participants exceeding minimally important difference in study arms were compared. Results. Of 209 randomized participants, 165 had follow-up efficacy measures. Mean (SD) age was 74 (5.4) years and short physical performance battery score 7.7 (1.4). Testosterone arm exhibited greater improvements in leg-press strength, chest-press strength and power, and loaded stair-climb than placebo. Compared with placebo, significantly greater proportion of men receiving testosterone improved their leg-press and chest-press strengths (43% vs 18%, p = .01) and stair-climbing power (28% vs 10%, p = .03) more than minimally important difference. Increases in leg-press strength and stair-climbing power were associated with changes in testosterone levels and muscle mass. Physical activity, walking speed, self-reported function, and fatigue did not change. Conclusions. Testosterone administration in older men with mobility limitation was associated with patient-important improvements in muscle strength and stair-climbing power. Improvements in muscle strength and only some physical function measures should be weighed against the risk of adverse events in this populatio

Effect of Video Games in Learning of Industrial Technology Students

The nonimmigrant international students from all over the world coming to United States of America face difficulty in understanding the vocabulary and English language since they are from different style of teaching environment. International students face difficulty and get stressed in learning the subject as they are brought to them in the traditional U.S. style of teaching which can lead to negative effects like increase in dropout rates and losing interest in studies. The problem is students feel stressed when they are taught with complicated issues in subjects. A possible solution to overcome this issue is by using strategic games in learning like the WORD SPLASH. How and to what extent does using Word Splash a strategic vocabulary word game in academic curriculum enhance the learning ability of international students in industrial technology courses at Pittsburg State University? The problem is that the international students of Industrial Technology at Pittsburg State University face are struggling with the language & vocabulary such as not using correct word or phrase during speaking and writing which resulting either poor communication or losing the grades by submitting the paper with poor vocabulary. Word Splash is a game that can help student improve in learning terminology in comprehension and vocabulary strategy, it is the game which can be played inside the class by having fun among the students. This event also motivates them in order to be attentive in the class to learn more things and to communicate well in the class. The game can be played like before starting a new chapter the new words of it are analyzed and picked by the teacher then words are splashed on the screen of the computer or the sentences whose vocabulary needs to be corrected, then the students have to work on this to correct them when they fit in the right word it gives green tick else they have to try again in the mean they get many suggestions and out comes what can be fit into it. The type of research methodology to be used is qualitative which has the sequence as follow, first by selecting the participants and site like international Industrial technology students at PSU. After qualitative observation of selected participants with their permission, then by formulating the standard research questions from my observation the Qualitative interviews like face to face to the participants will be done with that difficulties can be known by which students are facing due to traditional method of teaching. With the specified questions from above observations and then providing time to play game so that they can feel the difference and take the interviews again to observe the change. Then formulating the documents on all the above process by taking visual materials also into consideration gives proper results to research study by which can be finally concluded.https://digitalcommons.pittstate.edu/posters_2015/1008/thumbnail.jp

Safety and efficacy of testosterone gel in the treatment of male hypogonadism

Kishore M Lakshman, Shehzad BasariaSection of Endocrinology, Diabetes, and Nutrition. Boston University School of Medicine, Boston Medical Center, Boston, MA, USAAbstract: Transdermal testosterone gels were first introduced in the US in 2000. Since then, they have emerged as a favorable mode of testosterone substitution. Serum testosterone levels reach a steady-state in the first 24 hours of application and remain in the normal range for the duration of the application. This pharmacokinetic profile is comparable to that of testosterone patch but superior to injectable testosterone esters that are associated with peaks and troughs with each dose. Testosterone gels are as efficacious as patches and injectable forms in their effects on sexual function and mood. Anticipated increases in prostate-specific antigen with testosterone therapy are not significantly different with testosterone gels, and the risk of polycythemia is lower than injectable modalities. Application site reactions, a major drawback of testosterone patches, occur less frequently with testosterone gels. However, inter-personal transfer is a concern if appropriate precautions are not taken. Superior tolerability and dose flexibility make testosterone gel highly desirable over other modalities of testosterone replacement. Androgel and Testim, the two currently available testosterone gel products in the US, have certain brandspecific properties that clinicians may consider prior to prescribing.Keywords: testosterone gel, Androgel, Testim, hypogonadis

Microbiological analysis of oral samples for detection of Mycobacterium tuberculosis by nested polymerase chain reaction in tuberculosis patients with periodontitis

Background: Due to high prevalence of tuberculosis (TB) in India, presence of Mycobacterium tuberculosis in oral samples might influence the periodontal status of patients and also might pose a risk of transmission of TB during dental procedures through aerosols. Hence, this study aims to compare the periodontal status between TB and non-TB patients and to detect the presence of M. tuberculosis in plaque and saliva of TB and non-TB patients. Materials and Methods: A total of 25 TB and 25 non-TB systemically healthy patients (age 21-49 years) were selected for this Clinico-Microbiological study. The oral hygiene and periodontal status of the patients were measured by using clinical indices and were compared using Mann-Whitney test ( P < 0.05 = Significant). Pooled plaque and unstimulated salivary samples were collected and subjected to microbiological evaluation of M. tuberculosis by nested polymerase chain reaction. The detection rates were compared using Chi-square test ( P < 0.001 = Highly significant). Results: No significant difference was observed in periodontal clinical parameters measured between the groups. M. tuberculosis was detected in 92% of saliva and 68% of plaque samples of tuberculosis group, and even in 12% of saliva samples in nontuberculosis group patients. Conclusion: The TB status of the patient did not influence the periodontal status. However, the presence of M. tuberculosis in plaque and saliva as detected in this study might pose a grave risk of transmission of the disease through aerosols during dental procedures

A Single-Layer S/X- Band Shared Aperture Antenna with MIMO Characteristics at X-Band for Airborne Synthetic Aperture Radar Applications

New frequencies can be supported with very effective space use by using the shared aperture antenna This work presents on designing a dual-banddual-polarized (DBDP) S/X-band shared aperture antenna (SAA) for synthetic aperture radar (SAR) applications operating at S-band frequency (3.2 GHz) and X-band frequency (9.65 GHz). The single-layer SAA DBDP S-band antenna is designed in a square-shaped patch with coaxial feeding in both vertical and horizontal polarization. The X-band antenna design is in 1 × 3 vertical series with microstrip feeding and arranged at four corners of the proposed antenna. The S-band antenna is mainly used for airborne applications such as air traffic control and surface ship radar. In contrast, the X-band antenna application is maritime vessel traffic control, defense tracking, and vehicle speed detection for law enforcement. To verify the antenna, a prototype is fabricated and measured with s-parameters. The proposed design exhibits that the gain of the S-band is 7.2 dB and for the X-band is 12.4 dB, and the isolation is achieved more than −35 dB, and for this antenna, we achieved a bandwidth of 0.12 GHz for S-band and 0.27 GHz for X-band. However, the X-band antenna is a multi-input and multioutput antenna that is to be validated by using MIMO characteristic parameters such as envelope correlation coefficient (ECC), diversity gain (DG), channel capacity loss (CCL), mean effective gain, and mutual coupling. The MIMO characteristic parameter of X-band antenna values is found to be in a similar manner to both simulated and measured values. For this X-Band antenna, ECC, DG, CCL, and mutual coupling were achieved as below 0.05, 9.5 dB, 0.5 bps/Hz, and −30 dB to −55 dB, respectively. The total size of the antenna is 100 mm × 100 mm × 1.6 mm

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Not AvailableWhite mold commonly known as Sclerotinia sclerotiorum causes stem rot disease and has emerged as one of the major fungal pathogens of oilseed Brassica across the world. In the present study, consistently virulent S. sclerotiorum isolate “ESR-01” was sequenced and an assembly size of ~ 41 Mb with 328 scaffolds having N50 of 447,128 was obtained. Additionally, 27,450 single nucleotide polymorphisms (SNPs) were identified from 155 scaffolds against S. sclerotiorum 1980 isolate, with an average SNP density of ~ 1.5 per kb genome. 667 repetitive elements were identified and approximately comprised 7% of the total annotated genes. The DDE_1 with 454 in numbers was found to be the most abundant and accounts for 68% of the total predicted repetitive elements. In total, 3844 simple sequence repeats are identified in the 328 scaffolds. A total of 9469 protein-coding genes were predicted from the whole genome assembly with an average gene length of 1587 bp and their distribution as 230.95 genes per Mb in the genome. Out of 9469 predicted protein-coding genes, 529 genes were observed encoding the CAZymes (Carbohydrate-Active enzymes) capable of degradation of the complex polysaccharides. Glycosyltransferase (GT) families were most abundant (49.71%) among the predicted CAZymes and GT2 (23%), GT4 (20%), and glycoside hydrolase (GH) 23% with GH18 (11%) were the prominent cell wall degrading enzyme families in the ESR-01 secretome. Besides this, 156 genes essential for the pathogen-host interactions were also identified. The effector analysis in the whole genome proteomics dataset revealed a total of 57 effector candidates (ECs) and 27 of them were having their analogs whereas the remaining 30 were novel ones. Eleven selected ECs were validated experimentally by analyzing the expression profile of the ESR-01 isolate of S. sclerotiorum. Together, the present investigation offers a better understanding of the S. sclerotiorum genome, secretome, and its effector repertoire which will help in refining the present knowledge on S. sclerotiorum-Brassica interactions and necrotrophic lifestyle of the phytopathogen in general.Not Availabl