Nova vrsta špiljskoga roda Machaerites Miller, 1855 (Coleoptera, Staphylinidae, Pselaphinae) iz Hrvatske

Machaerites udrzali sp. nov., a new cavernicolous species of the tribe Bythinini from Croatia, Plitvice, Rodićeva pećina is described and illustrated; the systematic position of the species is discussed.U radu se opisuje nova špiljska vrsta Machaerites udrzali sp. nov. iz skupine Bythinini iz Hrvatske (Plitvice, Rodićeva pećina); raspravlja se o položaju vrste u sistematici

Treatment of metastatic head and neck cancer with mesenchymal stem cells combined with prodrug gene therapy

This is a clinical observation of a patient treated for metastatic head and neck cancer with mesenchymal stem cells mediated prodrug gene therapy. The cells were applied intravenously. We did not observe any therapeutic effect. However, a temporal bicytopenia was observed. Key Words: metastatic head and neck cancer, therapeutic stem cells, blood counts

Lovricia aenigmatica – nova vrsta troglobiontskog kornjaša iz Hrvatske (Coleoptera: Carabidae)

Lovricia aenigmatica, n. sp., a highly specialized troglobitic carabid beetle from a nameless 51 m deep pit in the Biokovo Mts. (Croatia, Middle Dalmatia) is described, illustrated and compared with the related species Lovricia jalzici Pretner, 1979.Rad donosi opis i crtež visokospecijalizirane vrste troglobiontskog kornjaša Lovricia aenigmatica iz 51 m duboke jame na Biokovu (Hrvatska, središnja Dalmacija). Vrsta se uspoređuje s L. jalzici Pretner, 1979

ICIRAS: Research and reconciliation with indigenous peoples in rural health journals.

AIM: We aim to promote discussion about an Indigenous Cultural Identity of Research Authors Standard (ICIRAS) for academic journal publications. CONTEXT: This is based on a gap in research publishing practice where Indigenous peoples' identity is not systematically and rigorously flagged in rural health research publications. There are widespread reforms, in different research areas, to counter the reputation of scientific research as a vehicle of racism and discrimination against the world's Indigenous peoples. Reflecting on these broader movements, the editorial teams of three rural health journals-the Australian Journal of Rural Health, the Canadian Journal of Rural Medicine, and Rural and Remote Health-recognised that Indigenous peoples' identity could be embedded in authorship details. APPROACH: An environmental scan (through a cultural safety lens where Indigenous cultural authority is respected, valued, and empowered) of literature was undertaken to detect the signs of inclusion of Indigenous peoples in research. This revealed many ways in which editorial boards of Journals could systematically improve their process so that there is 'nothing about Indigenous people, without Indigenous people' in rural health research publications. CONCLUSION: Improving the health and wellbeing of Indigenous peoples worldwide requires high quality research evidence. The philosophy of cultural safety supports the purposeful positioning of Indigenous peoples within the kaleidoscope of cultural knowledges as identified contributors and authors of research evidence. The ICIRAS is a call-to-action for research journals and institutions to rigorously improve publication governance that signals "Editing with IndigenUs and for IndigenUs"

Nova vrsta špiljskoga roda Machaerites Miller, 1855 (Coleoptera, Staphylinidae, Pselaphinae) iz Hrvatske

Machaerites udrzali sp. nov., a new cavernicolous species of the tribe Bythinini from Croatia, Plitvice, Rodićeva pećina is described and illustrated; the systematic position of the species is discussed.U radu se opisuje nova špiljska vrsta Machaerites udrzali sp. nov. iz skupine Bythinini iz Hrvatske (Plitvice, Rodićeva pećina); raspravlja se o položaju vrste u sistematici

Antibodies against carbonic anhydrase in patients with aplastic anemia

BACKGROUND/AIMS: Antibodies against carbonic anhydrase (CA) have been detected in patients with an aplastic anemia (AA)-like syndrome after autologous stem cell transplantation. METHODS: We analyzed sera of 53 bona fide AA patients before and after treatment with anti-thymocyte globulin (ATG) or bone marrow transplantation for the presence of anti-CA antibodies. RESULTS: Anti-CA antibodies were detected in 20 patients (38%) and were associated with older age at diagnosis of AA. Antibody-positive patients showed poor response to ATG treatment (complete response 14%) and inferior long-term survival (36% at 10 years), when compared to antibody-negative patients (complete response and 10-year survival both 64%). Two thirds of patients with antibodies at diagnosis of AA became antibody negative after treatment with ATG. Clearance of the antibody did not appear to be associated with hematological improvement. CONCLUSION: Antibodies against CA are detected frequently at diagnosis of AA, and their presence identifies a subset of patients with poor response to immunosuppressive treatment

A significance of additional chromosomal aberrations and other variables on post transplantation outcome of patients with CML

Chronic myeloic leukemia (CML) is a malignant disease of hematopoietic stem cell characterized by the bcr/abl gene rearrangement. Allogeneic transplantation of stem cells (SCT) is a routinely used treatment method of patients with this diagnosis and remains the only curative mode of treatment. From January 1990 to December 2002, 78 patients with CML underwent allogeneic transplantation and were examined at the Department of Genetics in the National Cancer Institute in Bratislava. Using conventional cytogenetic and FISH 6 patients (7.7%) showed additional chromosomal changes before SCT. These patients had statistically worse post transplantation prognosis compared to the patients without additional changes before SCT (mean survival in month+/-standard error (58.08 (+/-6.70) vs. 5.17 (+/-0.98), p-value=0.001), patient mortality (67% vs. 31%)). In addition five other variables were evaluated for transplant outcome, namely, patient's age at the time of transplantation, sibling or non-sibling donor, higher than 1st chronic phase CML, time from diagnosis to transplantation and sex of donor and recipient. Only the comparison of HLA-identical sibling transplantation to unrelated donor transplantation was statistically significant (mean survival in month- 56.6 (+/-7.2) vs. 13 (+/-0.0), patient mortality 31% vs. 67%)