Properties of ceria films grown on stainless steel by electrodeposition method

The study focuses on the elaboration of thin nanostructured ceria films, grown on the stainless steel, in view of high temperature fuel cell applications. Films were prepared electrochemically, via cathodic electrolytic deposition method, at low temperature (30 0C). Structural, morphological and composition analysis of the asgrown and annealed films were performed by means of XRD, Raman, SEM and EDX measurements

Bioinformatics for precision medicine in oncology: principles and application to the SHIVA clinical trial

Precision medicine (PM) requires the delivery of individually adapted medical care based on the genetic characteristics of each patient and his/her tumor. The last decade witnessed the development of high-throughput technologies such as microarrays and next-generation sequencing which paved the way to PM in the field of oncology. While the cost of these technologies decreases, we are facing an exponential increase in the amount of data produced. Our ability to use this information in daily practice relies strongly on the availability of an efficient bioinformatics system that assists in the translation of knowledge from the bench towards molecular targeting and diagnosis. Clinical trials and routine diagnoses constitute different approaches, both requiring a strong bioinformatics environment capable of (i) warranting the integration and the traceability of data, (ii) ensuring the correct processing and analyses of genomic data, and (iii) applying well-defined and reproducible procedures for workflow management and decision-making. To address the issues, a seamless information system was developed at Institut Curie which facilitates the data integration and tracks in real-time the processing of individual samples. Moreover, computational pipelines were developed to identify reliably genomic alterations and mutations from the molecular profiles of each patient. After a rigorous quality control, a meaningful report is delivered to the clinicians and biologists for the therapeutic decision. The complete bioinformatics environment and the key points of its implementation are presented in the context of the SHIVA clinical trial, a multicentric randomized phase II trial comparing targeted therapy based on tumor molecular profiling versus conventional therapy in patients with refractory cancer. The numerous challenges faced in practice during the setting up and the conduct of this trial are discussed as an illustration of PM application

The RD-Connect Genome-Phenome Analysis Platform: Accelerating diagnosis, research, and gene discovery for rare diseases.

Rare disease patients are more likely to receive a rapid molecular diagnosis nowadays thanks to the wide adoption of next-generation sequencing. However, many cases remain undiagnosed even after exome or genome analysis, because the methods used missed the molecular cause in a known gene, or a novel causative gene could not be identified and/or confirmed. To address these challenges, the RD-Connect Genome-Phenome Analysis Platform (GPAP) facilitates the collation, discovery, sharing, and analysis of standardized genome-phenome data within a collaborative environment. Authorized clinicians and researchers submit pseudonymised phenotypic profiles encoded using the Human Phenotype Ontology, and raw genomic data which is processed through a standardized pipeline. After an optional embargo period, the data are shared with other platform users, with the objective that similar cases in the system and queries from peers may help diagnose the case. Additionally, the platform enables bidirectional discovery of similar cases in other databases from the Matchmaker Exchange network. To facilitate genome-phenome analysis and interpretation by clinical researchers, the RD-Connect GPAP provides a powerful user-friendly interface and leverages tens of information sources. As a result, the resource has already helped diagnose hundreds of rare disease patients and discover new disease causing genes

Organisation et agrégats dans les sels fondus à température ambiante (relations structure/réactivité)

PARIS-BIUSJ-Thèses (751052125) / SudocPARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF

Influence of pressure on the electrical and electrochemical behaviour of high-temperature steam electrolyser La0.6Sr0.4Co0.2Fe0.8O3 anode

International audienc

Electrochemical synthesis and characterization of nanorods, nanocolumnar ceria based thin films on different glass substrates

Nanorods, nanocolumnar-based ceria thin films were electrodeposited onto (FTO) or (ITO) glass substrates, at room temperature. Cubic fluorite type ceria nanostructured films of high crystal quality were synthesized on both substrates, as confirmed by X-ray diffraction and Raman spectroscopy. It was found that a substrate is a structure-directing agent for the growth process of ceria. Columnar-like particles were grown on ITO, and a rod-like ceria on the FTO substrate. It was shown that, by selecting type of the conductive film on glass substrate and cleaning procedure, one-dimensional (1-D) rod-like ceria structures can grow on the FTO-covered substrate, by electrodeposition. (C) 2010 Elsevier B. V. All rights reserved

Mixtures of room temperature ionic liquid/ethanol solutions as electrolytic media for cerium oxide thin layer electrodeposition

International audienceA cerium oxide thin layer was electrodeposited onto stainless steel, using mixed room temperature ionic liquid (the 1-methyl-3-butylimidazolium bis(trifluoromethyl sulfonyl)imide)/ethanol solutions, as electrolytic medium. The hydrophobic ionic liquid content is one of the main parameters in the morphology control influencing the ceria growth rate and crystallinity. Micro-nano structural properties and electrical behaviour are presented, using XRD, SEM/EDS and impedance spectroscopy, as a function of electrodeposition conditions