Pattern of infection in children presented with obstructive uropathy: A hospital-based study

Background: Obstructive uropathy refers to the structural impedance to the flow of urine anywhere along the urinary tract which may result from congenital (anatomic) lesions or can be caused by trauma, neoplasia, calculi, inflatnmatory process or surgical procedure. It is responsible for about 4% of end-stage renal disease. Obstructive uropathy is invariably associated with some co-morbid conditions specially infection.Objecctive: This study was conducted in the department of pediatric nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, Bangladesh with an objective to identify different pattern of infections in children with obstructive uropathy. Methods: A total of 55 patients of obstructive uropathy were enrolled. Thorough clinical and laboratory evaluation including hematological, biochemical, radiological and radio nucleotide imaging were done along with blood and urine culture. Result: Out of 55 cases, 42.27% of obstructive uropathy was detected between I to 5 years and 89.27% was infected. Among obstructive uropathy cases, majority had posterior urethral valve (PUV) (42.27%). Urinary tract infection was the commonest (60%) type of infections followed by septicemia and respiratory tract infection. Conclusion: Age between 1 to 5 years was the commonest age of children for hospital admission due to obstructive uropathy. Among various manifestations of obstruc­tive uropatby, infections, mostly urinary tract infection was the commonest one

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Pattern of infection in children presented with obstructive uropathy: A hospital-based study

Background: Obstructive uropathy refers to the structural impedance to the flow of urine anywhere along the urinary tract which may result from congenital (anatomic) lesions or can be caused by trauma, neoplasia, calculi, inflatnmatory process or surgical procedure. It is responsible for about 4% of end-stage renal disease. Obstructive uropathy is invariably associated with some co-morbid conditions specially infection. Objecctive: This study was conducted in the department of pediatric nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, Bangladesh with an objective to identify different pattern of infections in children with obstructive uropathy. Methods: A total of 55 patients of obstructive uropathy were enrolled. Thorough clinical and laboratory evaluation including hematological, biochemical, radiological and radio nucleotide imaging were done along with blood and urine culture. Result: Out of 55 cases, 42.27% of obstructive uropathy was detected between I to 5 years and 89.27% was infected. Among obstructive uropathy cases, majority had posterior urethral valve (PUV) (42.27%). Urinary tract infection was the commonest (60%) type of infections followed by septicemia and respiratory tract infection. Conclusion: Age between 1 to 5 years was the commonest age of children for hospital admission due to obstructive uropathy. Among various manifestations of obstruc­tive uropatby, infections, mostly urinary tract infection was the commonest one

The HyperPed-COVID international registry: Impact of age of onset, disease presentation and geographical distribution on the final outcome of MIS-C

Objectives: The aim of the study was to establish an international multicenter registry to collect data on patients with Multisystem Inflammatory Syndrome in Children (MIS-C), in order to highlight a relationship between clinical presentation, age of onset and geographical distribution on the clinical outcome. Study design: Multicenter retrospective study involving different international societies for rare immunological disorders.1009 patients diagnosed with MIS-C between March and September 2022, from 48 centers and 22 countries were collected. Five age groups (<1, 1-4, 5-11, 12-16, >16 years) and four geographic macro-areas, Western Europe, Central-Eastern Europe, Latin America, Asian-African resource-limited countries (LRC), were identified. Results: Time to referral was significantly higher in LRC. Intensive anti-inflammatory treatment, including biologics, respiratory support and mechanic ventilation were more frequently used in older children and in European countries. The mortality rate was higher in very young children (<1 year), in older patients (>16 years of age) and in LRC. Multivariate analysis identified the residence in LRC, presence of severe cardiac involvement, renal hypertension, lymphopenia and non-use of heparin prophylaxis, as the factors most strongly associated with unfavorable outcomes. Conclusions: The stratification of patients by age and geographic macro-area provided insights into the clinical presentation, treatment and outcome of MIS-C. The mortality and sequelae rates exhibited a correlation with the age and geographical areas. Patients admitted and treated in LRC displayed more severe outcomes, possibly due to delays in hospital admission and limited access to biologic drugs and to intensive care facilities

COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.</p