Modeling of the IC\u27s Switching Currents on the Power Bus of a High Speed Digital Board

When the performances of the electronic technology increase (higher frequencies, more power, lover power supply, faster transistors, reduced chip dimensions), designing electronic equipment becomes more challenging for the electronic engineers. Signal and power integrity on board become of paramount importance. One of the main causes of board malfunctions and electromagnetic radiation is the simultaneous switching noise (SSN) due to the integrated circuits soldered on the board. The paper proposes two simple procedures to model the SSN, so to evaluate its effects in any point of the board

Studio preliminare sulla struttura genetica di <i>Patella ferruginea</i> Gmelin, 1791 (Mollusca, Gastropoda), nell'Area Marina Protetta (AMP) dell'Isola dell'Asinara mediante ISSR

L'istituzione delle AMP consente adeguate misure di conservazione dell'ambiente marino. L'efficacia di tale protezione dovrebbe essere verificata attraverso programmi di monitoraggio, utilizzando specie che siano facili da identificare e analizzare in modo non distruttivo. In tale contesto è stata individuata Patella ferruginea, che risulta essere l'invertebrato marino più minacciato del Mediterraneo occidentale. L'obiettivo dello studio è quello di stimare i livelli di diversità genetica e flusso genico di alcune popolazioni di P. ferruginea dell'AMP dell'Isola dell'Asinara. È stato prelevato il materiale biologico di 10 esemplari da 3 diversi siti, tramite escissione di piccole quantità di tessuto muscolare, seguendo un protocollo da noi sperimentato sulla specie P. ulyssiponensis. Il protocollo assicura la sopravvivenza degli esemplari campionati. L'analisi genetica è stata condotta attraverso la genotipizzazione di un subcampione di individui per ciascun sito utilizzando la tecnica ISSR (Inter-Simple Sequence Repeat). I risultati indicano una notevole uniformità genetica tra gli individui appartenenti a ciascun sito, contrapposta ad una moderata eterogeneità genetica tra gli individui appartenenti ai tre siti. Questi fatti suggeriscono inoltre che P. ferruginea possa aver subito erosione genetica negli anni passati in relazione alla sua raccolta, e che i livelli di flusso genico non siano elevati anche su piccola scala geografica

Therapist reactions to patient personality: A pilot study of clinicians’ emotional and neural responses using three clinical vignettes from "In Treatment" series

Introduction: Therapists’ responses to patients play a crucial role in psychotherapy and are considered a key component of the patient–clinician relationship, which promotes successful treatment outcomes. To date, no empirical research has ever investigated therapist response patterns to patients with different personality disorders from a neuroscience perspective. Methods: In the present study, psychodynamic therapists (N = 14) were asked to complete a battery of instruments (including the Therapist Response Questionnaire) after watching three videos showing clinical interactions between a therapist and three patients with narcissistic, histrionic/borderline, and depressive personality disorders, respectively. Subsequently, participants’ high-density electroencephalography (hdEEG) was recorded as they passively viewed pictures of the patients’ faces, which were selected from the still images of the previously shown videos. Supervised machine learning (ML) was used to evaluate whether: (1) therapists’ responses predicted which patient they observed during the EEG task and whether specific clinician reactions were involved in distinguishing between patients with different personality disorders (using pairwise comparisons); and (2) therapists’ event-related potentials (ERPs) predicted which patient they observed during the laboratory experiment and whether distinct ERP components allowed this forecast. Results: The results indicated that therapists showed distinct patterns of criticized/devalued and sexualized reactions to visual depictions of patients with different personality disorders, at statistically systematic and clinically meaningful levels. Moreover, therapists’ late positive potentials (LPPs) in the hippocampus were able to determine which patient they observed during the EEG task, with high accuracy. Discussion: These results, albeit preliminary, shed light on the role played by therapists’ memory processes in psychotherapy. Clinical and neuroscience implications of the empirical investigation of therapist responses are discussed

Problems Associated With the Assessment of Local Site Effects Through a Multidisciplinary Integrated Study: The Case of Fivizzano’s Town (Italy)

The evaluation of local site effects, by means of ground response analyses, is a very complex and difficult task, which requires a multidisciplinary approach. This is operative philosophy expressed by VEL Project (Valutazione degli Effetti Locali), sponsored by Tuscany Region, to the aim to seismic risk characterization in the main seismic areas (i.e. Garfagnana, Lunigiana, Amiata, Valtiberina and Mugello). One of the most important urban centres, involved in the multidisciplinary activity of the VEL project, is certainly the town of Fivizzano located nearby the city of Massa, which was strongly damaged during the earthquake of September 1920 (the strongest seismic event occurred in Northern Apennines in the latest centuries). Remarkably good macroseismic information is available about the destructive impact yielded at Fivizzano by this earthquake (e.g. number of casualties, level of damage of buildings, etc). The main objective of this paper is to identify the occurrence of possible local site effects in the Fivizzano’s area following the 1920 earthquake and to quantify them by means of one and two-dimensional site response analysis. The input data required for study were obtained through a comprehensive geological survey and a multi disciplinary underground exploration of the area

Evidence of potential bias in a comparison of beta blockers and calcium channel blockers in patients with chronic obstructive pulmonary disease and acute coronary syndrome: results of a multinational study

OBJECTIVES: A number of observational studies have reported that, in patients with chronic obstructive pulmonary disease (COPD), beta blockers (BBs) decrease risk of mortality and COPD exacerbations. To address important methodological concerns of these studies, we compared the effectiveness and safety of cardioselective BBs versus non-dihydropyridine calcium channel blockers (non-DHP CCBs) in patients with COPD and acute coronary syndromes (ACS) using a propensity score (PS)-matched, active comparator, new user design. We also assessed for potential unmeasured confounding by examining a short-term COPD hospitalisation outcome. SETTING AND PARTICIPANTS: We identified 22 985 patients with COPD and ACS starting cardioselective BBs or non-DHP CCBs across 5 claims databases from the USA, Italy and Taiwan. PRIMARY AND SECONDARY OUTCOME MEASURES: Stratified Cox regression models were used to estimate HRs for mortality, cardiovascular (CV) hospitalisations and COPD hospitalisations in each database after variable-ratio PS matching. Results were combined with random-effects meta-analyses. RESULTS: Cardioselective BBs were not associated with reduced risk of mortality (HR, 0.90; 95% CI 0.78 to 1.02) or CV hospitalisations (HR, 1.06; 95% CI 0.91 to 1.23), although statistical heterogeneity was observed across databases. In contrast, a consistent, inverse association for COPD hospitalisations was identified across databases (HR, 0.54; 95% CI 0.47 to 0.61), which persisted even within the first 30 days of follow-up (HR, 0.55; 95% CI 0.37 to 0.82). Results were similar across a variety of sensitivity analyses, including PS trimming, high dimensional-PS matching and restricting to high-risk patients. CONCLUSIONS: This multinational study found a large inverse association between cardioselective BBs and short-term COPD hospitalisations. The persistence of this bias despite state-of-the-art pharmacoepidemiologic methods calls into question the ability of claims data to address confounding in studies of BBs in patients with COPD

Chapter “Flex 2018” Cruise: an opportunity to assess phytoplankton chlorophyll fluorescence retrieval at different observative scales

The “FLEX 2018” cruise, organized by the CNR-ISMAR in frame of the ESA “FLEXSense Campaign 2018” and CMEMS project, provided a ground station for several bio-optical instruments that investigated the coastal waters of the Tyrrhenian Sea in June 2018. The field measurements were performed in time synergy with Sentinel 3A and Sentinel 3B satellites and HyPlant airborne imaging spectrometer. Active and passive fluorescence were investigated at different scales in coastal waters to support preparatory activities of the FLuorescence EXplorer (FLEX) satellite mission

A Survey on the milk fatty acid composition of forty dairy sheep flocks in Sardinia

A survey was carried out to monitor milk fatty acid (FA) composition during two years (2003 and 2004) on forty dairy sheep flocks, fed pasture based rations, in 5 macro pedoclimatic areas of Sardinia, featured by different i) soil type, (granitic, G; basaltic, B and alluvial, A) ii) average annual rainfall (low, L, 500-600 mm/year; high, H, 600-800 mm/year). Milk FA profile was strongly influenced by year. In particular milk linolenic acid (LN), CLA (conjugated linoeic acid) and PUFA (polyunsaturated fatty acids) levels increased (by 25, 30 and 14%, respectively, P&lt;0.01) whereas the atherogenicity index (AI) decreased (by 8%, P&lt;0.01) in all areas in 2004 as compared with 2003. Pedoclimatic area affected milk fatty acid composition (P&lt;0.01). In both years milk from AL farms showed the highest levels of LN, CLA and PUFA. AI was lower in BH and GH in year 2003 and in BH, AH and GL in 2004

Modeling the contribution of male testosterone levels to the duration of positive COVID testing among hospitalized male COVID-19 patients

Background: A growing body of evidence is emerging suggesting testosterone can affect all cells involved in the immune response to both bacterial and viral infections, and the testosterone effect on the immune response could explain the greater susceptibility of men to infections including COVID-19. We aimed to explore the predictive role of male serum total testosterone (TT) levels on the time till viral negativity testing among hospitalized COVID-19 patients. Methods: The univariate effect of risk factors for the duration of COVID-19 viral positivity was evaluated using the log-rank test and Kaplan-Meier estimates. A multivariable Cox regression model was developed to test the role of TT levels and the subsequent odds for shorter viral positivity intervals. Results: Increasing serum TT levels and the need for an oxygen administration strategy were independently predictive for respectively reduced and increased days to negativization (Hazard Ratio [HR]: 1.39, 95% CI: 0.95-2.03 and HR: 0.19, 95% CI: 0.03-1.18). Conclusion: Baseline higher TT levels for male COVID-19 patients at hospital admission are associated with shorter durations of positive COVID-19 testing and thus viral clearance. Our preliminary findings might play a relevant to help pandemic control strategies if these will be verified in future larger multicentric and possibly randomized trials

GRIDA3—a shared resources manager for environmental data analysis and applications

GRIDA3 (Shared Resources Manager for Environmental Data Analysis and Applications) is a multidisciplinary project designed to deliver an integrated system to forge solutions to some environmental challenges such as the constant increase of polluted sites, the sustainability of natural resources usage and the forecast of extreme meteorological events. The GRIDA3 portal is mainly based on Web 2.0 technologies and EnginFrame framework. The portal, now at an advanced stage of development, provides end-users with intuitive Web-interfaces and tools that simplify job submission to the underneath computing resources. The framework manages the user authentication and authorization, then controls the action and job execution into the grid computing environment, collects the results and transforms them into an useful format on the client side. The GRIDA3 Portal framework will provide a problem-solving platform allowing, through appropriate access policies, the integration and the sharing of skills, resources and tools located at multiple sites across federated domains