2,181 research outputs found
Stretching and squeezing of sessile dielectric drops by the optical radiation pressure
We study numerically the deformation of sessile dielectric drops immersed in
a second fluid when submitted to the optical radiation pressure of a continuous
Gaussian laser wave. Both drop stretching and drop squeezing are investigated
at steady state where capillary effects balance the optical radiation pressure.
A boundary integral method is implemented to solve the axisymmetric Stokes flow
in the two fluids. In the stretching case, we find that the drop shape goes
from prolate to near-conical for increasing optical radiation pressure whatever
the drop to beam radius ratio and the refractive index contrast between the two
fluids. The semi-angle of the cone at equilibrium decreases with the drop to
beam radius ratio and is weakly influenced by the index contrast. Above a
threshold value of the radiation pressure, these "optical cones" become
unstable and a disruption is observed. Conversely, when optically squeezed, the
drop shifts from an oblate to a concave shape leading to the formation of a
stable "optical torus". These findings extend the electrohydrodynamics approach
of drop deformation to the much less investigated "optical domain" and reveal
the openings offered by laser waves to actively manipulate droplets at the
micrometer scale
In-vivo heterogeneous functional and residual strains in human aortic valve leaflets
Residual and physiological functional strains in soft tissues are known to play an important role in modulating organ stress distributions. Yet, no known comprehensive information on residual strains exist, or non-invasive techniques to quantify in-vivo deformations for the aortic valve (AV) leaflets. Herein we present a completely non-invasive approach for determining heterogeneous strains – both functional and residual – in semilunar valves and apply it to normal human AV leaflets. Transesophageal 3D echocardiographic (3DE) images of the AV were acquired from open-heart transplant patients, with each AV leaflet excised after heart explant and then imaged in a flattened configuration ex-vivo. Using an established spline parameterization of both 3DE segmentations and digitized ex-vivo images (Aggarwal et al., 2014), surface strains were calculated for deformation between the ex-vivo and three in-vivo configurations: fully open, just-coapted, and fully-loaded. Results indicated that leaflet area increased by an average of 20% from the ex-vivo to in-vivo open states, with a highly heterogeneous strain field. The increase in area from open to just-coapted state was the highest at an average of 25%, while that from just-coapted to fully-loaded remained almost unaltered. Going from the ex-vivo to in-vivo mid-systole configurations, the leaflet area near the basal attachment shrank slightly, whereas the free edge expanded by ~10%. This was accompanied by a 10° −20° shear along the circumferential-radial direction. Moreover, the principal stretches aligned approximately with the circumferential and radial directions for all cases, with the highest stretch being along the radial direction. Collectively, these results indicated that even though the AV did not support any measurable pressure gradient in the just-coapted state, the leaflets were significantly pre-strained with respect to the excised state. Furthermore, the collagen fibers of the leaflet were almost fully recruited in the just-coapted state, making the leaflet very stiff with marginal deformation under full pressure. Lastly, the deformation was always higher in the radial direction and lower along the circumferential one, the latter direction made stiffer by the preferential alignment of collagen fibers. These results provide significant insight into the distribution of residual strains and the in-vivo strains encountered during valve opening and closing in AV leaflets, and will form an important component of the tool that can evaluate valve׳s functional properties in a non-invasive manner
Regulated dicing of pre-mir-144 via reshaping of its terminal loop.
Although the route to generate microRNAs (miRNAs) is often depicted as a linear series of sequential and constitutive cleavages, we now appreciate multiple alternative pathways as well as diverse strategies to modulate their processing and function. Here, we identify an unusually profound regulatory role of conserved loop sequences in vertebrate pre-mir-144, which are essential for its cleavage by the Dicer RNase III enzyme in human and zebrafish models. Our data indicate that pre-mir-144 dicing is positively regulated via its terminal loop, and involves the ILF3 complex (NF90 and its partner NF45/ILF2). We provide further evidence that this regulatory switch involves reshaping of the pre-mir-144 apical loop into a structure that is appropriate for Dicer cleavage. In light of our recent findings that mir-144 promotes the nuclear biogenesis of its neighbor mir-451, these data extend the complex hierarchy of nuclear and cytoplasmic regulatory events that can control the maturation of clustered miRNAs
Binary-induced collapse of a compact, collisionless cluster
We improve and extend Shapiro's model of a relativistic, compact object which
is stable in isolation but is driven dynamically unstable by the tidal field of
a binary companion. Our compact object consists of a dense swarm of test
particles moving in randomly-oriented, initially circular, relativistic orbits
about a nonrotating black hole. The binary companion is a distant, slowly
inspiraling point mass. The tidal field of the companion is treated as a small
perturbation on the background Schwarzschild geometry near the hole; the
resulting metric is determined by solving the perturbation equations of Regge
and Wheeler and Zerilli in the quasi-static limit. The perturbed spacetime
supports Bekenstein's conjecture that the horizon area of a near-equilibrium
black hole is an adiabatic invariant. We follow the evolution of the system and
confirm that gravitational collapse can be induced in a compact collisionless
cluster by the tidal field of a binary companion.Comment: 9 Latex pages, 14 postscript figure
Long-term field metal extraction by pelargonium:phytoextraction efficiency in relation to plant maturity
The long length of periods required for effective soil remediation via phytoextraction constitutes a weak point that reduces its industrial use. However, these calculated periods are mainly based on short-term and/or hydroponic controlled experiments. Moreover, only a few studies concern more than one metal, although soils are scarcely polluted by only one element.In this scientific context, the phytoextraction of metals and metalloids (Pb, Cd, Zn, Cu,and As) by Pelargonium was measured after a long-term field experiment. Both bulk and rhizosphere soils were analyzed in order to determine the mechanisms involved in soil-root transfer. First, a strong increase in lead phytoextraction was observed with plant maturity, significantly reducing the length of the period required for remediation. Rhizosphere Pb, Zn, Cu, Cd, and As accumulation was observed (compared to bulk soil), indicating metal mobilization by the plant, perhaps in relation to root activity. Moreover, metal phytoextraction and translocation were found to be a function of the metals’ nature. These results, taken altogether, suggest that Pelargonium could be used as a multi-metal hyperaccumulator under multi-metal soil contamination conditions, and they also provide an interesting insight for improving field phytoextraction remediation in terms of the length of time required, promoting this biological technique
Quasiequilibrium sequences of synchronized and irrotational binary neutron stars in general relativity. I. Method and tests
We present a numerical method to compute quasiequilibrium configurations of
close binary neutron stars in the pre-coalescing stage. A hydrodynamical
treatment is performed under the assumption that the flow is either rigidly
rotating or irrotational. The latter state is technically more complicated to
treat than the former one (synchronized binary), but is expected to represent
fairly well the late evolutionary stages of a binary neutron star system. As
regards the gravitational field, an approximation of general relativity is
used, which amounts to solving five of the ten Einstein equations (conformally
flat spatial metric). The obtained system of partial differential equations is
solved by means of a multi-domain spectral method. Two spherical coordinate
systems are introduced, one centered on each star; this results in a precise
description of the stellar interiors. Thanks to the multi-domain approach, this
high precision is extended to the strong field regions. The computational
domain covers the whole space so that exact boundary conditions are set to
infinity. Extensive tests of the numerical code are performed, including
comparisons with recent analytical solutions. Finally a constant baryon number
sequence (evolutionary sequence) is presented in details for a polytropic
equation of state with gamma=2.Comment: Minor corrections, references updated, 42 pages, 25 PostScript
figures, accepted for publication in Phys. Rev.
Next-to-Leading Order Cross Sections for Tagged Reactions
We extend the phase space slicing method of Giele, Glover and Kosower for
performing next-to-leading order jet cross section calculations in two
important ways: we show how to include fragmentation functions and how to
include massive particles. These extensions allow the application of this
method to not just jet cross sections but also to cross sections in which a
particular final state particle, including a or -meson, is tagged.Comment: 36 pages, Latex Small corrections to text. To appear in Phys. Rev.
Soft Gluon Resummation for Heavy Quark Electroproduction
We present the threshold resummation for the cross section for
electroproduction of heavy quarks. We work to next-to-leading logarithmic
accuracy, and in single-particle inclusive kinematics. We provide
next-to-leading and next-to-next-to-leading order expansions of our resummed
formula, and examine numerically the quality of these finite order
approximations. For the case of charm we study their impact on the structure
function and its differential distribution with respect to the charm
transverse momentum.Comment: 27 pages, 17 figure
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/re-profile existing compounds used in humans to identify those that may induce autophagy in the brain. A key challenge with this approach is to assess if any hits identified can induce neuronal autophagy at concentrations that would be seen in humans taking the drug for its conventional indication. Here we report that felodipine, an L-type calcium channel blocker and anti-hypertensive drug, induces autophagy and clears diverse aggregate-prone, neurodegenerative disease-associated proteins. Felodipine can clear mutant α-synuclein in mouse brains at plasma concentrations similar to those that would be seen in humans taking the drug. This is associated with neuroprotection in mice, suggesting the promise of this compound for use in neurodegeneration
Accretion of Planetary Material onto Host Stars
Accretion of planetary material onto host stars may occur throughout a star's
life. Especially prone to accretion, extrasolar planets in short-period orbits,
while relatively rare, constitute a significant fraction of the known
population, and these planets are subject to dynamical and atmospheric
influences that can drive significant mass loss. Theoretical models frame
expectations regarding the rates and extent of this planetary accretion. For
instance, tidal interactions between planets and stars may drive complete
orbital decay during the main sequence. Many planets that survive their stars'
main sequence lifetime will still be engulfed when the host stars become red
giant stars. There is some observational evidence supporting these predictions,
such as a dearth of close-in planets around fast stellar rotators, which is
consistent with tidal spin-up and planet accretion. There remains no clear
chemical evidence for pollution of the atmospheres of main sequence or red
giant stars by planetary materials, but a wealth of evidence points to active
accretion by white dwarfs. In this article, we review the current understanding
of accretion of planetary material, from the pre- to the post-main sequence and
beyond. The review begins with the astrophysical framework for that process and
then considers accretion during various phases of a host star's life, during
which the details of accretion vary, and the observational evidence for
accretion during these phases.Comment: 18 pages, 5 figures (with some redacted), invited revie
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