754 research outputs found
Amplified spontaneous emission-based technique for simultaneous measurement of temperature and strain by combining active fiber with fiber gratings
This article reports on an optical fiber-based sensing system for carrying out the simultaneous measurement of temperature and strain. The sensor design is based on the combination of active dopedoptical fiber and fiber gratings. Erbium/ytterbium co-doped fiber is used to meet the requirements for both high temperature responsivity and small sensor size to address smart structure applications. The temperature dependence of the amplified spontaneous emission power under different pump wavelengths is used as the basis of the sensor and an optical reference to enhance the measurement resolution is discussed. The feasibility of this technique for simultaneous measurement of temperature and strain is demonstrated
Study of self-alignment of μBGA packages
In this paper, a detailed study of the self-alignment
of BGA packages is presented. Complete self-alignment can be
achieved even for a misalignment of the package of larger than
50% off the test board pad centres. A small residual displacement
of the package from perfect alignment after reflow is observed.
The reason for this displacement is the action of gas flow viscous
drag on the package during reflow. The use of eutectic SnPb solder
paste slightly reduces self-aligning ability, due to the increase in
the solder volume, which reduces the restoring force. Exposure of
the solder paste to a 25 C and 85% RH humidity environment
also has a detrimental effect on the self-alignment of the BGA
package, due to solvent evaporation and moisture absorption in
the paste causing solderability degradation. The self-alignment of
the package is also affected when there is slow spreading of molten
solder on the pad surface. This is attributed to the reduction of
restoring force due to the decrease in effective wetting surface area
of the board pad
Asymmetric Fluid Criticality II: Finite-Size Scaling for Simulations
The vapor-liquid critical behavior of intrinsically asymmetric fluids is
studied in finite systems of linear dimensions, , focusing on periodic
boundary conditions, as appropriate for simulations. The recently propounded
``complete'' thermodynamic scaling theory incorporating pressure
mixing in the scaling fields as well as corrections to scaling
, is extended to finite , initially in a grand
canonical representation. The theory allows for a Yang-Yang anomaly in which,
when , the second temperature derivative,
, of the chemical potential along the phase
boundary, , diverges when T\to\Tc -. The finite-size
behavior of various special {\em critical loci} in the temperature-density or
plane, in particular, the -inflection susceptibility loci and the
-maximal loci -- derived from where -- is carefully elucidated and
shown to be of value in estimating \Tc and \rhoc. Concrete illustrations
are presented for the hard-core square-well fluid and for the restricted
primitive model electrolyte including an estimate of the correlation exponent
that confirms Ising-type character. The treatment is extended to the
canonical representation where further complications appear.Comment: 23 pages in the two-column format (including 13 figures) This is Part
II of the previous paper [arXiv:cond-mat/0212145
Exact trace formulae for a class of one-dimensional ray-splitting systems
Based on quantum graph theory we establish that the ray-splitting trace
formula proposed by Couchman {\it et al.} (Phys. Rev. A {\bf 46}, 6193 (1992))
is exact for a class of one-dimensional ray-splitting systems. Important
applications in combinatorics are suggested.Comment: 14 pages, 3 figure
Interruption of torus doubling bifurcation and genesis of strange nonchaotic attractors in a quasiperiodically forced map : Mechanisms and their characterizations
A simple quasiperiodically forced one-dimensional cubic map is shown to
exhibit very many types of routes to chaos via strange nonchaotic attractors
(SNAs) with reference to a two-parameter space. The routes include
transitions to chaos via SNAs from both one frequency torus and period doubled
torus. In the former case, we identify the fractalization and type I
intermittency routes. In the latter case, we point out that atleast four
distinct routes through which the truncation of torus doubling bifurcation and
the birth of SNAs take place in this model. In particular, the formation of
SNAs through Heagy-Hammel, fractalization and type--III intermittent mechanisms
are described. In addition, it has been found that in this system there are
some regions in the parameter space where a novel dynamics involving a sudden
expansion of the attractor which tames the growth of period-doubling
bifurcation takes place, giving birth to SNA. The SNAs created through
different mechanisms are characterized by the behaviour of the Lyapunov
exponents and their variance, by the estimation of phase sensitivity exponent
as well as through the distribution of finite-time Lyapunov exponents.Comment: 27 pages, RevTeX 4, 16 EPS figures. Phys. Rev. E (2001) to appea
Glial activation involvement in neuronal death by Japanese encephalitis virus infection
Japanese encephalitis is characterized by profound neuronal destruction/dysfunction and concomitant microgliosis/astrogliosis. Although substantial activation of glia is observed in Japanese encephalitis virus (JEV)-induced Japanese encephalitis, the inflammatory responses and consequences of astrocytes and microglial activation after JEV infection are not fully understood. In this study, infection of cultured neurons/glia with JEV caused neuronal death and glial activation, as evidenced by morphological transformation, increased cell proliferation and elevated tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6 and RANTES (regulated upon activation, normal T-cell expressed and secreted) production. Replication-competent JEV caused all glial responses and neurotoxicity. However, replication-incompetent JEV lost these abilities, except for the ability to change microglial morphology. The bystander damage caused by activated glia also contributed to JEV-associated neurotoxicity. Microglia underwent morphological changes, increased cell proliferation and elevated TNF-alpha, IL-1 beta, IL-6 and RANTES expression in response to JEV infection. In contrast, IL-6 and RANTES expression, but no apparent morphological changes, proliferation or TNF-alpha/IL-1 beta expression, was demonstrated in JEV-infected astrocytes. Supernatants of JEV-infected microglia, but not JEV-infected astrocytes, induced glial activation and triggered neuronal death. Antibody neutralization studies revealed that TNF-alpha and IL-1 beta, but not RANTES or IL-6, released by activated microglia appeared to play roles in JEV-associated neurotoxicity. In conclusion, following JEV infection, neuronal death was accompanied by concomitant microgliosis and astrogliosis, and neurotoxic mediators released by JEV-activated microglia, rather than by JEV-activated astrocytes, had the ability to amplify the microglial response and cause neuronal death
Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy
BACKGROUND: Hypertrophic cardiomyopathy (HCM) related myocardial vascular remodelling may lead to the reduction of myocardial blood supply and a subsequent progressive loss of cardiac function. This process has been difficult to observe and thus their connection remains unclear. Here we used non-invasive myocardial blood flow sensitive CMR to show an impairment of resting myocardial perfusion in a mouse model of naturally occurring HCM. METHODS: We used a mouse model (DBA/2 J; D2 mouse strain) that spontaneously carries variants in the two most susceptible HCM genes—Mybpc3 and Myh7 and bears the key features of human HCM. The C57BL/6 J (B6) was used as a reference strain. Mice with either B6 or D2 backgrounds (male: n = 4, female: n = 4) underwent cine-CMR for functional assessment at 9.4 T. Left ventricular (LV) wall thickness was measured in end diastolic phase by cine-CMR. Quantitative myocardial perfusion maps (male: n = 5, female: n = 5 in each group) were acquired from arterial spin labelling (cine ASL-CMR) at rest. Myocardial perfusion values were measured by delineating different regions of interest based on the LV segmentation model in the mid ventricle of the LV myocardium. Directly after the CMR, the mouse hearts were removed for histological assessments to confirm the incidence of myocardial interstitial fibrosis (n = 8 in each group) and small vessel remodelling such as vessel density (n = 6 in each group) and perivascular fibrosis (n = 8 in each group). RESULTS: LV hypertrophy was more pronounced in D2 than in B6 mice (male: D2 LV wall thickness = 1.3 ± 0.1 mm vs B6 LV wall thickness = 1.0 ± 0.0 mm, p < 0.001; female: D2 LV wall thickness = 1.0 ± 0.1 mm vs B6 LV wall thickness = 0.8 ± 0.1 mm, p < 0.01). The resting global myocardial perfusion (myocardial blood flow; MBF) was lower in D2 than in B6 mice (end-diastole: D2 MBF(global) = 7.5 ± 0.6 vs B6 MBF(global) = 9.3 ± 1.6 ml/g/min, p < 0.05; end-systole: D2 MBF(global) = 6.6 ± 0.8 vs B6 MBF(global) = 8.2 ± 2.6 ml/g/min, p < 0.01). This myocardial microvascular dysfunction was observed and associated with a reduction in regional MBF, mainly in the interventricular septal and inferior areas of the myocardium. Immunofluorescence revealed a lower number of vessel densities in D2 than in B6 (D2 capillary = 31.0 ± 3.8% vs B6 capillary = 40.7 ± 4.6%, p < 0.05). Myocardial collagen volume fraction (CVF) was significantly higher in D2 LV versus B6 LV mice (D2 CVF = 3.7 ± 1.4% vs B6 CVF = 1.7 ± 0.7%, p < 0.01). Furthermore, a higher ratio of perivascular fibrosis (PFR) was found in D2 than in B6 mice (D2 PFR = 2.3 ± 1.0%, B6 PFR = 0.8 ± 0.4%, p < 0.01). CONCLUSIONS: Our work describes an imaging marker using cine ASL-CMR with a potential to monitor vascular and myocardial remodelling in HCM
Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain
Background: Klebsiella pneumoniae displaying the hypermucoviscosity (HV) phenotype are considered more virulent than HV-negative strains. Nevertheless, the emergence of tissue-abscesses-associated HV-negative isolates motivated us to re-evaluate the role of HV-phenotype. Results: Instead of genetically manipulating the HV-phenotype of K. pneumoniae, we selected two clinically isolated K1 strains, 1112 (HV-positive) and 1084 (HV-negative), to avoid possible interference from defects in the capsule. These well-encapsulated strains with similar genetic backgrounds were used for comparative analysis of bacterial virulence in a pneumoniae or a liver abscess model generated in either naive or diabetic mice. In the pneumonia model, the HV-positive strain 1112 proliferated to higher loads in the lungs and blood of naive mice, but was less prone to disseminate into the blood of diabetic mice compared to the HV-negative strain 1084. In the liver abscess model, 1084 was as potent as 1112 in inducing liver abscesses in both the naive and diabetic mice. The 1084-infected diabetic mice were more inclined to develop bacteremia and had a higher mortality rate than those infected by 1112. A mini-Tn5 mutant of 1112, isolated due to its loss of HV-phenotype, was avirulent to mice. Conclusion: These results indicate that the HV-phenotype is required for the virulence of the clinically isolated HV-positive strain 1112. The superior ability of the HV-negative stain 1084 over 1112 to cause bacteremia in diabetic mice suggests that factors other than the HV phenotype were required for the systemic dissemination of K. pneumoniae in an immunocompromised setting
Negotiated economic grid brokering for quality of service
We demonstrate a Grid broker's job submission system and its selection process for finding the provider that is most likely to be able to complete work on time and on budget. We compare several traditional site selection mechanisms with an economic and Quality of Service (QoS) oriented approach. We show how a greater profit and QoS can be achieved if jobs are accepted by the most appropriate provider. We particularly focus upon the benefits of a negotiation process for QoS that enables our selection process to occur
- …