Effect of Increasing Military-Related Load Carriage Magnitude on Dynamic Postural Stability in Men and Women

Please download pdf version here

Differential Responses in the Growth Hormone-Insulin-Like Growth Factor-1 Axis Following Simulated Military Operational Stress

Click the PDF icon to download the abstract

Their Day in Court: Assessing Guilty Plea Rates Among Terrorists

Individuals who are charged for traditional crimes are substantially more likely to plead guilty than individuals who are charged under the same statutes but who are officially involved in terrorism (Smith & Damphousse, 1998). Relying on a structural–contextual theory framework, a quantitative analysis not only confirmed that terrorists plead guilty more often than traditional offenders but that the defendant’s age and number of counts in the indictment are important predictors. Directions for future research are suggested.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Simulated Military Operational Stress Negatively Impacts Psychomotor Vigilance and Neurocognitive Biomarkers in Men and Women

Click the PDF icon to download the abstract

Impact of Operational Stress on Motor Evoked Potentials in Military Personnel

Click the PDF icon to download the abstract

Similar Corticospinal Excitability in Military Men and Women During Simulated Operational Stress

Click the PDF icon to download the abstrac

Impact of Aerobic Fitness on Cognitive Performance During Simulated Military Operational Stress

Click the PDF icon to download the abstrac

Phosphofructokinase Relocalizes into Subcellular Compartments with Liquid-like Properties In Vivo.

Although much is known about the biochemical regulation of glycolytic enzymes, less is understood about how they are organized inside cells. We systematically examine the dynamic subcellular localization of glycolytic protein phosphofructokinase-1/PFK-1.1 in Caenorhabditis elegans. We determine that endogenous PFK-1.1 localizes to subcellular compartments in vivo. In neurons, PFK-1.1 forms phase-separated condensates near synapses in response to energy stress from transient hypoxia. Restoring animals to normoxic conditions results in cytosolic dispersion of PFK-1.1. PFK-1.1 condensates exhibit liquid-like properties, including spheroid shapes due to surface tension, fluidity due to deformations, and fast internal molecular rearrangements. Heterologous self-association domain cryptochrome 2 promotes formation of PFK-1.1 condensates and recruitment of aldolase/ALDO-1. PFK-1.1 condensates do not correspond to stress granules and might represent novel metabolic subcompartments. Our studies indicate that glycolytic protein PFK-1.1 can dynamically form condensates in vivo

Shared and Unique Abnormalities in Sleep and Rest- Activity Rhythms in Residential and Outpatient Schizophrenia Spectrum Disorder Patients

Background: Sleep and rest-activity-rhythm (RAR) abnormalities are commonly reported in schizophrenia spectrum disorder (SSD) patients. However, an extensive characterization of RAR alterations in SSD patients relative to healthy control subjects is currently lacking. Furthermore, differences in RAR parameters between residential and outpatient SSD individuals, including their relationships with the SSD clinical symptoms, have not been thoroughly examined. Methods: Two hundred and fifty participants, including one hundred and thirty-seven patients diagnosed with Schizophrenia Spectrum Disorders (SSD, seventy-nine residential patients, and fifty-eight outpatients) and one hundred and thirteen healthy comparison (HC) subjects, were recruited at ten different mental health centers in Northern Italy Ras as part of the DiAPAson project. To monitor habitual sleep-wake patterns, study participants were instructed to wear an ActiGraph GT9X on the nondominant wrist for seven consecutive days. Data from 20 participants were excluded due to having either less than 3 days of actigraphy data or being detected as an outlier. Therefore, 68 residential SSD patients, 54 SSD outpatients, and 108 HC individuals were included in further analyses. RAR parameters, including M10, L5 relative amplitude (RA), intra-daily variability (IV), inter-daily stability (IS), alpha, beta, F-statistic (F-stat), and sleep parameters (i.e., total sleep time [TST], wake after sleep onset [WASO]) were computed for each study participant. Moreover, negative symptoms were assessed in residential and outpatient SSD patients with the Brief Negative Symptom Scale (BNSS). Analysis of covariance (ANCOVA) was performed to identify differences in RAR and sleep parameters between HC, outpatient SSD, and residential SSD groups after controlling for age and sex. Statistical significance was determined by applying Bonferroni's correction for multiple comparisons. For RAR/sleep parameters showing significant ANCOVA differences across the three groups, the Tukey HSD test was used for pairwise comparison, including differences between each SSD population with HC and between the two SSD samples. Finally, correlation analyses between BNSS scores and RAR parameters were performed. Results: Among sleep parameters, TST (F(2, 225) = 79.43, p < 0.001), but not WASO, was different between groups after Bonferroni's correction for multiple comparisons. Furthermore, except RA and F-stat, all RAR parameters, including IV (F(2, 225) = 8.35, p = 0.003), M10 (F(2, 225) = 31.13, p < 0.001), L5 (F(2, 225) = 7.91, p = 0.005), alpha (F(2, 225) = 46.092, p < 0.001), beta (F(2, 225) = 27.68, p < 0.001), and IS (F(2, 225) = 14.33, p < 0.001) were significantly different across the three groups. Specifically, TST was higher in both SSD groups compared to HC (t = 11.18, p < 0.001, t = 9.28, p < 0.001; for residential and outpatients SSD vs HC, respectively). Both SSD groups showed also lower M10 (residential vs control: t = -7.71 and p < 0.001; outpatients vs control: t = -4.2 and p < 0.001) and L5 (residential vs control: t = -3.79 and p < 0.001; outpatients vs control: t = -2.43 and p = 0.048), along with higher alpha (residential vs control: t = 7.43 and p < 0.001; outpatients vs control: t = 8.25 and p < 0.001) compared to HC. Residential SSD patients had higher IV (residential vs control: t = 2.98 and p = 0.010), IS (residential vs control: t = 5.35 and p < 0.001), and beta (residential vs control: t = 7.16 and p < 0.001) relative to HC. In contrast, SSD outpatients showed no differences in any of those three measures compared to HC. We also observed that M10 (t = 2.67, p = 0.024) was higher in SSD outpatients compared to residential patients, whereas IV (t = -3.95, p < 0.001), beta (t = -5.51, p < 0.001), and IS (t = -2.73, p = 0.020) were higher in residential compared to SSD outpatients. Furthermore, residential patients had worse negative symptoms compared to outpatients (t = 2.6299, p = 0.010), and IS correlated with the severity of negative symptoms across all SSD patients (R = 0.248, p = 0.024). Conclusions: In this study, we found that compared to healthy controls, residential and outpatient SSD individuals had both unique (IV, beta, IS) and shared (e.g., TST, M10, L5, alpha) abnormalities in RAR/sleep measures, and IS was associated with the severity of the SSD clinical symptoms

Slow Wave Activity Sleep is Significantly Associated with Decision-Making During Simulated Military Operational Stress

See Attached Abstrac