ADRA1A-Gα_q signalling potentiates adipocyte thermogenesis through CKB and TNAP

Noradrenaline (NA) regulates cold-stimulated adipocyte thermogenesis(1). Aside from cAMP signalling downstream of β-adrenergic receptor activation, how NA promotes thermogenic output is still not fully understood. Here, we show that coordinated α(1)-adrenergic receptor (AR) and β(3)-AR signalling induces the expression of thermogenic genes of the futile creatine cycle(2,3), and that early B cell factors, oestrogen-related receptors and PGC1α are required for this response in vivo. NA triggers physical and functional coupling between the α(1)-AR subtype (ADRA1A) and Gα(q) to promote adipocyte thermogenesis in a manner that is dependent on the effector proteins of the futile creatine cycle, creatine kinase B and tissue-non-specific alkaline phosphatase. Combined Gα(q) and Gα(s) signalling selectively in adipocytes promotes a continual rise in whole-body energy expenditure, and creatine kinase B is required for this effect. Thus, the ADRA1A–Gα(q)–futile creatine cycle axis is a key regulator of facultative and adaptive thermogenesis

Sleep disorders and accidental risk in a large group of regular registered highway drivers.

International audienceDespite convincing evidence regarding the risk of highway accidents due to sleepiness at the wheel, highway drivers still drive while sleepy. Sleep disorders can affect driving skills, but the relative impact of sleep complaints among a large population of highway drivers is still unknown. Out of 37,648 questionnaires completed by frequent highway users (registered in an electronic payment system), we ran our analyses on 35,004 drivers who responded to all items. The questionnaire previously used in a telephone survey included socio-demographics, driving and sleep disorders items (Basic Nordic Sleep Questionnaire) and the Epworth Sleepiness Scale. Of all drivers, 16.9% complained of at least one sleep disorder, 5.2% reported obstructive sleep apnea syndrome, 9.3% insomnia, and 0.1% narcolepsy and hypersomnia; 8.9% of drivers reported experiencing at least once each month an episode of sleepiness at the wheel so severe they had to stop driving. One-third of the drivers (31.1%) reported near-miss accidents (50% being sleep-related), 2520 drivers (7.2%) reported a driving accident in the past year, and 146 (5.8%) of these driving accidents were sleep-related. The highest risk of accidents concerned patients suffering from narcolepsy and hypersomnia (odds ratio 3.16, p<.01) or multiple sleep disorders (odds ratio 1.46, p<.001). Other major risk factors were age [18-30 years (OR 1.42, p<.001)] and being unmarried (OR 1.21-fold, p<.01). In regular highway drivers, sleepiness at the wheel or sleep disorders such as hypersomnia and narcolepsy are responsible for traffic accidents independent of age, sex, marital status or socio-professional categories

ADRA1A-Gα signalling potentiates adipocyte thermogenesis through CKB and TNAP

Noradrenaline (NA) regulates cold-stimulated adipocyte thermogenesis. Aside from cAMP signalling downstream of β-adrenergic receptor activation, how NA promotes thermogenic output is still not fully understood. Here, we show that coordinated α-adrenergic receptor (AR) and β-AR signalling induces the expression of thermogenic genes of the futile creatine cycle, and that early B cell factors, oestrogen-related receptors and PGC1α are required for this response in vivo. NA triggers physical and functional coupling between the α-AR subtype (ADRA1A) and Gα to promote adipocyte thermogenesis in a manner that is dependent on the effector proteins of the futile creatine cycle, creatine kinase B and tissue-non-specific alkaline phosphatase. Combined Gα and Gα signalling selectively in adipocytes promotes a continual rise in whole-body energy expenditure, and creatine kinase B is required for this effect. Thus, the ADRA1A-Gα-futile creatine cycle axis is a key regulator of facultative and adaptive thermogenesis

Upgrading the high contrast imaging facility SPHERE: science drivers and instrument choices

International audienceSPHERE+ is a proposed upgrade of the SPHERE instrument at the VLT, which is intended to boost the current performances of detection and characterization for exoplanets and disks. SPHERE+ will also serve as a demonstrator for the future planet finder (PCS) of the European ELT. The main science drivers for SPHERE+ are 1/ to access the bulk of the young giant planet population down to the snow line (3 − 10 au), to bridge the gap with complementary techniques (radial

Encyclopédie des historiographies : Afriques, Amériques, Asies

Quels rapports les sociétés humaines entretiennent-elles avec leur passé et quels récits font-elles du temps révolu ? Pour ce premier volume de l’Encyclopédie des historiographies. Afriques, Amériques, Asies, 157 spécialistes représentant 88 institutions académiques en France et dans le monde explorent l’univers des productions humaines qui constituent des sources pour l’historien et déchiffrent les nombreuses modalités (« scientifiques », littéraires, artistiques, monumentales…) de l’écriture du passé. Évoquant tour à tour l’Afrique, l’Amérique latine, l’Asie, l’Océanie, les 216 notices de l’ouvrage présentent des matériaux historiques de toute nature, issus de toutes les époques, souvent méconnus, ainsi que l’histoire de leurs usages. L’entreprise collective qu’est l’Encyclopédie se veut novatrice : il s’agit de susciter une réflexion historiographique résolument non-occidentalo-centrée qui complète utilement les démarches épistémologiques traditionnelles. Nouvel outil de connaissance historique forgé à l’heure de la mondialisation, l’Encyclopédie des historiographies est aussi une véritable invitation au voyage.What are the different types of relations that non-Western societies upkeep with their past and how are narratives about the past produced by them? In this first volume of the Encyclopaedia of Historiography: Africa, America, Asia, 157 specialists from 88 international academic institutions explore the wealth of evidence that constitutes source material for historians. They also examine the immensely diverse modes or genres of narrated history: “scientific”, literary, artistic, architectural, etc. 216 entries dealing with Africa, Latin America, Oceania, and Asia, cover a large variety of sources, including many which are unfamiliar to the Western or non-Western reader, along with the history of how they have been exploited. By bringing together for the first time such an abundance of material the reader is offered the possibility of exploring continents and building meaningful connections across space and time. In addition to being a new tool for historical enquiry in an era of globalization, this encyclopaedia is also an invitation to travel the world