Development of wearable, screen-printable conductive polymer biosensors on flexible and textile substrates

Wearable biosensors have great potential for real-time diagnostics, but have been encumbered by costly fabrication processes, rigid materials, and inadequate sensitivity for physiological ranges. Sweat has hitherto been an understudied sample for measurement of components like pH and lactate, which can provide meaningful guidance for wound healing, eczema, and sports medicine applications. This thesis presents the development of a flexible, textile-based, screen-printed electrode system for biosensing applications. Furthermore, a flexible, pH-sensitive composite for textile substrates is developed by mixing polyaniline with dodecylbenzene sulfonic acid and textile screen-printing ink. The optimized composite’s pH response is compared to electropolymerized and drop-cast polyaniline sensors via open circuit potential measurements. A linear response is observed for all sensors between pH 3-10, with the composite demonstrating sufficient response time and a sensitivity better than -20 mV/pH, exceeding existing flexible screen-printed pH sensors. Investigations into a potentiometric, non-enzymatic lactate sensor using polyaminophenylboronic acid are also discussed

A comparison of Pull-Out and Co-Teaching models on the reading performance of third through fifth grade elementary students with a diagnosed specific learning disability in reading

The purpose of this mixed methods study was to investigate the design and implementation of the Pull-Out and the Co-Teaching special education resource models at 2 elementary schools in the Golden Cactus Elementary School District and to compare the student reading performance of 56 3rd through 5th grade students, by grade level, who participated in one of the two models at the selected schools during the 2010-2011 school year, to determine which model was associated with higher levels of student success and under what circumstances. The following two research questions guided this study: 1. How does the 2010-2011 reading performance of 3rd through 5th grade elementary students with a diagnosed specific learning disability in reading, as measured by the Galileo criterion-referenced assessment, compare by Program service models at 2 selected elementary schools in the Golden Cactus Elementary School District? 2. What type of professional development, resources, and support, if any, do the Golden Cactus Elementary School District elementary school principals, resource teachers and co-teaching general education teachers at two selected elementary school sites believe are needed to best implement the Pull-Out and Co-Teaching special education Resource Model delivery options at their sites? Overall, the study revealed no significance between the Co-Teaching and Pull-Out instructional models on the student reading achievement of 3rd, 4th and 5th grade students identified with a specific learning disability in reading. Because the findings revealed little difference overall in compared performance, and because these findings are counter to literature findings, further research will need to be conducted in order to truly make conclusions about the effectiveness of the 2 programs. The results of this study suggest that proper training was needed to create a foundation for expected instruction. It also suggests that there was a range of understanding which impacts student achievement. This study was the first step in examining the impact of both Pull-Out and Co-Teaching instructional practices on students identified with a specific learning disability. It is important that instructors be assisted with the specific skills needed to implement the instructional delivery models critical for higher levels of studen

Papel del inmunoproteosoma en enfermedades neurodegenerativas y cáncer

Los avances científicos y la constante evolución de los métodos de experimentación han permitido conocer la gran importancia que tiene el proteosoma en nuestro organismo. Este complejo intracelular, capaz de degradar proteínas una vez señalizadas, ha demostrado ser un importante actor en diferentes enfermedades, debido a que su mal funcionamiento puede acarrear desequilibrios proteicos, con diferentes e importantes consecuencias. Así, se ha probado que una sobreexpresión del mismo, conduce a una degradación excesiva de ciertas proteínas, sobre todo aquellas de tiempo de vida corto, modificando así el curso normal del ciclo celular. Esto tendría como consecuencias una proliferación descontrolada de células, o una inhibición de la muerte celular. Todas estas modificaciones en las concentraciones plasmáticas de determinadas proteínas, pueden desembocar finalmente en un proceso oncológico. Es así como ha surgido una nueva familia de fármacos anticancerosos, los inhibidores del proteosoma, capaces de frenar dicho proceso patológico. También se sospecha, que la baja actividad del mismo puede disminuir la degradación de proteínas, y provocar un aumento de concentración de estas, tanto en el interior como en el exterior celular. En ocasiones, estas proteínas estarán mal plegadas o defectuosas, y se formarán agregados proteicos, que puede provocar un mal funcionamiento celular. Este sería el caso de las enfermedades neurodegenerativas. Muchas de estas patologías se caracterizan por la presencia de conjugados proteicos, como los ovillos neurofibrilares en Alzheimer, los cuerpos de Lewys en el tronco cerebral en pacientes con Parkinson, agregados de huntingtina en la enfermedad de Huntington, o cuerpos de bunina en la Esclerosis Lateral Amiotrófica. Por otro lado, tanto el cáncer como las enfermedades neurodegenerativas se acompañan de procesos inflamatorios, que pueden afectar a la homeostasis proteica, alterando el tipo y la cantidad de proteosomasUniversidad de Sevilla. Grado en Farmaci

The Perceptions of the Effectiveness of the Phoenix Alternative Program

Many school districts throughout the United States utilize alternative schools for students who have not been successful in a traditional school setting. The Phoenix Program is a second chance alternative school in Mobile, Alabama that provides educational opportunities to students who are at risk of dropping out or school or under a long-term suspension from a regular school program. This study was conducted to determine the perceptions of the effectiveness of the Phoenix Program on students who have been suspended from their assigned school for a long term. Participants in this study included 36 principals and assistant principals, 30 students, 18 parents, and 17 staff members. The participants indicated their perceptions of the effectiveness of the Phoenix Program by responding to questions on a survey which utilized a Likert Scale. Statistical data was also collected on students who attended the Phoenix Program during the years 2005-2006 and 2006-2007. Using data obtained from the Assistant Superintendent for Student Services of the Mobile County Public School System, an analysis was conducted to determine the number of students who showed a decrease in discipline referrals, avoided further suspensions, and graduated from high school with a diploma. A one-way ANOVA was also conducted to determine if there was a significant difference among students\u27 who attended the Phoenix Program, the parents of students who attended the Phoenix Program, Phoenix Program staff members\u27, and principals\u27 and assistant principals\u27 perceptions of the effectiveness of the Phoenix Program. This study indicated that the majority of the students who attended the Phoenix Program graduated from high school with a diploma. The study also indicated that most students showed a decrease in discipline referrals but more than half of the students were suspended from school again. After conducting the one-way ANOVA it was concluded that there was a significant difference among current students, the parents of current students, staff members, and principals and assistant principals

Rapport sur les réseaux grands débits et l\u27entrée dans la société de l\u27information

Rapport de l\u27 Office parlementaire d\u27évaluation des choix scientifiques et technologiques sur la situation des nouvelles technologies de l\u27information et de la communication en France et sur les stratégies politiques à développer pour l\u27entrée dans la société de l\u27information

Interview with Carolyn Montague Laffitte and Callie O. H. Wienges

https://digitalcommons.winthrop.edu/scmotheroftheyear/1004/thumbnail.jp

Profit Shifting Frictions and the Geography of Multinational Activity

We develop a quantitative general equilibrium model of multinational activity embedding corporate taxation and profit shifting. In addition to trade and investment frictions, our model shows that profit-shifting frictions shape the geography of multinational production. Key to our model is the distinction between the corporate tax elasticity of real activity and profit shifting. The quantification of our model requires estimates of shifted profits flows. We provide a new, model-consistent methodology to calibrate bilateral profit-shifting frictions based on accounting identities. We simulate various tax reforms aimed at curbing tax-dodging practices of multinationals and their impact on a range of outcomes, including tax revenues and production. Our results show that the effects of the international relocation of firms across countries are of comparable magnitude as the direct gains in taxable income