Fierce lions, angry mice and fat-tailed sheep: Animal encounters in the ancient Near East

Animals have always been an integral part of human existence. In the ancient Near East, this is evident in the record of excavated assemblages of faunal remains, iconography and – for the later historical periods – texts. Animals have predominantly been examined as part of consumption and economy, and while these are important aspects of society in the ancient Near East, the relationships between humans and animals were extremely varied and complex. Domesticated animals had great impact on social, political and economic structures – for example cattle in agriculture and diet, or donkeys and horses in transport, trade and war. Fantastic mythological beasts such as lion-headed eagles or Anzu-birds in Mesopotamia or Egyptian deities such as the falcon-headed god Horus were part of religious beliefs and myths, while exotic creatures such as lions were part of elite symbolling from the fourth millennium bc onward. In some cases, animals also intruded on human lives in unwanted ways by scavenging or entering the household; this especially applies to small or wild animals. But animals were also attributed agency with the ability to solve problems; the distinction between humans and other animals often blurs in ritual, personal and place names, fables and royal ideology. They were helpers, pets and companions in life and death, peace and war. An association with cult and mortuary practices involves sacrifice and feasting, while some animals held special symbolic significance. This volume is a tribute to the animals of the ancient Near East (including Mesopotamia, Anatolia, the Levant and Egypt), from the fourth through first millennia bc, and their complex relationship with the environment and other human and nonhuman animals. Offering faunal, textual and iconographic studies, the contributions present a fascinating array of the many ways in which animals influence human life and death, and explore new perspectives in the exciting field of human-animal studies as applied to this part of the world

Relating the impacts of regenerative farming practices to soil health and carbon sequestration on Gotland, Sweden

Land degradation, greenhouse gas emissions and biodiversity loss through agriculture are some of the greatest challenges we are facing today. Fertile and productive soils are the basis of life on this planet and need to be protected and restored to support a growing population and lower negative impacts of climate change. Regenerative agriculture (RA) claims to improve environmental, social, and economic facets of food production. Its emphasis lies on carbon sequestration for climate change mitigation, biodiversity, and food security through the regeneration of degraded land. The concept of regenerative agriculture has gained attention both in mainstream media and in academic literature in recent years. However, there is no uniform definition of the term so far, and further there is a lack of comprehensive scientific studies on “real-life” farms that are changing their management from conventional to regenerative practices. This thesis investigates the contemporary and historical context of the emerging term regenerative agriculture and identifies the main themes, movements, and debates associated with it by a broad literature research. Further, we compare regenerative farms with conventional farms on Gotland, Sweden in order to draw first conclusions about the impact of certain farming practices on soil physical, chemical, and biological parameters. The soil health on 24 different plots is assessed by a variety of indicators, i.a. total, organic, active, and microbial biomass carbon, C:N ratio, wet aggregate stability, root depth and abundance, earthworm number, nutrient leaching, and soil texture. These parameters are related to four main management practices: application of organic matter, soil disturbance through tillage, crop diversity, and share of legumes through a principal component analysis and multiple linear regressions. We found that the amount of carbon added to the soil had a significant impact on several soil health indicators, mainly organic and active carbon, bulk density, number of earthworms, root abundance, water infiltration, and vegetation density. Reduced tillage was connected to higher wet aggregate stability, and vegetation density. These findings need to be confirmed in the coming years; however, they show that higher organic inputs and less soil disturbance generally had a positive impact on soil health on the investigated farms. Soil sampling will be continued on the same plots in the future to thoroughly investigate the impacts over a longer time period, as the thesis is part of the project Time Zero! Land surveys during farm conversion from abandoned land to regenerative agriculture performed at the Department of Soil and Environment at the Swedish University of Agriculture, Uppsala

The Use and Safety of TNF Inhibitors during Pregnancy in Women with Psoriasis:A Review

Psoriasis is a chronic immune-mediated inflammatory disease affecting women of childbearing potential. Biologic agents, notably Tumor Necrosis Factor inhibitors (TNFi), are the only current non-contraindicated systemic treatment option during pregnancy. TNFi comprised of complete immunoglobulin G (IgG) antibodies antibodies (adalimumab, golimumab, and infliximab) actively cross the placenta from the second trimester and are detectable in the child up to one year postpartum. Data on safety of TNFi are conflicting; however a trend towards drug-specific harm has been reported, with increased risk of congenital malformations and preterm birth. TNFi exposure may alter the immune system of the infant towards hypersensitivity and reduced response to intracellular infections. Confounding by indication should be considered, as chronic inflammatory disease itself may pose a risk of adverse pregnancy outcomes. The quality of the current evidence is very low and no studies specifically address TNFi safety in women with psoriasis. Nonetheless, risks associated with TNFi treatment must be balanced against the as-yet uncertain risk of adverse outcomes in infants born to women with severe psoriasis. We searched PubMed using Medical Subject Headings (MeSH) terms and identified relevant studies and guidelines. Herein, we present the current knowledge of the use and safety of TNFi during pregnancy in women with psoriasis

Return to work and risk of subsequent detachment from employment after myocardial infarction:Insights from Danish nationwide registries

Background Limited data are available on return to work and subsequent detachment from employment after admission for myocardial infarction ( MI ). Methods and Results Using individual‐level linkage of data from nationwide registries, we identified patients of working age (30–65 years) discharged after first‐time MI in the period 1997 to 2012, who were employed before admission. To assess the cumulative incidence of return to work and detachment from employment, the Aalen Johansen estimator was used. Incidences were compared with population controls matched on age and sex. Logistic regression was applied to estimate odds ratios for associations between detachment from employment and age, sex, comorbidities, income, and education level. Of 39 296 patients of working age discharged after first‐time MI , 22 394 (56.9%) were employed before admission. Within 1 year 91.1% (95% confidence interval [ CI ], 90.7%–91.5%) of subjects had returned to work, but 1 year after their return 24.2% (95% CI , 23.6%–24.8%) were detached from employment and received social benefits. Detachment rates were highest in patients aged 60 to 65 and 30 to 39 years, and significantly higher in patients with MI compared with population controls. Predictors of detachment were heart failure (odds ratio 1.20 [95% CI , 1.08–1.34]), diabetes mellitus (odds ratio 1.13 [95% CI , 1.01–1.25]), and depression (odds ratio 1.77 [95% CI , 1.55–2.01]). High education level and high income favored continued employment. Conclusions Despite that most patients returned to work after first‐time MI , about 1 in 4 was detached from employment after 1 year. Several factors including age and lower socioeconomic status were associated with risk of detachment from employment. </jats:sec

Multi-Decadal Decline of Mercury in the North Atlantic Atmosphere Explained by Changing Subsurface Seawater Concentrations

[1] We analyze 1977–2010 trends in atmospheric mercury (Hg) from 21 ship cruises over the North Atlantic (NA) and 15 over the South Atlantic (SA). We find a steep 1990–2009 decline of −0.046 ± 0.010 ng m−3 a−1 (−2.5% a−1) over the NA (steeper than at Northern Hemispheric land sites) but no significant decline over the SA. Surface water Hg0 measurements in the NA show a decline of −5.7% a−1since 1999, and limited subsurface ocean data show an ∼80% decline from 1980 to present. We use a coupled global atmosphere-ocean model to show that the decline in NA atmospheric concentrations can be explained by decreasing oceanic evasion from the NA driven by declining subsurface water Hg concentrations. We speculate that this large historical decline of Hg in the NA Ocean could have been caused by decreasing Hg inputs from rivers and wastewater and by changes in the oxidant chemistry of the atmospheric marine boundary layer.Engineering and Applied Science

An Improved Global Model for Air-Sea Exchange of Mercury: High Concentrations over the North Atlantic

We develop an improved treatment of the surface ocean in the GEOS-Chem global 3-D biogeochemical model for mercury (Hg). We replace the globally uniform subsurface ocean Hg concentrations used in the original model with basin-specific values based on measurements. Updated chemical mechanisms for Hg0/HgII redox reactions in the surface ocean include both photochemical and biological processes, and we improved the parametrization of particle-associated Hg scavenging. Modeled aqueous Hg concentrations are consistent with limited surface water observations. Results more accurately reproduce high-observed MBL concentrations over the North Atlantic (NA) and the associated seasonal trends. High seasonal evasion in the NA is driven by inputs from Hg enriched subsurface waters through entrainment and Ekman pumping. Globally, subsurface waters account for 40% of Hg inputs to the ocean mixed layer, and 60% is from atmospheric deposition. Although globally the ocean is a net sink for 3.8 Mmol Hg y−1, the NA is a net source to the atmosphere, potentially due to enrichment of subsurface waters with legacy Hg from historical anthropogenic sources.Engineering and Applied Science

Puberty disorders among ART-conceived singletons : a Nordic register study from the CoNARTaS group

STUDY QUESTION Do ART-conceived children have an increased risk for puberty disorders? SUMMARY ANSWER Both ART-conceived boys and girls had a higher risk of puberty disorders; early puberty was more common among girls and late puberty among boys. WHAT IS KNOWN ALREADY Some physiological differences in growth and metabolism have been reported for ART-conceived children compared to non-ART-conceived children. Knowledge on pubertal development and disorders in ART-conceived children is limited. STUDY DESIGN, SIZE, DURATION A register-based cohort study was carried out including data from 1985 to 2015. The Committee of Nordic Assisted Reproductive Technology and Safety (CoNARTaS) study population consists of all live and stillborn children, as well as their mothers, registered in the Medical Birth Registers during the study period in Denmark, Sweden, Finland and Norway. PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 122 321 ART-conceived singletons and 6 576 410 non-ART singletons born in Denmark (1994-2014), Finland (1990-2014), Norway (2002-2015) and Sweden (1985-2015) were included. Puberty disorders were defined using International Classification of Diseases and Related Health Problems (ICD)-9/ICD-10 codes and classified in the following groups: late puberty (6268/E30.0), early puberty (2591 and 2958/E30.1 and E30.8) and unspecified disorders (V212 and V579/E30.9 and Z00.3 as well as Z51.80 for Finland). The results in Cox regression were adjusted for maternal age, parity, smoking, gestational diabetes, chronic hypertension, hypertensive disorders during pregnancy and country, and further for either gestational age, birthweight, small for gestational age or large for gestational age. MAIN RESULTS AND THE ROLE OF CHANCE There were 37 869 children with diagnoses related to puberty disorders, and 603 of them were born after ART. ART-conceived children had higher risks for early (adjusted hazard ratio (aHR) 1.45, 95% CI: 1.29-1.64) and late puberty (aHR 1.47, 95% CI: 1.21-1.77). Girls had more diagnoses related to early puberty (aHR 1.46, 95% CI: 1.29-1.66) and boys with late puberty (aHR 1.55, 95% CI: 1.24-1.95). LIMITATIONS, REASONS FOR CAUTION Using reported puberty disorders with ICD codes in health care registers might vary, which may affect the numbers of cases found in the registers. Register data may give an underestimation both among ART and non-ART-conceived children, especially among non-ART children, who may not be as carefully followed as ART-conceived children. Adjustment for causes and duration of infertility, mothers' own puberty characteristics and BMI, as well as children's BMI, was not possible because data were not available or data were missing for the early years. It was also not possible to compare ART to non-ART siblings or to study the pubertal disorders by cause of subfertility owing to a small number of discordant sibling pairs and a large proportion of missing data on cause of subfertility. WIDER IMPLICATIONS OF THE FINDINGS This large, register-based study suggests that ART-conceived children have a higher risk for puberty disorders. However, the mechanisms of infertility and pubertal onset are complex, and ART is a rapidly advancing field with various treatment options. Studying the pubertal disorders of ART-conceived offspring is a continuing challenge. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by the Nordic Trial Alliance: a pilot project jointly funded by the Nordic Council of Ministers and NordForsk (71450), the Central Norway Regional Health Authorities (46045000), the Nordic Federation of Obstetrics and Gynaecology (NF13041, NF15058, NF16026 and NF17043), the Interreg oresund-Kattegat-Skagerrak European Regional Development Fund (ReproUnion project), the Research Council of Norway's Centre of Excellence funding scheme (262700), the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (ALFGBG-70940) and FLUX Consortium 'Family Formation in Flux-Causes, Consequences and Possible Futures', funded by the Strategic Research Council, Academy of Finland (DEMOGRAPHY 345130). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors have no conflicts of interest to disclose.Peer reviewe