Colegio de Educadores de Párvulos de Chile AG

This paper describes the Colegio de Educadores de Párvulos de Chile AG, its organization, operation and activities concerning professional practice and nation wide’s Early Childhood Educational Development. It also presents some collegiate approaches referred to Chilean Educational Reform, at this level.Este artículo intenta describir al Colegio de Educadores de Párvulos de Chile AG, su organización, funcionamiento y actividades realizadas en cuanto al ejercicio profesional y al desarrollo de la Educación Parvularia del país. Presenta también planteamientos de algunas colegiadas referidos al deber ser de la Reforma Educacional chilena en este nivel

The evolution of the CIO profile: Evidence in Chile

The great and dynamic possibilities offered by the information technologies (IT) impose new challenges to the organizations. The new capabilities of IT demand that the skills and abilities of the people in charge of the technological management evolve accordingly. In this context we are intrigued by what is the evolution of the Chief Information Officer (CIO) that endows him/her with the capacity to face such challenges? Are there patterns in the evolution of the CIO profile? To answer these questions we integrated the definitions in the literature for the ideal CIO profile with the academic programs of prestigious universities in a conceptual map. Then we interviewed 26 CIOs working in Chile to contrast their profiles with the conceptual map. From the literature review we found several prescriptive features regarding the profile and role of the CIO in modern organizations. Differences were found between the ideal role and the evolutionary status of Chilean CIOs. In spite of the differences, we found patterns for the evolution of the profile that allowed us to propose hypotheses and recommendations for the evolution of Chilean CIOs. Finally, we believe that this paper offers a powerful diagnose of the CIO profile to be used by organizations, IT professionals and universities to set professional and academic paths for success in the IT leading position

Success Central: Implementing a Program to Meet the Needs of Diverse Learners in a Catholic High School

Catholic high schools are among the most effective educational environments in the United States. Often celebrated as comprehensive and college preparatory, the typical Catholic high school boasts of its graduation rate, percentage of college-bound seniors, National Merit finalists, athletic prowess, and scholarship awards. This article pursues a relatively new theme for most Catholic high schools: creating an environment responsive to the needs of diverse learners. Following a school-within-a-school model, one Catholic high school in the Midwest designed and implemented a program to serve students with special needs. Their insights, struggles, and vision form the basis of this article which chronicles a success story worthy of replication

Thick points study of log-correlated fields

Los campos log-correlacionados son campos aleatorios cuyas correlaciones dependen logarítmicamente de la distancia entre los puntos. Se cree ampliamente que, bajo condiciones suaves, los valores extremos de cualquier campo log-correlacionado caen dentro de la misma clase de universalidad. En otras palabras, su comportamiento será similar al de un ejemplo representativo de esta clase. El campo log-correlacionado más estudiado es el Gaussian Free Field (GFF) en dos dimensiones, un campo Gaussiano centrado cuya función de correlación es la función de Green del Laplaciano. Aunque el GFF en sí mismo no es una función en el sentido tradicional, sus valores extremos pueden estudiarse de manera significativa regularizando el campo. Específicamente, el punto \g-alto del campo se puede definir como \begin{equation*} T(\g)\doteq \left\{x\in D: \limsup_{\e\to0} \frac{\Phi_\e(x)}{\log(1/\e)} = \g \right\}, \end{equation*} donde \Phi_\e denota la aproximación de circle-average del campo. Con el objetivo de explorar las propiedades de universalidad de los thick points en los campos log-correlacionados, presentamos un nuevo objeto que captura la esencia de todas las posibles variantes de estos campos: el pseudo Gaussian Free Field (pGFF). Este es un campo cuyas correlaciones están regidas por la función de Green. En la primera parte de esta tesis, describimos las características fundamentales que hacen del pGFF un objeto adecuado para abordar nuestro estudio. Posteriormente, analizamos los valores extremos del pGFF en el caso unidimensional. En la parte final de esta tesis, estudiamos el comportamiento de los thick points para una clase específica de pGFF. Para esta clase restringida, demostramos que la dimensión de los thick points exhibe un comportamiento universal, coincidiendo con el del GFF. La idea central es utilizar la convergencia mod-Gaussiana para mostrar que las probabilidades de cola de ciertas variables aleatorias se comportan de manera similar a las de las variables Gaussianas.Log-correlated fields are random fields whose correlations depend logarithmically on the distance between points. It is widely believed that, under mild conditions, the extreme values of any log-correlated field fall within the same universality class. In other words, their behavior will resemble that of a representative example from this class. The best-understood log-correlated field is the Gaussian Free Field (GFF) in two dimensions, a centered Gaussian field whose correlation function is the Green’s function of the Laplacian. Although the GFF itself is not a function in the traditional sense, its extreme values can be meaningfully studied by regularizing the field. Specifically, the γ-thick point of the field can be defined as T(a) .= x ∈ D : lim sup ε→0 Φϵ(x) log(1/ε) = γ , where Φϵ denotes the circle-average approximation of the field. With the aim of exploring the universality properties of thick points in log-correlated fields, we introduce a new object that captures the essence of all possible variants of these fields: the pseudo Gaussian Free Field (pGFF). This is a field whose correlations are governed by the Green’s function. In the first part of this thesis, we describe the fundamental characteristics that make the pGFF a suitable object for our study. Subsequently, we analyze the extreme values of the pGFF in the one-dimensional case. In the final part of this thesis, we study the behavior of thick points for a specific class of pGFF. For this restricted class, we demonstrate that the dimension of thick points exhibits universal behavior, matching that of the GFF. The core idea is to use mod-Gaussian convergence to show that the tail probabilities of certain random variables behave similarly to those of Gaussian variables.Este trabajo ha sido parcialmente financiado por: CMM ANID BASAL FB210005Versión original del auto

Articulating bargaining theories: movement, chance, and necessity as descriptive principles

The Nash Demand Game (NDG) has been one of the first models (Nash in Econometrica 21(1):128-140, 1953. ) that has tried to describe the process of negotiation, competition, and cooperation. This model has had enormous repercussions and has leveraged basic and applied research on bargaining processes. Therefore, we wonder whether it is possible to articulate extensive and multiple developments into a single unifying framework. The Viability Theory has this inclusive approach. Thus, we investigate the NDG under this point of view, and, carrying out this work, we find that the answer is not only affirmative but that we also advance in characterising viable NDGs. In particular, we found foundations describe the distributive Bargaining Theory: the principle of movement and the principle of chance and necessity. Finally, this initial work has many interesting perspectives. The probably most important idea is to integrate developments of the Bargaining Theory and thus capture the complexity of the real world in an articulated way

A bibliometric analysis of the first twenty years of soft computing

© 2018, Springer International Publishing AG. Soft Computing was launched in 1997. Today, the journal is becoming twenty years old. Motivated by this anniversary, this article develops a bibliometric analysis of the journal in order to identify the leading trends of the journal in terms of publications and citations. The work considers several issues including the leading authors, institutions and countries. The study also uses a software to develop a graphical analysis. The results show a significant increase of the journal during the last years that has consolidated the journal as a leading one in the field

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications.

Methylation of cytosine deoxynucleotides generates 5-methylcytosine (m(5)dC), a well-established epigenetic mark. However, in higher eukaryotes much less is known about modifications affecting other deoxynucleotides. Here, we report the detection of N(6)-methyldeoxyadenosine (m(6)dA) in vertebrate DNA, specifically in Xenopus laevis but also in other species including mouse and human. Our methylome analysis reveals that m(6)dA is widely distributed across the eukaryotic genome and is present in different cell types but is commonly depleted from gene exons. Thus, direct DNA modifications might be more widespread than previously thought.M.J.K. was supported by the Long-Term Human Frontiers Fellowship (LT000149/2010-L), the Medical Research Council grant (G1001690), and by the Isaac Newton Trust Fellowship (R G76588). The work was sponsored by the Biotechnology and Biological Sciences Research Council grant BB/M022994/1 (J.B.G. and M.J.K.). The Gurdon laboratory is funded by the grant 101050/Z/13/Z (J.B.G.) from the Wellcome Trust, and is supported by the Gurdon Institute core grants, namely by the Wellcome Trust Core Grant (092096/Z/10/Z) and by the Cancer Research UK Grant (C6946/A14492). C.R.B. and G.E.A. are funded by the Wellcome Trust Core Grant. We are grateful to D. Simpson and R. Jones-Green for preparing X. laevis eggs and oocytes, F. Miller for providing us with M. musculus tissue, T. Dyl for X. laevis eggs and D. rerio samples, and to Gurdon laboratory members for their critical comments. We thank U. Ruether for providing us with M. musculus kidney DNA (Entwicklungs- und Molekularbiologie der Tiere, Heinrich Heine Universitaet Duesseldorf, Germany). We also thank J. Ahringer, S. Jackson, A. Bannister and T. Kouzarides for critical input and advice, M. Sciacovelli and E. Gaude for suggestions.This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/nsmb.314

Neoadjuvant immunotherapy in gastrointestinal cancers - The new standard of care?

The development of immune checkpoint inhibitors (ICI) offers novel treatment possibilities for solid cancers, with the crucial benefit of providing higher cure rates. These agents have become part of standard treatments in the metastatic and adjuvant setting for select cancers, such as melanoma, non-small cell lung cancer (NSCLC) or urological malignancies. Currently, there is ample clinical interest in employing ICI in a neoadjuvant setting with a curative intent. This approach is especially supported by the scientific rationale that ICI primarily stimulate the host immune system to eradicate tumor cells, rather than being inherently cytotoxic. Aside from tumor downstaging, neoadjuvant immunotherapy offers the potential of an in situ cancer vaccination, leading to a systemic adjuvant immunological effect after tumor resection. Moreover, preclinical data clearly demonstrate a synergistic effect of ICI with radiotherapy (RT), chemoradiotherapy (CRT) or chemotherapy (ChT). This review harmonizes preclinical concepts with real world data (RWD) in the field of neoadjuvant ICI in gastrointestinal (GI) cancers and discusses their limitations. We believe this is a crucial approach, since up to now, neoadjuvant strategies have been primarily developed by clinicians, whereas the advances in immunotherapy primarily originate from preclinical research. Currently there is limited published data on neoadjuvant ICI in GI cancers, even though neoadjuvant treatments including RT, CRT or ChT are frequently employed in locally advanced/oligometastatic GI cancers (i.e. rectal, pancreatic, esophagus, stomach, etc.). Utilizing established therapies in combination with ICI provides an abundance of opportunities for innovative treatment regimens to further improve survival rates

Bargaining and negative externalities

Artículo de publicación ISITwo important issues in distributive bargaining theory are, first, the conditions under which a negotiation breakdown occurs, and second, what and how source of parties’ bargaining powers influences the properties of a possible agreement. Research based on classicNash’s demand game has explored both questions by sophisticating the original game a lot. As an attempt to deal with both issues under a simpler framework, we propose a modification of the Nash demand game in which bargainers suffer negative externalities proportional to the share of the surplus captured by their rival. It is shown that the negotiator experiencing a relatively high externality level has greater bargaining power and thus, appropriates a larger proportion of the surplus at stake. However, if externality levels are sufficiently high, bargaining powers become incompatible and a negotiation breakdown emerges from the bargaining process. We compare our results with the previous literature, and argue that they can be especially relevant in negotiations held under highly polarized environments