6,263 research outputs found

    Bimodal AGNs in Bimodal Galaxies

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    By their star content, the galaxies split out into a red and a blue population; their color index peaked around u-r=2.5 or u-r=1, respectively, quantifies the ratio of the blue stars newly formed from cold galactic gas, to the redder ones left over by past generations. On the other hand, upon accreting substantial gas amounts the central massive black holes energize active galactic nuclei (AGNs); here we investigate whether these show a similar, and possibly related, bimodal partition as for current accretion activity relative to the past. To this aim we use an updated semianalytic model; based on Monte Carlo simulations, this follows with a large statistics the galaxy assemblage, the star generations and the black hole accretions in the cosmological framework over the redshift span from z=10 to z=0. We test our simulations for yielding in close detail the observed split of galaxies into a red, early and a blue, late population. We find that the black hole accretion activities likewise give rise to two source populations: early, bright quasars and later, dimmer AGNs. We predict for their Eddington parameter λE\lambda_E -- the ratio of the current to the past black hole accretions -- a bimodal distribution; the two branches sit now under λE0.01\lambda_E \approx 0.01 (mainly contributed by low-luminosity AGNs) and around λE0.31\lambda_E \approx 0.3-1. These not only mark out the two populations of AGNs, but also will turn out to correlate strongly with the red or blue color of their host galaxies.Comment: 7 pages, accepted for publication in the Astrophysical Journa

    PMH30 ECONOMIC EVALUATION OF AGOMELATINE IN MAJOR DEPRESSIVE DISORDERS IN IRELAND

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    Conceptual design study of a Harrier V/STOL research aircraft

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    MCAIR recently completed a conceptual design study to define modification approaches to, and derive planning prices for the conversion of a two place Harrier to a V/STOL control, display and guidance research aircraft. Control concepts such as rate damping, attitude stabilization, velocity command, and cockpit controllers are to be demonstrated. Display formats will also be investigated, and landing, navigation and guidance systems flight tested. The rear cockpit is modified such that it can be quickly adapted to faithfully simulate the controls, displays and handling qualities of a Type A or Type B V/STOL. The safety pilot always has take command capability. The modifications studied fall into two categories: basic modifications and optional modifications. Technical descriptions of the basic modifications and of the optional modifications are presented. The modification plan and schedule as well as the test plan and schedule are presented. The failure mode and effects analysis, aircraft performance, aircraft weight, and aircraft support are discussed

    Effect of Level of Farm Mechanization Early in Life on Bone Later in Life

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    OBJECTIVE: To determine whether an active rural lifestyle during childhood and adolescence, defined as low farm mechanization, was associated with bone measures later in life.METHODS: DXA bone data from total body, hip and spine, and pQCT data from 4% and 20% distal radius were obtained on 330 individuals (157 women) aged 20-66 years who farmed at least 75% of their lives. Primary bone outcomes included areal bone mineral density (aBMD), aBMD Z-scores, cortical and trabecular volumetric BMD, cortical thickness and periosteal circumference. Relationship between bone and recall of level of farm mechanization as a child was determined after stratifying by sex and controlling for covariates.RESULTS: Controlling for covariates, females from low mechanized farms had higher femoral neck (FN) bone area (p=0.03) than those on high or moderate mechanized farms. No group differences in pQCT ulna measurements or z-scores were found in either gender.CONCLUSION: A low farm mechanization level (high physical activity) prior to 20 years of age is associated with greater FN bone area in females. Future research that includes type and amount of physical activity performed will contribute to growing knowledge of how and when regular physical activity during childhood and adolescence affects adult bone health

    Leading Order Calculation of Shear Viscosity in Hot Quantum Electrodynamics from Diagrammatic Methods

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    We compute the shear viscosity at leading order in hot Quantum Electrodynamics. Starting from the Kubo relation for shear viscosity, we use diagrammatic methods to write down the appropriate integral equations for bosonic and fermionic effective vertices. We also show how Ward identities can be used to put constraints on these integral equations. One of our main results is an equation relating the kernels of the integral equations with functional derivatives of the full self-energy; it is similar to what is obtained with two-particle-irreducible effective action methods. However, since we use Ward identities as our starting point, gauge invariance is preserved. Using these constraints obtained from Ward identities and also power counting arguments, we select the necessary diagrams that must be resummed at leading order. This includes all non-collinear (corresponding to 2 to 2 scatterings) and collinear (corresponding to 1+N to 2+N collinear scatterings) rungs responsible for the Landau-Pomeranchuk-Migdal effect. We also show the equivalence between our integral equations obtained from quantum field theory and the linearized Boltzmann equations of Arnold, Moore and Yaffe obtained using effective kinetic theory.Comment: 45 pages, 22 figures (note that figures 7 and 14 are downgraded in resolution to keep this submission under 1000kb, zoom to see them correctly

    Utilizing RADseq data for phylogenetic analysis of challenging taxonomic groups: A case study in Carex sect. Racemosae

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141466/1/ajb20337-sup-0001.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141466/2/ajb20337.pd

    Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ.

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    We previously identified FOXL2 as a critical component in FSHβ gene transcription. Here, we show that mice deficient in FOXL2 have lower levels of gonadotropin gene expression and fewer LH- and FSH-containing cells, but the same level of other pituitary hormones compared to wild-type littermates, highlighting a role of FOXL2 in the pituitary gonadotrope. Further, we investigate the function of FOXL2 in the gonadotrope cell and determine which domains of the FOXL2 protein are necessary for induction of FSHβ transcription. There is a stronger induction of FSHβ reporter transcription by truncated FOXL2 proteins, but no induction with the mutant lacking the forkhead domain. Specifically, FOXL2 plays a role in activin induction of FSHβ, functioning in concert with activin-induced SMAD proteins. Activin acts through multiple promoter elements to induce FSHβ expression, some of which bind FOXL2. Each of these FOXL2-binding sites is either juxtaposed or overlapping with a SMAD-binding element. We determined that FOXL2 and SMAD4 proteins form a higher order complex on the most proximal FOXL2 site. Surprisingly, two other sites important for activin induction bind neither SMADs nor FOXL2, suggesting additional factors at work. Furthermore, we show that FOXL2 plays a role in synergistic induction of FSHβ by GnRH and activin through interactions with the cJUN component of the AP1 complex that is necessary for GnRH responsiveness. Collectively, our results demonstrate the necessity of FOXL2 for proper FSH production in mice and implicate FOXL2 in integration of transcription factors at the level of the FSHβ promoter

    Environmental Effects on Real-Space and Redshift-Space Galaxy Clustering

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    Galaxy formation inside dark matter halos, as well as the halo formation itself, can be affected by large-scale environments. Evaluating the imprints of environmental effects on galaxy clustering is crucial for precise cosmological constraints with data from galaxy redshift surveys. We investigate such an environmental impact on both real-space and redshift-space galaxy clustering statistics using a semi-analytic model derived from the Millennium Simulation. We compare clustering statistics from original SAM galaxy samples and shuffled ones with environmental influence on galaxy properties eliminated. Among the luminosity-threshold samples examined, the one with the lowest threshold luminosity (~0.2L_*) is affected by environmental effects the most, which has a ~10% decrease in the real-space two-point correlation function (2PCF) after shuffling. By decomposing the 2PCF into five different components based on the source of pairs, we show that the change in the 2PCF can be explained by the age and richness dependence of halo clustering. The 2PCFs in redshift space are found to change in a similar manner after shuffling. If the environmental effects are neglected, halo occupation distribution modeling of the real-space and redshift-space clustering may have a less than 6.5% systematic uncertainty in constraining beta from the most affected SAM sample and have substantially smaller uncertainties from the other, more luminous samples. We argue that the effect could be even smaller in reality. In the Appendix, we present a method to decompose the 2PCF, which can be applied to measure the two-point auto-correlation functions of galaxy sub-samples in a volume-limited galaxy sample and their two-point cross-correlation functions in a single run utilizing only one random catalog.Comment: 13 pages, 6 figures, Accepted by AP
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