MEASUREMENT OF THE REGRESSION RATE IN A HYBRID ROCKET MOTOR BY ACQUIRING THE HELMHOLTZ FREQUENCY IN THE COMBUSTION CHAMBER

Low thrust values obtained with a hybrid rocket motor (HRM) are a consequence of the difficulty in quickly mixing the fuel and oxidizer, which is characterized by a low regression rate of the fuel grain. Therefore, the measurement of this parameter is of great importance in studies that aim at solutions for this deficiency in HRM. Several studies calculate a reliable value of the average regression rate over time by measuring the total mass of fuel before and after each burn. A method to measure instantaneous regression rate is by acquiring the Helmholtz resonance frequency in the combustion chamber. This work uses a piezoelectric pressure transducer to obtain the Helmholtz frequency mode of the combustion chamber in a laboratory scale test bench with high-density polyethylene (HDPE) and gaseous oxygen, and is based on the principle that this frequency is inversely proportional to the square-root of the chamber volume. With the chamber volume variation, the port diameter of the grain variation is obtained. In conclusion, the calculated variation of port diameter agreed well with the correlation for average regression rate, determined from mass loss during operation

Ensemble of Hankel Matrices for Face Emotion Recognition

In this paper, a face emotion is considered as the result of the composition of multiple concurrent signals, each corresponding to the movements of a specific facial muscle. These concurrent signals are represented by means of a set of multi-scale appearance features that might be correlated with one or more concurrent signals. The extraction of these appearance features from a sequence of face images yields to a set of time series. This paper proposes to use the dynamics regulating each appearance feature time series to recognize among different face emotions. To this purpose, an ensemble of Hankel matrices corresponding to the extracted time series is used for emotion classification within a framework that combines nearest neighbor and a majority vote schema. Experimental results on a public available dataset shows that the adopted representation is promising and yields state-of-the-art accuracy in emotion classification.Comment: Paper to appear in Proc. of ICIAP 2015. arXiv admin note: text overlap with arXiv:1506.0500

On the use of AMSU-based products for the description of soil water content at basin scale

Abstract. Characterizing the dynamics of soil moisture fields is a key issue in hydrology, offering a strategy to improve our understanding of complex climate-soil-vegetation interactions. Besides in-situ measurements and hydrological models, soil moisture dynamics can be inferred by analyzing data acquired by sensors on board of airborne and/or satellite platforms. In this work, we investigated the use of the National Oceanic and Atmospheric Administration – Advanced Microwave Sounding Unit-A (NOAA-AMSU-A) radiometer for the remote characterization of soil water content. To this aim, a field measurement campaign, lasted about three months (3 March 2010–18 May 2010), was carried out using a portable time-domain reflectometer (TDR) to get soil water content measures over five different locations within an experimental basin of 32.5 km2, located in the South of Italy. In detail, soil moisture measurements were carried out systematically at the times of satellite overpasses, over two square areas of 400 m2, a triangular area of 200 m2 and two transects of 60 and 170 m, respectively. Each monitored site is characterized by different land covers and soil textures, to account for spatial heterogeneity of land surface. Afterwards, a more extensive comparison (i.e. analyzing a 5 yr data time series) was made using soil moisture simulated by a hydrological model. Measured and modeled soil moisture data were compared with two AMSU-based indices: the Surface Wetness Index (SWI) and the Soil Wetness Variation Index (SWVI). Both time series of indices have been filtered by means of an exponential filter to account for the fact that microwave sensors only provide information at the skin surface. This allowed to understand the ability of each satellite-based index to account for soil moisture dynamics and to understand its performances under different conditions. As a general remark, the comparison shows a higher ability of the filtered SWI to describe the general trend of soil moisture, while the SWVI can capture soil moisture variations with a precision that increases at the higher values of SWVI

Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer

The clinical relevance of bax and bcl-2 protein expression has been investigated in 84 patients with recurrent or metastatic colorectal cancer submitted to a chemotherapy regimen including methotrexate and fluorouracil/leucovorin. Cytoplasmic immunostaining of bax and bcl-2 was present in 65.5% and 38%, respectively, of the tumours. No association was found between bax and bcl-2 or between p53 and bax or bcl-2 protein expression. Moreover, the biomarkers were unrelated to patient and tumour characteristics known to affect the clinical outcome of colorectal cancer patients. In general, the apoptosis-related markers did not appear indicative of short- and long-term clinical response nor of prognosis. Bcl-2-negative lesions were more frequent among patients who reached an objective clinical response, which is in agreement with previously reported data regarding other tumour types. When the interrelationship between p53 and bax expression was examined, a better response rate (40%) was found for patients whose tumours did not express p53 and bax, and a better prognosis (2-year probability of overall survival 75%) for patients with p53-positive and bax-negative tumours. In the present series of patients with advanced colorectal cancer submitted to systemic chemotherapy we did not find a clear association between expression of apoptosis-related markers and clinical outcome, even in the subset of patients in which the apoptotic index as determined by the TUNEL approach was investigated. © 2001 Cancer Research Campaign http://www.bjcancer.co

NREL Gearbox Reliability Collaborative: Comparing In-Field Gearbox Response to Different Dynamometer Test Conditions: Preprint

This paper presents the results of NREL's Gearbox Reliability Collaborative comparison of dynamometer tests conducted on a 750-kW gearbox to field testing

Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients

The purpose of this work was to analyse the ability of p53 and thymidilate synthase (TS) primary tumour expression to retrospectively predict clinical response to chemotherapy and long-term prognosis in patients with advanced colorectal cancers homogeneously treated by methotrexate (MTX)-modulated–5-fluorouracil (5-FU-FA). A total of 108 advanced colorectal cancer patients entered the present retrospective study. Immunohistochemical p53 (pAb 1801 mAb) and TS (TS106 mAb) expression on formalin-fixed paraffin-embedded primary tumour specimens was related to probability of clinical response to chemotherapy, time to progression and overall survival. p53 was expressed in 53/108 (49%) tumours, while 54/108 (50%) showed TS immunostaining. No relationship was demonstrated between p53 positivity and clinical response to chemotherapy (objective response (OR): 20% vs 23%, in p53+ and p53– cases respectively) or overall survival. Percent of OR was significantly higher in TS-negative with respect to TS-positive tumours (30% vs 15% respectively;P< 0.04); simultaneous analysis of TS and p53 indicated 7% OR for p53-positive/TS-positive tumours vs 46% for p53-positive/TS-negative tumours (P< 0.03). Logistic regression analysis confirmed a significant association between TS tumour status and clinical response to chemotherapy (hazard ratio (HR): 2.91; 95% confidence interval (CI) 8.34–1.01; two-sided P< 0.05). A multivariate analysis of overall survival showed that only a small number of metastatic sites was statistically relevant (HR 1.89; 95% CI 2.85–1.26; two-sided P< 0.03). Our study suggests that immunohistochemical expression of p53 and TS could assist the clinician in predicting response of colorectal cancer patients to modulated MTX-5-FU therapy. © 2000 Cancer Research Campaig

Discovery of underground argon with low level of radioactive 39Ar and possible applications to WIMP dark matter detectors

We report on the first measurement of 39Ar in argon from underground natural gas reservoirs. The gas stored in the US National Helium Reserve was found to contain a low level of 39Ar. The ratio of 39Ar to stable argon was found to be <=4x10-17 (84% C.L.), less than 5% the value in atmospheric argon (39Ar/Ar=8x10-16). The total quantity of argon currently stored in the National Helium Reserve is estimated at 1000 tons. 39Ar represents one of the most important backgrounds in argon detectors for WIMP dark matter searches. The findings reported demonstrate the possibility of constructing large multi-ton argon detectors with low radioactivity suitable for WIMP dark matter searches.Comment: 6 pages, 2 figures, 2 table

Evaluation of Magnetic Micro- and Nanoparticle Toxicity to Ocular Tissues

Purpose: Magnetic nanoparticles (MNPs) may be used for focal delivery of plasmids, drugs, cells, and other applications. Here we ask whether such particles are toxic to ocular structures. Methods: To evaluate the ocular toxicity of MNPs, we asked if either 50 nm or 4 mm magnetic particles affect intraocular pressure, corneal endothelial cell count, retinal morphology including both cell counts and glial activation, or photoreceptor function at different time points after injection. Sprague-Dawley rats (n = 44) were injected in the left eye with either 50 nm (3 ml, 1.65 mg) or 4 mm(3ml, 1.69 mg) magnetic particles, and an equal volume of PBS into the right eye. Electroretinograms (ERG) were used to determine if MNPs induce functional changes to the photoreceptor layers. Enucleated eyes were sectioned for histology and immunofluorescence. Results: Compared to control-injected eyes, MNPs did not alter IOP measurements. ERG amplitudes for a-waves were in the 100–250 mV range and b-waves were in the 500–600 mV range, with no significant differences between injected and noninjected eyes. Histological sectioning and immunofluorescence staining showed little difference in MNP-injected animals compared to control eyes. In contrast, at 1 week, corneal endothelial cell numbers were significantly lower in the 4 mm magnetic particle-injected eyes compared to either 50 nm MNP- or PBS-injected eyes. Furthermore, iron deposition was detected after 4 mm magnetic particle but not 50 nm MNP injection