Analyzing the Potential Moderating Effect of School SES on the Relationship Between Student Sexuality and Mental Health

Background: It is estimated 1 in 5 children in the United States of America have a diagnosable mental health disorder, with only 21% of these children receiving treatment (American Academy of Pediatrics, 2017). Lesbian, gay, bisexual, and transgender (LBGT) youth mental health issues have been a consistent area of concern (Gonsiorek, 1988). The presence or absence of health-related resources and programs in schools has been shown to alter the health outcomes of students in their care (Leger, 1999). However, the extent to which a school can implement programs depends largely on a school’s socioeconomic status (SES). This study uses publicly accessible data from several sources to evaluate the moderating effect of school SES on the relationship between sexual orientation and mental health among primary and secondary students. Methods: Surveys were collected from 15,624 students in grades 9-12 through the National Youth Risk Behavior Survey (YRBS) (CDC, 2015). Data related to student sexuality and their mental health was extracted from this dataset. Students surveyed were also divided into 18 distinct large urban school districts and this was used to find the funding per student for each student surveyed in each district. A three variable cross tabulation analysis was conducted to assess the role of SES on the relationship between sexual orientation and mental health among the students surveyed. Discussion and Conclusion: The results of this analysis indicate that school socioeconomic status does not have a large moderating effect in the relationship between student sexuality and mental health. This finding is of particular interest because it suggests that school SES does not impact LGBT students’ mental health any more than their relatively mentally healthier peers. It may be worthwhile for schools with more funding available per student to direct efforts to specifically benefit groups who are disproportionately affected by mental health disorders, such as LGBT students

Dependence of Crystallite Formation and Preferential Backbone Orientations on the Side Chain Pattern in PBDTTPD Polymers

Alkyl substituents appended to the π-conjugated main chain account for the solution-processability and film-forming properties of most π-conjugated polymers for organic electronic device applications, including field-effect transistors (FETs) and bulk-heterojunction (BHJ) solar cells. Beyond film-forming properties, recent work has emphasized the determining role that side-chain substituents play on polymer self-assembly and thin-film nanostructural order, and, in turn, on device performance. However, the factors that determine polymer crystallite orientation in thin-films, implying preferential backbone orientation relative to the device substrate, are a matter of some debate, and these structural changes remain difficult to anticipate. In this report, we show how systematic changes in the side-chain pattern of poly(benzo[1,2-b:4,5-b′]dithiophene–alt–thieno[3,4-c]pyrrole-4,6-dione) (PBDTTPD) polymers can (i) influence the propensity of the polymer to order in the π-stacking direction, and (ii) direct the preferential orientation of the polymer crystallites in thin films (e.g., “face-on” vs “edge-on”). Oriented crystallites, specifically crystallites that are well-ordered in the π-stacking direction, are believed to be a key contributor to improved thin-film device performance in both FETs and BHJ solar cells

Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B.

Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs. In contrast with Notch, we show that the transcription factor CSL (also known as RBP-Jκ), a key effector of canonical Notch signaling endowed with intrinsic transcription-repressive functions, plays a tumor-promoting function in SCC development. Expression of this gene decreased in upper epidermal layers and human keratinocytes (HKCs) undergoing differentiation, while it increased in premalignant and malignant SCC lesions from skin, head/neck, and lung. Increased CSL levels enhanced the proliferative potential of HKCs and SCC cells, while silencing of CSL induced growth arrest and apoptosis. In vivo, SCC cells with increased CSL levels gave rise to rapidly expanding tumors, while cells with silenced CSL formed smaller and more differentiated tumors with enhanced inflammatory infiltrate. Global transcriptomic analysis of HKCs and SCC cells with silenced CSL revealed major modulation of apoptotic, cell-cycle, and proinflammatory genes. We also show that the histone demethylase KDM6B is a direct CSL-negative target, with inverse roles of CSL in HKC and SCC proliferative capacity, tumorigenesis, and tumor-associated inflammatory reaction. CSL/KDM6B protein expression could be used as a biomarker of SCC development and indicator of cancer treatment

Electron-Deficient N-Alkyloyl Derivatives of Thienopyrrole-4,6-dione Yield Efficient Polymer Solar Cells with Open-Circuit Voltages > 1 V

Poly(benzo[1,2-b:4,5-b′]dithiophene–thieno[3,4-c]pyrrole-4,6-dione) (PBDTTPD) polymer donors yield some of the highest open-circuit voltages (VOC, ca. 0.9 V) and fill factors (FF, ca. 70%) in conventional bulk-heterojunction (BHJ) solar cells with PCBM acceptors. Recent work has shown that the incorporation of ring substituents into the side chains of the BDT motifs in PBDTTPD can induce subtle variations in material properties, resulting in an increase of the BHJ device VOC to ∼1 V. In this contribution, we report on the synthesis of N-alkyloyl-substituted TPD motifs (TPD(CO)) and show that the electron-deficient motifs can further lower both the polymer LUMO and HOMO levels, yielding device VOC > 1 V (up to ca. 1.1 V) in BHJ solar cells with PCBM. Despite the high VOC achieved (i.e., low polymer HOMO), BHJ devices cast from TPD(CO)-based polymer donors can reach power conversion efficiencies (PCEs) of up to 6.7%, making these promising systems for use in the high-band-gap cell of tandem solar cells

Ring Substituents Mediate the Morphology of PBDTTPD-PCBM Bulk-Heterojunction Solar Cells

Among π-conjugated polymer donors for efficient bulk-heterojunction (BHJ) solar cell applications, poly(benzo[1,2-b:4,5-b′]dithiophene–thieno[3,4-c]pyrrole-4,6-dione) (PBDTTPD) polymers yield some of the highest open-circuit voltages (VOC, ca. 0.9 V) and fill-factors (FF, ca. 70%) in conventional (single-cell) BHJ devices with PCBM acceptors. In PBDTTPD, side chains of varying size and branching affect polymer self-assembly, nanostructural order, and impact material performance. However, the role of the polymer side-chain pattern in the intimate mixing between polymer donors and PCBM acceptors, and on the development of the BHJ morphology is in general less understood. In this contribution, we show that ring substituents such as furan (F), thiophene (T) and selenophene (S)—incorporated into the side chains of PBDTTPD polymers—can induce significant and, of importance, very different morphological effects in BHJs with PCBM. A combination of experimental and theoretical (via density functional theory) characterizations sheds light on how varying the heteroatom of the ring substituents impacts (i) the preferred side-chain configurations and (ii) the ionization, electronic, and optical properties of the PBDTTPD polymers. In parallel, we find that the PBDT(X)TPD analogs (with X = F, T, or S) span a broad range of power conversion efficiencies (PCEs, 3–6.5%) in optimized devices with improved thin-film morphologies via the use of 1,8-diiodooctane (DIO), and discuss that persistent morphological impediments at the nanoscale can be at the origin of the spread in PCE across optimized PBDT(X)TPD-based devices. With their high VOC ∼1 V, PBDT(X)TPD polymers are promising candidates for use in the high-band gap cell of tandem solar cells

Next-generation HVAC: Prospects for and limitations of desiccant and membrane-based dehumidification and cooling

Recently, next-generation HVAC technologies have gained attention as potential alternatives to the conventional vapor-compression system (VCS) for dehumidification and cooling. Previous studies have primarily focused on analyzing a specific technology or its application to a particular climate. A comparison of these technologies is necessary to elucidate the reasons and conditions under which one technology might outperform the rest. In this study, we apply a uniform framework based on fundamental thermodynamic principles to assess and compare different HVAC technologies from an energy conversion standpoint. The thermodynamic least work of dehumidification and cooling is formally defined as a thermodynamic benchmark, while VCS performance is chosen as the industry benchmark against which other technologies, namely desiccant-based cooling system (DCS) and membrane-based cooling system (MCS), are compared. The effect of outdoor temperature and humidity on device performance is investigated, and key insights underlying the dehumidification and cooling process are elucidated. In spite of the great potential of DCS and MCS technologies, our results underscore the need for improved system-level design and integration if DCS or MCS are to compete with VCS. Our findings have significant implications for the design and operation of next-generation HVAC technologies and shed light on potential avenues to achieve higher efficiencies in dehumidification and cooling applications

Copyright: a roadblock to education in developing countries?

Copyright protection is intended to promote creativity by granting the creator of an original work, exclusive rights to its use for a limited time period. However, there has been a growing debate about whether copyright laws and their strict implementation, particularly in developing countries, could be detrimental to efforts by these countries to promote access to knowledge in general, and to educational material in particular. This debate, though not entirely new, is taking place in the context of intense policy discussions since the late 1990s about the impact of global intellectual property rules, such as those of the WTO TRIPS Agreement, on developing countries and about the extent to which such rules are supportive of public policy objectives in areas crucial to achieving sustainable development such as health, education and the environment. This paper examines the relationship between copyright protection and access to educational material. In this context, it looks, in particular, at the role of limitations and exceptions to copyright which in principle seek to reconcile both the interest of rights holders and public interest but whose implementation in practice has proved challenging in a number developing of countries. The paper seeks to identify options that will enable developing countries to formulate national copyright regimes that give priority to access to knowledge in the form of educational material

Improving the long-term stability of PBDTTPD polymer solar cells through material purification aimed at removing organic impurities

While bulk heterojunction (BHJ) solar cells fabricated from high Mn PBDTTPD achieve power conversion efficiencies (PCE) as high as 7.3%, the short-circuit current density (JSC) of these devices can drop by 20% after seven days of storage in the dark and under inert conditions. This degradation is characterized by the appearance of S-shape features in the reverse bias region of current–voltage (J–V) curves that increase in amplitude over time. Conversely, BHJ solar cells fabricated from low Mn PBDTTPD do not develop S-shaped J–V curves. However, S-shapes identical to those observed in high Mn PBDTTPD solar cells can be induced in low Mn devices through intentional contamination with the TPD monomer. Furthermore, when high Mn PBDTTPD is purified via size exclusion chromatography (SEC) to reduce the content of low molecular weight species, the JSC of polymer devices is significantly more stable over time. After 111 days of storage in the dark under inert conditions, the J–V curves do not develop S-shapes and the JSC degrades by only 6%. The S-shape degradation feature, symptomatic of low device lifetimes, appears to be linked to the presence of low molecular weight contaminants, which may be trapped within samples of high Mn polymer that have not been purified by SEC. Although these impurities do not affect initial device PCE, they significantly reduce device lifetime, and solar cell stability is improved by increasing the purity of the polymer materials

Photoperiod regulates the daily profiles of Tryptophan Hydroxylase-2 gene expression the raphe nuclei of rats

Tryptophan hydroxylase-2 mRNA (TPH, the rate limiting enzyme in 5-HT synthesis) expression levels display circadian variations in the median and dorsal raphe nuclei. This circadian pattern is under the control of the suprachiasmatic nuclei (SCN), the master clock. Photoperiodic cue is encoded by the SCN which convey the seasonal message to target sites. In the present study, we have investigated the effect of photoperiodic changes on the serotonergic neurones of the raphe nuclei. We have assessed the daily expression of TPH2 mRNA in both median and dorsal raphe nuclei of rats housed either under long photoperiod (18 h light/6 h dark cycle, LP18:6) or short photoperiod (SP6:18). Our results demonstrate that under LP18:6, TPH2 mRNA levels display a progressive decrease during the dark period and a maximal expression is reported at the beginning of the light period. The expression pattern of TPH2 mRNA under SP6:18 remains unchanged during the dark period and increases significantly before the day/night transition. This latter expression pattern is in line with the daily profiles of TPH2 mRNA reported previously under standard lighting regimen (12 h light/12 h dark cycle). The present results suggest that TPH2 mRNA expression pattern within DR and MR is affected by photoperiod which might in turn affect TPH content and 5­HT release within the circadian structures, but also in all the serotonergic projection areas of the brain