The geography of taste: analyzing cell-phone mobility and social events

This paper deals with the analysis of crowd mobility during special events. We analyze nearly 1 million cell-phone traces and associate their destinations with social events. We show that the origins of people attending an event are strongly correlated to the type of event, with implications in city management, since the knowledge of additive flows can be a critical information on which to take decisions about events management and congestion mitigation

A randomized, controlled trial of initial anti-retroviral therapy with abacavir/lamivudine/zidovudine twice-daily compared to atazanavir once-daily with lamivudine/zidovudine twice-daily in HIV-infected patients over 48 weeks (ESS100327, the ACTION Study)

<p>Abstract</p> <p>Background</p> <p>Traditional first line regimens containing a non-nucleoside reverse transcriptase inhibitor or protease inhibitor may not be suitable for a subset of antiretroviral-naïve patients such as those with certain co-morbidities, women of child-bearing potential, and intolerability to components of standard first line therapy. This study was conducted to determine if alternate treatment options may meet the needs of both general and special patient populations. The ACTION study was a randomized, open-label, multicenter, 48-week trial that compared the safety and efficacy of a triple nucleoside regimen versus a protease inhibitor plus a dual nucleoside regimen in HIV-1 treatment-naïve subjects.</p> <p>Results</p> <p>279 HIV-infected subjects with HIV-1 RNA (VL) >5000 but < 200,000 copies/mL (c/mL) and CD4+ count ≥ 100 cells/mm³were randomized (1:1) to receive abacavir sulfate/lamivudine/zidovudine (ABC/3TC/ZDV) twice-daily or atazanavir (ATV) once-daily plus lamivudine/zidovudine (3TC/ZDV) twice-daily. Protocol-defined virologic failure was based on multiple failure criteria.</p> <p>Non-inferiority of ABC/3TC/ZDV to ATV+3TC/ZDV was established with 62% vs. 59% of subjects achieving a VL < 50 c/mL at week 48, [ITT(E), M/S = F, 95% CI: -5.9, 10.4]. Similar results were observed in the 230 (82%) subjects with baseline VL<100,000 c/mL (ABC/3TC/ZDV vs. ATV+3TC/ZDV), 66% vs. 59%; 95% CI: -5.6, 19.5. However, ABC/3TC/ZDV did not meet the non-inferiority criterion compared to ATV+3TC/ZDV in the 48 subjects with baseline VL ≥ 100,000 c/mL, 39% vs. 60%; 95% CI: -49.2, 7.4, respectively. Protocol-defined virologic failure was similar between groups.</p> <p>Conclusion</p> <p>ABC/3TC/ZDV demonstrated comparable virologic efficacy to ATV+3TC/ZDV in this population over 48 weeks. In those with a baseline VL ≥ 100,000 c/mL, subjects in the ATV+3TC/ZDV showed better virologic efficacy. Both regimens offer benefits in select therapy-naïve subjects.</p> <p>Trial Registration</p> <p>[Clinical Trials Identifier, NCT00082394].</p

Development of brown rot epidemics in Spanish peach orchards

A new approach to modelling epidemics of brown rot caused by Monilinia spp. in Ebro Valley peach orchards has been developed. This compartmental model was subdivided according to the phenological stages in which the disease can develop (blossom, immature fruit, and ripe fruit). Information host susceptibility, primary and secondary inoculum sources and latent infections in immature fruit was taken into account. The compartmental model is described by a system of differential equations, and is simple enough to allow an analytical study of the main epidemiological factors that determine the rate of disease progress during a single growing season. The proposed model fits well to the epidemic pattern of brown rot observed in north-eastern Spain. The transmission of the disease as a non-linear term implied that small changes in the infection rate had a large effect on the development of the disease. The model has confirmed the usefulness of removing mummies (infected fruit that remains in the crop during winter) from the field to reduce the final incidence of the disease. In addition, all control measures that reduce the rate of secondary infection in ripe fruit, either through the use of more resistant varieties or the use of fungicides, are effective in reducing brown rot incidence. The proposed epidemic model is flexible and allows to add complexities to the system and evaluate the effectiveness of different control strategies.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was supported by grant PID2020-115702RB-C21 and AGL2017-84389-C2-2-R from the Ministry of Science and Innovation (Spain)

Onasemnogene abeparvovec preserves bulbar function in infants with presymptomatic spinal muscular atrophy: a post-hoc analysis of the SPR1NT trial

Bulbar function in spinal muscular atrophy has been defined as the ability to meet nutritional needs by mouth while maintaining airway protection and communicate verbally. The effects of disease-modifying treatment on bulbar function are not clear. A multidisciplinary team conducted post-hoc analyses of phase 3 SPR1NT trial data to evaluate bulbar function of infants at risk for spinal muscular atrophy who received one-time gene replacement therapy (onasemnogene abeparvovec) before symptom onset. Three endpoints represented adequate bulbar function in SPR1NT: (1) absence of physiologic swallowing impairment, (2) full oral nutrition, and (3) absence of adverse events indicating pulmonary instability. Communication was not assessed in SPR1NT. We descriptively assessed numbers/percentages of children who achieved each endpoint and all three collectively. SPR1NT included infants <6 postnatal weeks with two (n = 14) or three (n = 15) copies of the survival motor neuron 2 gene. At study end (18 [two-copy cohort] or 24 [three-copy cohort] months of age), 100% (29/29) of patients swallowed normally, achieved full oral nutrition, maintained pulmonary stability, and achieved the composite endpoint. When administered to infants before clinical symptom onset, onasemnogene abeparvovec allowed children at risk for spinal muscular atrophy to achieve milestones within published normal ranges of development and preserve bulbar function

Experiencia Inicial en Cardiodesfibrilación Empleando Electrodos de Superficie Fractal

Se presentan los resultados dei implante de una serie de cardiodesfibriladores en 27 pacientes, empleándose en todos los casos, electrodos de superfície fractal, con el objeto de obtener mayor biocompatibilidad, mejores umbrales de estimulación y sensado ventricular, y requerimientos de menor energia para la desfibrilación. El grupo estaba constituído por 8 mujeres y 21 hombres; en el 63% de los casos el generador fue implantado en el abdomen, y en el 37% restante en la zona infraclavicular. El umbral de desfibrilación verdadero (true DFT), fue obtenido em 14 pacientes (promedio 12.85 Joules, SD(n-1) + 3.89, SEM + 1.04). En el resto del grupo (13 pacientes), el menor nivel de energia exitoso (lowest energy succesfully tested) fue establecido en 16.57 Joules, SD (N-1) + 2.53, SEM + 0.677). Pudo determinarse entonces que para todo el grupo estudiado, el umbral requerido fue menor a 20 Joules en el 96.3% de los casos (26 pacientes), siendo necesaria una energía superior a 20 Joules en un único caso (3.7%). Conclusión: los electrodos de superficie fractal constituyen un interesante aporte, para obtener la reversión de la fibrilación ventricular empleando bajos niveles de energía, en pacientes sometidos ai implante de cardiodesfibriladores

Experiencia Inicial en Cardiodesfibrilación Empleando Electrodos de Superficie Fractal

Se presentan los resultados dei implante de una serie de cardiodesfibriladores en 27 pacientes, empleándose en todos los casos, electrodos de superfície fractal, con el objeto de obtener mayor biocompatibilidad, mejores umbrales de estimulación y sensado ventricular, y requerimientos de menor energia para la desfibrilación. El grupo estaba constituído por 8 mujeres y 21 hombres; en el 63% de los casos el generador fue implantado en el abdomen, y en el 37% restante en la zona infraclavicular. El umbral de desfibrilación verdadero (true DFT), fue obtenido em 14 pacientes (promedio 12.85 Joules, SD(n-1) + 3.89, SEM + 1.04). En el resto del grupo (13 pacientes), el menor nivel de energia exitoso (lowest energy succesfully tested) fue establecido en 16.57 Joules, SD (N-1) + 2.53, SEM + 0.677). Pudo determinarse entonces que para todo el grupo estudiado, el umbral requerido fue menor a 20 Joules en el 96.3% de los casos (26 pacientes), siendo necesaria una energía superior a 20 Joules en un único caso (3.7%). Conclusión: los electrodos de superficie fractal constituyen un interesante aporte, para obtener la reversión de la fibrilación ventricular empleando bajos niveles de energía, en pacientes sometidos ai implante de cardiodesfibriladores

Regulatory T cells ameliorate intrauterine growth retardation in a transgenic rat model for preeclampsia

Preeclampsia is a multisystemic syndrome during pregnancy that is often associated with intrauterine growth retardation. Immunologic dysregulation, involving T cells, is implicated in the pathogenesis. The aim of this study was to evaluate the effect of upregulating regulatory T cells in an established transgenic rat model for preeclampsia. Application of superagonistic monoclonal antibody for CD28 has been shown to effectively upregulate regulatory T cells. In the first protocol (treatment protocol), we applied 1 mg of CD28 superagonist or control antibody on days 11 and 15 of pregnancy. In the second protocol (prevention protocol), the superagonist or control antibody was applied on days 1, 5, and 9. Superagonist increased regulatory T cells in circulation and placenta from 8.49+/-2.09% of CD4-positive T cells to 23.50+/-3.05% and from 3.85+/-1.45% to 23.27+/-7.64%, respectively. Blood pressure and albuminuria (30.6+/-15.1 versus 14.6+/-5.5 mg/d) were similar in the superagonist or control antibody-treated preeclamptic group for both protocols. Rats treated with CD28 superagonist showed increased pup weights in the prevention protocol (2.66+/-0.03 versus 2.37+/-0.05 g) and in the treatment protocol (3.04+/-0.04 versus 2.54+/-0.1 g). Intrauterine growth retardation, calculated by brain:liver weight ratio, was also decreased by the superagonist in both protocols. Further analysis of brain development revealed a 20% increase in brain volume by the superagonist. Induction of regulatory T cells in the circulation and the uteroplacental unit in an established preeclamptic rat model had no influence on maternal hypertension and proteinuria. However, it substantially improved fetal outcome by ameliorating intrauterine growth retardation

Age and growth of the smooth hammerhead shark, Sphyrna zygaena, in the Eastern Equatorial Atlantic Ocean, using vertebral sections

The smooth hammerhead shark Sphyrna zygaena (Sphyrnidae) is regularly caught as bycatch in pelagic longline fisheries, but is one of the least studied of all pelagic sharks. Recently, ICCAT (International Commission for the Conservation of Atlantic Tunas) issued recommendations underlining the need for more studies on the life history parameters of this and other pelagic shark species. To this end, the age and growth of S. zygaena were studied in the Eastern Equatorial Atlantic Ocean, in an area where growth parameters were not yet available for this species. Data from 139 specimens, caught between June and September 2009, ranging in size from 136 to 233 cm fork length (FL), were analysed. Preliminary trials were carried out to assess the most efficient growth band enhancement technique. These indicated that sectioning the vertebrae into 500 μm sections followed by staining with crystal violet produced the best results. Growth models were fitted using the traditional von Bertalanffy growth equation and a modification of this equation using a known size at birth. Growth models were compared using the Akaike information criterion (AIC). The von Bertalanffy growth equation seemed to be the most adequate model to describe growth in this species, with resulting growth parameters of L inf = 272 cm FL, k = 0.06 year for males and L inf = 285 cm FL, k = 0.07 year for females. In the first four years of life, S. zygaena grows 25 cm per year on average, but its growth slows down in later life. Future stock assessment models should incorporate these age and growth parameters for species management and conservation.info:eu-repo/semantics/publishedVersio

Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage

Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression